Arc1 Activity-regulated cytoskeleton associated protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Arc1provided by FlyBase
Official Full Name: Activity-regulated cytoskeleton associated protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0033926
Locus tag: Dmel_CG12505
See related: AllianceGenome:FB:FBgn0033926
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0153538.31; anon-WO0153538.40; anon-WO0153538.41; anon-WO0153538.43; anon-WO0153538.45; Arc; arc1; CG12505; darc1; dArc1; dARC1; Dmel\CG12505
Summary: Enables mRNA binding activity and structural molecule activity. Involved in several processes, including behavioral response to starvation; mRNA transport; and vesicle-mediated intercellular transport. Located in several cellular components, including postsynapse of neuromuscular junction; sarcomere; and virus-like capsid. Is expressed in several structures, including adult antennal lobe; adult brain; adult head; ganglia; and pars intercerebralis. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 50F6-50F6; 2-70 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14357927..14360297, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10245432..10247802, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tau-Induced Elevation of the Activity-Regulated Cytoskeleton Associated Protein Arc1 Causally Mediates Neurodegeneration in the Adult Drosophila Brain.
Title: Tau-Induced Elevation of the Activity-Regulated Cytoskeleton Associated Protein Arc1 Causally Mediates Neurodegeneration in the Adult Drosophila Brain.
Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.
Title: Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.
Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag.
Title: Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag.
A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.
Title: A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.
We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains
Title: Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.
Arc1 protein forms capsid-like structures that bind darc1 mRNA in neurons and is loaded into extracellular vesicles that are transferred from motorneurons to muscles.
Title: Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons.
trr and G9a also have common direct targets, including the Drosophila ortholog of Arc (Arc1), a key regulator of synaptic plasticity. Our data highlight the clinical and molecular convergence between the KMT2 and EHMT protein families, which may contribute to a molecular network underlying a larger group of intellectual disability / autism spectrum disorder -related disorders.
Title: Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder.
E347 neurons induce Arc1 in specific neighboring cells to prevent excess fat accumulation.
Title: Coordination between Drosophila Arc1 and a specific population of brain neurons regulates organismal fat.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transport	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle system process	IEP Inferred from Expression Pattern more info	PubMed
involved_in muscle system process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuronal synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated intercellular transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse of neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in virus-like capsid	IDA Inferred from Direct Assay more info	PubMed