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AspRS-m Aspartyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326155, updated on 4-Jan-2025

Summary

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Official Symbol
AspRS-mprovided by FlyBase
Official Full Name
Aspartyl-tRNA synthetase, mitochondrialprovided by FlyBase
Primary source
FLYBASE:FBgn0051739
Locus tag
Dmel_CG31739
See related
AllianceGenome:FB:FBgn0051739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17938; CG31739; Dmel\CG31739
Summary
Predicted to enable aspartate-tRNA ligase activity. Predicted to be involved in aspartyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to human DARS2 (aspartyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See AspRS-m in Genome Data Viewer
Location:
36B2-36B2; 2-53 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16827078..16832093)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16827078..16832093)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene midway Neighboring gene Chromosome segregation 1 Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 9 Neighboring gene Sarcolamban B Neighboring gene Sarcolamban A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conserved regulation of cardiac calcium uptake by peptides encoded in small open reading frames. Magny EG, et al. Science, 2013 Sep 6. PMID 23970561
  2. Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells. Wang ZA, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 19966222, Free PMC Article
  3. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
  4. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Wang ZA, et al. Nat Commun, 2012 Apr 3. PMID 22473013, Free PMC Article
  5. Pilot RNAi Screen in Drosophila Neural Stem Cell Lineages to Identify Novel Tumor Suppressor Genes Involved in Asymmetric Cell Division. Manzanero-Ortiz S, et al. Int J Mol Sci, 2021 Oct 20. PMID 34768763, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartate-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartate-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aspartyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aspartyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Aspartyl-tRNA synthetase, mitochondrial
Names
AspRS-m-PA
AspRS-m-PB
AspRS-m-PD
CG31739-PA
CG31739-PB
CG31739-PD
NP_001260519.1
NP_001260520.2
NP_724018.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16827078..16832093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165196.2 → NP_724018.1  Aspartyl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724018.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJH2, Q9VJH3
    Related
    FBpp0080475
    Conserved Domains (4) summary
    PRK00476
    Location:405 → 988
    aspS; aspartyl-tRNA synthetase; Validated
    cd00777
    Location:542 → 960
    AspRS_core; Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the ...
    cd04317
    Location:405 → 538
    EcAspRS_like_N; EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) ...
    cl09930
    Location:91 → 246
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

  2. NM_001273590.1 → NP_001260519.1  Aspartyl-tRNA synthetase, mitochondrial, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260519.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJH2, Q9VJH3
    Conserved Domains (4) summary
    PRK00476
    Location:405 → 988
    aspS; aspartyl-tRNA synthetase; Validated
    cd00777
    Location:542 → 960
    AspRS_core; Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the ...
    cd04317
    Location:405 → 538
    EcAspRS_like_N; EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) ...
    cl09930
    Location:91 → 246
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

  3. NM_001273591.1 → NP_001260520.2  Aspartyl-tRNA synthetase, mitochondrial, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDL2
    Conserved Domains (3) summary
    PRK00476
    Location:462 → 1045
    aspS; aspartyl-tRNA synthetase; Validated
    cd04317
    Location:291 → 410
    EcAspRS_like_N; N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) Helicobacter pylori ...
    cl09930
    Location:148 → 303
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDL2 M9PDL2
Q9VJH2 Q9VJH2

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