Dredd Death related ced-3/Nedd2-like caspase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dreddprovided by FlyBase
Official Full Name: Death related ced-3/Nedd2-like caspaseprovided by FlyBase
Primary source: FLYBASE:FBgn0020381
Locus tag: Dmel_CG7486
See related: AllianceGenome:FB:FBgn0020381
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-1BCa; CASP8_DROME; CG7486; Dcp-2; DCP-2; dcp-2/dredd; Dcp-2/Dredd; DCP-2/DREDD; Dcp2; DCP2; dDredd; Dedd; Dmel\CG7486; dredd; DREDD; Dredd/DCP-2; EG:115C2.9; Redd
Summary: Enables cysteine-type endopeptidase activator activity involved in apoptotic process and endopeptidase activity. Involved in several processes, including peripheral nervous system neuron development; regulation of defense response; and sperm individualization. Located in cytoplasm. Is expressed in several structures, including dorsal ridge; embryonic head segment; female germline cell; larval ventral nerve cord; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2A; non-Hodgkin lymphoma; and stomach cancer. Orthologous to human CASP10 (caspase 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 1B12-1B13; 1-0 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (633622..635545, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (527655..529578, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Relish/miR-275/Dredd mediated negative feedback loop is crucial to restoring immune homeostasis of Drosophila Imd pathway.
Title: The Relish/miR-275/Dredd mediated negative feedback loop is crucial to restoring immune homeostasis of Drosophila Imd pathway.
interdomain cleavage of Dredd is not required for Imd or Relish processing and is not observed during immune stimulation
Title: The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35.
The authors show that stimulation of the Drosophila pattern recognition protein PGRP-LCx induces DIAP2-dependent polyubiquitylation of the initiator caspase DREDD.
Title: Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.
Dredd is an essential component of the IMD pathway required for the full activation of IMD/dJNK in cell culture and in vivo
Title: The protein Dredd is an essential component of the c-Jun N-terminal kinase pathway in the Drosophila immune response.
interaction with kep1 and effect of kep mutants on balance of dredd isoforms
Title: Kep1 interacts genetically with dredd/caspase-8, and kep1 mutants alter the balance of dredd isoforms.
Dnr1 blocks ectopic Dredd-mediated induction of an NF-kappa B reporter.
Title: Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	TAS Traceable Author Statement more info	PubMed
enables enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antibacterial peptide biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	HMP more info	PubMed
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: death related ced-3/Nedd2-like caspase

Names: CG7486-PD; CG7486-PE; CG7486-PF; CG7486-PG; Ced-3-like/Nedd2-like protein; Dredd-PD; Dredd-PE; Dredd-PF; Dredd-PG; caspase; death caspase-2; death related ced-3/Nedd2-like protein; death-related ced-3/neural precursor cell expressed developmentally downregulated 2 (NEDD2)-like protein; drosophila caspase

NP_001284751.1

EC 3.4.22.-

NP_477249.3

EC 3.4.22.-

NP_477250.3

EC 3.4.22.-

NP_477251.3

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

633622..635545 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057903.4 → NP_477251.3 death related ced-3/Nedd2-like caspase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477251.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRY7

Conserved Domains (1) summary

smart00115
Location:252 → 486

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
NM_057901.4 → NP_477249.3 death related ced-3/Nedd2-like caspase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477249.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O02433, O76797, O76798, Q8IRY7, Q95T94, Q9UB42, Q9W5E3

Conserved Domains (1) summary

cl00042
Location:252 → 492

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_057902.4 → NP_477250.3 death related ced-3/Nedd2-like caspase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477250.3

Status: REVIEWED

UniProtKB/TrEMBL

A0A3Q7YHP9, A0A3Q7YHY1

Conserved Domains (1) summary

cl00042
Location:252 → 284

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_001297822.1 → NP_001284751.1 death related ced-3/Nedd2-like caspase, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284751.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JHT0

Conserved Domains (1) summary

cl00042
Location:198 → 438

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...