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Raf Raf oncogene [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31221, updated on 9-Dec-2024

Summary

Official Symbol
Rafprovided by FlyBase
Official Full Name
Raf oncogeneprovided by FlyBase
Primary source
FLYBASE:FBgn0003079
Locus tag
Dmel_CG2845
See related
AllianceGenome:FB:FBgn0003079
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
11-29; C110; CG2845; D-raf; D-Raf; D-RAF; D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1; Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph; l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf; l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1; Raf/phl; raf1; Raf1; rafl
Summary
Enables MAP kinase kinase kinase activity and kinase binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; epithelial cell migration; and regionalization. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study cancer; cardiomyopathy; and high grade glioma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines (multiple); carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); and central nervous system benign neoplasm (multiple). Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase); BRAF (B-Raf proto-oncogene, serine/threonine kinase); and RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Raf in Genome Data Viewer
Location:
2F5-3A1; 1-0.9 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2295466..2343870)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2189499..2237903)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vitelline membrane-like Neighboring gene long non-coding RNA:CR34052 Neighboring gene long non-coding RNA:CR33218 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 6 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding  
enables MAP kinase kinase kinase activity  
enables MAP kinase kinase kinase activity PubMed 
enables kinase binding PubMed 
enables protein binding PubMed 
enables protein kinase activity  
enables protein serine/threonine kinase activity PubMed 
Items 1 - 25 of 45
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade PubMed 
involved_in MAPK cascade  
involved_in MAPK cascade PubMed 
involved_in R7 cell fate commitment PubMed 
involved_in R7 cell fate commitment PubMed 
involved_in Ras protein signal transduction PubMed 
involved_in border follicle cell migration PubMed 
involved_in cellular response to starvation PubMed 
involved_in compound eye photoreceptor development PubMed 
involved_in dorsal appendage formation PubMed 
involved_in dorsal/ventral axis specification, ovarian follicular epithelium PubMed 
involved_in epidermal growth factor receptor signaling pathway PubMed 
involved_in epidermal growth factor receptor signaling pathway PubMed 
involved_in epithelial cell migration, open tracheal system PubMed 
involved_in fibroblast growth factor receptor signaling pathway PubMed 
involved_in fibroblast growth factor receptor signaling pathway PubMed 
involved_in gastrulation PubMed 
involved_in hemocyte differentiation PubMed 
involved_in hemocyte differentiation PubMed 
involved_in imaginal disc-derived wing morphogenesis PubMed 
involved_in imaginal disc-derived wing vein specification PubMed 
involved_in instar larval development PubMed 
involved_in lamellocyte differentiation PubMed 
involved_in metamorphosis PubMed 
involved_in negative regulation of apoptotic signaling pathway PubMed 
involved_in negative regulation of macroautophagy PubMed 
involved_in photoreceptor cell development PubMed 
involved_in photoreceptor cell differentiation PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of photoreceptor cell differentiation PubMed 
involved_in protein phosphorylation  
involved_in regulation of cellular pH PubMed 
involved_in regulation of multicellular organism growth PubMed 
involved_in sevenless signaling pathway PubMed 
involved_in sevenless signaling pathway PubMed 
involved_in signal transduction  
involved_in spermatogenesis PubMed 
involved_in terminal branching, open tracheal system PubMed 
involved_in terminal region determination PubMed 
involved_in torso signaling pathway PubMed 
involved_in torso signaling pathway PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway PubMed 
involved_in wing and notum subfield formation PubMed 
involved_in wing disc morphogenesis PubMed 
Items 1 - 25 of 45
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in plasma membrane  

General protein information

Preferred Names
Raf oncogene
Names
CG2845-PA
CG2845-PE
Raf-PA
Raf-PE
l(1)pole hole
pole hole
pole-hole
polehole
raf-like-oncogene-1
NP_001096867.3
NP_525047.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2295466..2343870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103397.3 → NP_001096867.3  Raf oncogene, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096867.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8JUV5, P11346, Q0KHW7, Q8I086, Q8I0D9, Q8ISE1, Q8ISE2, Q8ISE3, Q9NEH9, Q9W4Z3
    Conserved Domains (3) summary
    cd14062
    Location:435 → 687
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd01816
    Location:142 → 212
    RBD_RAF; Ras-binding domain (RBD) found in RAF family serine/threonine kinases
    cd20811
    Location:221 → 269
    C1_Raf; protein kinase C conserved region 1 (C1 domain) found in the Raf (Rapidly Accelerated Fibrosarcoma) kinase family
  2. NM_080308.4 → NP_525047.1  Raf oncogene, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525047.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8JUV5, P11346, Q0KHW7, Q8I086, Q8I0D9, Q8ISE1, Q8ISE2, Q8ISE3, Q9NEH9, Q9W4Z3
    Related
    FBpp0070385
    Conserved Domains (3) summary
    cd14062
    Location:435 → 687
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd01816
    Location:142 → 212
    RBD_RAF; Ras-binding domain (RBD) found in RAF family serine/threonine kinases
    cd20811
    Location:221 → 269
    C1_Raf; protein kinase C conserved region 1 (C1 domain) found in the Raf (Rapidly Accelerated Fibrosarcoma) kinase family
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