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cnk connector enhancer of ksr [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36952, updated on 9-Dec-2024

Summary

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Official Symbol
cnkprovided by FlyBase
Official Full Name
connector enhancer of ksrprovided by FlyBase
Primary source
FLYBASE:FBgn0286070
Locus tag
Dmel_CG6556
See related
AllianceGenome:FB:FBgn0286070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.129; anon-WO0257455.27; CG6556; Cnk; CNK; Dmel\CG6556; EC2-3; EK2-3; l(2)k16314; sag
Summary
Enables MAP-kinase scaffold activity; enzyme regulator activity; and protein kinase binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; open tracheal system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including apical part of cell; cell cortex; and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to several human genes including CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See cnk in Genome Data Viewer
Location:
54B7-54B7; 2-82 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17413970..17420007, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13301475..13307512, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Vajk4 Neighboring gene Proteasome alpha5 subunit Neighboring gene lethal (2) k01209 Neighboring gene uncharacterized protein Neighboring gene Methylthioadenosine phosphorylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CNKSR1 gene defect can cause syndromic autosomal recessive intellectual disability. Kazeminasab S, et al. Am J Med Genet B Neuropsychiatr Genet, 2018 Dec. PMID 30450701
  2. The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor. Fritz RD, et al. Biochem Biophys Res Commun, 2005 Dec 30. PMID 16289034
  3. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Clapéron A, et al. Oncogene, 2007 May 14. PMID 17496912
  4. Ras/MAPK signaling mediates adipose tissue control of ovarian germline survival and ovulation in Drosophila melanogaster. Bradshaw T, et al. Dev Biol, 2024 Jun. PMID 38423203
  5. ERK signaling couples nutrient status to antiviral defense in the insect gut. Xu J, et al. Proc Natl Acad Sci U S A, 2013 Sep 10. PMID 23980175, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cnk and its binding partner Ave serve a critical components for Alk signaling in Drosophila
    Title: The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila.
  2. Review highlights the implication of CNK and KSR in a novel mechanism regulating RAS-mediated RAF activation.
    Title: KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.
  3. the integration of RTK-induced RAS and Src42 signals by CNK as a two-component input is essential for RAF activation
    Title: Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables MAP-kinase scaffold activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction HGI PubMed 
involved_in positive regulation of Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sevenless signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sevenless signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sevenless signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in terminal region determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in torso signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tracheal outgrowth, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
connector enhancer of ksr
Names
CG6556-PA
CG6556-PB
cnk-PA
cnk-PB
connector enhancer of KSR
enhancer of KDN
semang

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17413970..17420007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299595.1 → NP_001286524.1  connector enhancer of ksr, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286524.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KNQ9
    Conserved Domains (6) summary
    cd09511
    Location:6 → 74
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:7 → 74
    SAM; Sterile alpha motif
    cd00992
    Location:206 → 283
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13326
    Location:720 → 810
    PH_CNK_insect-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:720 → 814
    PH; PH domain
    pfam10534
    Location:82 → 165
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

  2. NM_166223.2 → NP_725671.1  connector enhancer of ksr, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725671.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KNQ9
    Related
    FBpp0086117
    Conserved Domains (6) summary
    cd09511
    Location:6 → 74
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:7 → 74
    SAM; Sterile alpha motif
    cd00992
    Location:206 → 283
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13326
    Location:720 → 810
    PH_CNK_insect-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:720 → 814
    PH; PH domain
    pfam10534
    Location:82 → 165
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KNQ9 Q7KNQ9

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