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Aldh Aldehyde dehydrogenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34256, updated on 9-Dec-2024

Summary

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Official Symbol
Aldhprovided by FlyBase
Official Full Name
Aldehyde dehydrogenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0012036
Locus tag
Dmel_CG3752
See related
AllianceGenome:FB:FBgn0012036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
146084_at; ACDH; ALDH; ALDHA1; CG 3752; CG3752; DmALDH; Dmel\CG3752; FBgn0012036; Q9VLC5; TMABADH
Summary
Enables acetaldehyde dehydrogenase (acetylating) activity and aldehyde dehydrogenase (NAD+) activity. Involved in acetaldehyde metabolic process and response to ethanol. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; anterior endoderm; endoderm anlage; and gut section. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Aldh in Genome Data Viewer
Location:
30B1-30B1; 2-35 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9387389..9391567)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9387389..9391567)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43865 Neighboring gene uncharacterized protein Neighboring gene Shaw-like Neighboring gene uncharacterized protein Neighboring gene Multicopper oxidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Parallel functional changes in independent testis-specific duplicates of Aldehyde dehydrogenase in Drosophila. Chakraborty M, et al. Mol Biol Evol, 2015 Apr. PMID 25564519, Free PMC Article
  2. A worldwide polymorphism in aldehyde dehydrogenase in Drosophila melanogaster: evidence for selection mediated by dietary ethanol. Fry JD, et al. Evolution, 2008 Jan. PMID 18070084
  3. Drosophila lacking a homologue of mammalian ALDH2 have multiple fitness defects. Chakraborty M, et al. Chem Biol Interact, 2011 May 30. PMID 21296060, Free PMC Article
  4. Evidence that Environmental Heterogeneity Maintains a Detoxifying Enzyme Polymorphism in Drosophila melanogaster. Chakraborty M, et al. Curr Biol, 2016 Jan 25. PMID 26748852, Free PMC Article
  5. Metabolic control analysis and enzyme variation: nutritional manipulation of the flux from ethanol to lipids in Drosophila. Heinstra PW, et al. Mol Biol Evol, 1991 Sep. PMID 1766365

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila lacking a homologue of mammalian ALDH2 have multiple fitness defects.
    Title: Drosophila lacking a homologue of mammalian ALDH2 have multiple fitness defects.
  2. An amino acid replacement polymorphism in Aldh that shows hallmarks of contributing to clinally varying traits in D. melanogaster was studied.
    Title: A worldwide polymorphism in aldehyde dehydrogenase in Drosophila melanogaster: evidence for selection mediated by dietary ethanol.
  3. Aldh null larvae and adults are poisoned by ethanol concentrations easily tolerated by wild-types; their ethanol sensitivity is comparable to that of Adh nulls suggesting that Aldh and Adh may be equally important in the evolution of ethanol resistance.
    Title: Aldehyde dehydrogenase is essential for both adult and larval ethanol resistance in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetaldehyde dehydrogenase (acetylating) activity IDA
Inferred from Direct Assay
more info
  
enables acetaldehyde dehydrogenase (acetylating) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetaldehyde metabolic process IMP
Inferred from Mutant Phenotype
more info
  
involved_in response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aldehyde dehydrogenase
Names
Aldh-PA
Aldh-PB
CG3752-PA
CG3752-PB
acetaldehyde dehydrogenase
gamma-TriMethylAminoButyrAldehyde DeHydrogenase
NP_001260290.1
NP_609285.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9387389..9391567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135441.2 → NP_609285.1  aldehyde dehydrogenase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609285.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9J7N9, Q9VLC5
    Related
    FBpp0079406
    Conserved Domains (2) summary
    cd07141
    Location:34 → 514
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    PLN02466
    Location:9 → 512
    PLN02466; aldehyde dehydrogenase family 2 member

  2. NM_001273361.1 → NP_001260290.1  aldehyde dehydrogenase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260290.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9J7N9, Q9VLC5
    Conserved Domains (2) summary
    cd07141
    Location:34 → 514
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    PLN02466
    Location:9 → 512
    PLN02466; aldehyde dehydrogenase family 2 member
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLC5 Q9VLC5

Gene LinkOut

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