Dsor1 Downstream of raf1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dsor1provided by FlyBase
Official Full Name: Downstream of raf1provided by FlyBase
Primary source: FLYBASE:FBgn0010269
Locus tag: Dmel_CG15793
See related: AllianceGenome:FB:FBgn0010269
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15793; D-mek; D-Mek; D-MEK; D-MEK/Dsor; D-sor; D-Sor; D-SOR; D-sor-1; dMek; dMEK; Dmek; DMEK-1; Dmel\CG15793; DRODSOR1; dsor; dSor; Dsor; DSor; DSOR; dsor1; dSor1; DSor1; DSOR1; DSORT; EK1-1; MAPKK; mek; Mek; MEK; MEK/Dsor1; Mek1/2; MEK1/2; sor; Sor; SOR; sor/MEK1; Su(Raf)34B
Summary: Enables MAP kinase kinase activity and kinase binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; intracellular signal transduction; and regionalization. Located in condensed chromosome. Colocalizes with nuclear envelope. Is expressed in adult brain; adult head; adult pars intercerebralis; and organism. Used to study RASopathy and cancer. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; cardiofaciocutaneous syndrome 4; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1) and MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 8D2-8D3; 1-27 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9247342..9250037)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (9141375..9144070)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ras-Dsor1 activity is independent of upstream activation by EGFR, and instead it appears to be activated by the insulin-like growth factor receptor to promote Wg signaling.
Title: Ras-activated Dsor1 promotes Wnt signaling in Drosophila development.
the Ras/MEK/MAPK pathway regulates regional-fate specification via HSPGs during development
Title: Ras/MEK/MAPK-mediated regulation of heparin sulphate proteoglycans promotes retinal fate in the Drosophila eye-antennal disc.
RNAi-mediated inhibition of MAPK-signaling by knockdown of Ras85D, phl/D-Raf or Dsor1/MEK affects larval development, adult life span and hemolymph phosphate, suggesting that some in vivo effects involve activation of this signaling pathway by phosphate.
Title: Genetic determinants of phosphate response in Drosophila.
Gem and Brm act antagonistically to modulate the EGFR-Ras-MAPK signaling pathway, by affecting Mek levels during Drosophila development
Title: Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables MAP kinase kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	HGI more info	PubMed
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in R7 cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in R7 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic DNA replication checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G2 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sevenless signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal region determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in torso signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in torso signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with nuclear envelope	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: downstream of raf1

Names: CG15793-PA; CG15793-PB; Dsor1-PA; Dsor1-PB; MAPK kinase; Map kinase kinase; dSor1; downstream of Raf1; downstream suppressor of Raf 1; drosophila MEK; mitogen-activated protein kinase kinase

NP_001285044.1

EC 2.7.12.2

NP_511098.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

9247342..9250037

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078543.4 → NP_511098.1 downstream of raf1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511098.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24324, Q8ISE0, Q9W360

Related

FBpp0071248

Conserved Domains (2) summary

cd06615
Location:85 → 382

PKc_MEK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase

smart00220
Location:88 → 364

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_001298115.1 → NP_001285044.1 downstream of raf1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285044.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JAZ3

Conserved Domains (2) summary

cd06615
Location:82 → 379

PKc_MEK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase

smart00220
Location:85 → 361

S_TKc; Serine/Threonine protein kinases, catalytic domain