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Apl Apollo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 59216, updated on 4-Jan-2025

Summary

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Official Symbol
Aplprovided by FlyBase
Official Full Name
Apolloprovided by FlyBase
Primary source
FLYBASE:FBgn0042178
Locus tag
Dmel_CG32165
See related
AllianceGenome:FB:FBgn0042178
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-73Bb; CG18218; CG18861; CG32165; Dmel\CG32165; Imp4/5
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in organism and testis. Orthologous to human IPO4 (importin 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See Apl in Genome Data Viewer
Location:
73A11-73B1; 3-44 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16595181..16600459)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16588281..16593559)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene lethal (3) 73Ah Neighboring gene transformer Neighboring gene spindle defective 2 Neighboring gene pseudo Neighboring gene Artemis Neighboring gene uncharacterized protein Neighboring gene Proteasome beta6 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sexual conflict drive in the rapid evolution of new gametogenesis genes. VanKuren NW, et al. Semin Cell Dev Biol, 2024 Jun-Jul. PMID 38309142
  2. Gene duplicates resolving sexual conflict rapidly evolved essential gametogenesis functions. VanKuren NW, et al. Nat Ecol Evol, 2018 Apr. PMID 29459709, Free PMC Article
  3. APOLLO, a testis-specific Drosophila ortholog of importin-4, mediates the loading of protamine-like protein Mst77F into sperm chromatin. Emelyanov AV, et al. J Biol Chem, 2023 Oct. PMID 37660905, Free PMC Article
  4. Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects. Mirsalehi A, et al. BMC Genomics, 2021 Dec 5. PMID 34863092, Free PMC Article
  5. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. Xia S, et al. PLoS Genet, 2021 Jul. PMID 34242211, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
apollo
Names
Apl-PA
Apl-PB
Apl-PC
CG32165-PA
CG32165-PB
CG32165-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16595181..16600459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300155.1 → NP_001287084.1  apollo, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287084.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFW8, Q8SWQ9
    Conserved Domains (2) summary
    smart00913
    Location:29 → 90
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:335 → 363
    HEAT; HEAT repeat [structural motif]

  2. NM_168676.2 → NP_730182.1  apollo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730182.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SWQ9, Q9I7R5
    Related
    FBpp0075072
    Conserved Domains (2) summary
    smart00913
    Location:29 → 90
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:356 → 384
    HEAT; HEAT repeat [structural motif]

  3. NM_001275027.1 → NP_001261956.1  apollo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261956.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFW8, Q8SWQ9
    Conserved Domains (2) summary
    smart00913
    Location:29 → 90
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:335 → 363
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFW8 M9PFW8
Q9I7R5 Q9I7R5

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