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Acquired coagulation factor deficiency

MedGen UID:
98
•Concept ID:
C0001169
•
Disease or Syndrome
Synonyms: Acquired clotting factor deficiency; Acquired Coagulation Factor Deficiency; acquired coagulation factor deficiency; acquired coagulation protein disease
SNOMED CT: Acquired clotting factor deficiency (25904003); Acquired coagulation factor deficiency (25904003)
 
Monarch Initiative: MONDO:0020599

Definition

Deficiency of a coagulation factor that is not caused by genetic alterations. Causes include vitamin K deficiency, amyloidosis, and severe liver disease. [from NCI]

Professional guidelines

PubMed

International recommendations on the diagnosis and treatment of acquired hemophilia A.
Tiede A, Collins P, Knoebl P, Teitel J, Kessler C, Shima M, Di Minno G, d'Oiron R, Salaj P, Jiménez-Yuste V, Huth-Kühne A, Giangrande P
Haematologica 2020 Jul;105(7):1791-1801. Epub 2020 May 7 doi: 10.3324/haematol.2019.230771. PMID: 32381574Free PMC Article
Purpura Fulminans: Mechanism and Management of Dysregulated Hemostasis.
Colling ME, Bendapudi PK
Transfus Med Rev 2018 Apr;32(2):69-76. Epub 2017 Oct 16 doi: 10.1016/j.tmrv.2017.10.001. PMID: 29157918
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment.
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ
Med Clin (Barc) 2017 Apr 7;148(7):314-322. Epub 2017 Jan 22 doi: 10.1016/j.medcli.2016.11.030. PMID: 28118963

Recent clinical studies

Etiology

Management of Acquired Factor X Deficiency Caused by In Vitro Non-neutralizing Anti-factor X Autoantibodies with Pre-emptive Corticosteroid Therapy.
Onishi A, Shimura Y, Nakamura T, Souri M, Osaki T, Mizutani S, Tsukamoto T, Kobayashi T, Ichinose A, Kuroda J
Intern Med 2023;62(16):2401-2406. Epub 2023 Aug 15 doi: 10.2169/internalmedicine.0849-22. PMID: 37587057Free PMC Article
Vitamin E-induced coagulopathy in a young patient: a case report.
Abrol R, Kaushik R, Goel D, Sama S, Kaushik RM, Kala M
J Med Case Rep 2023 Mar 23;17(1):107. doi: 10.1186/s13256-023-03827-y. PMID: 36949518Free PMC Article
Clinical characteristics and prognostic factors in intracranial hemorrhage patients with hematological diseases.
Zhang JY, Li Y, Ma YS, Sun XJ, Liu YZ, Yin YK, Hu B, Su MH, Li QL, Mi YC, Li DP
Ann Hematol 2022 Dec;101(12):2617-2625. Epub 2022 Sep 30 doi: 10.1007/s00277-022-04982-w. PMID: 36178488Free PMC Article
Economic burden of major bleeding events in commercially insured patients with von Willebrand disease based on claims data from the United States.
Lu M, Oladapo A, Wu Y, Farahbakhshian S, Ewenstein B
J Manag Care Spec Pharm 2021 Feb;27(2):175-185. Epub 2020 Dec 14 doi: 10.18553/jmcp.2020.20327. PMID: 33307935Free PMC Article
Variability of prothrombin time and activated partial thromboplastin time in the diagnosis of increased surgical bleeding.
Murray D, Pennell B, Olson J
Transfusion 1999 Jan;39(1):56-62. doi: 10.1046/j.1537-2995.1999.39199116895.x. PMID: 9920167

Diagnosis

A Rare Case Report of Acquired Coagulation Factor XI Deficiency.
Zhu W, Deng S, Li J
Clin Lab 2024 Dec 1;70(12) doi: 10.7754/Clin.Lab.2024.240715. PMID: 39662004
Vitamin E-induced coagulopathy in a young patient: a case report.
Abrol R, Kaushik R, Goel D, Sama S, Kaushik RM, Kala M
J Med Case Rep 2023 Mar 23;17(1):107. doi: 10.1186/s13256-023-03827-y. PMID: 36949518Free PMC Article
Economic burden of major bleeding events in commercially insured patients with von Willebrand disease based on claims data from the United States.
Lu M, Oladapo A, Wu Y, Farahbakhshian S, Ewenstein B
J Manag Care Spec Pharm 2021 Feb;27(2):175-185. Epub 2020 Dec 14 doi: 10.18553/jmcp.2020.20327. PMID: 33307935Free PMC Article
Variability of prothrombin time and activated partial thromboplastin time in the diagnosis of increased surgical bleeding.
Murray D, Pennell B, Olson J
Transfusion 1999 Jan;39(1):56-62. doi: 10.1046/j.1537-2995.1999.39199116895.x. PMID: 9920167

Therapy

Vitamin E-induced coagulopathy in a young patient: a case report.
Abrol R, Kaushik R, Goel D, Sama S, Kaushik RM, Kala M
J Med Case Rep 2023 Mar 23;17(1):107. doi: 10.1186/s13256-023-03827-y. PMID: 36949518Free PMC Article
Successful treatment of severe lung hemorrhage caused by acquired factor V inhibitor with rituximab.
Yamada Y, Miyakawa Y, Sawano M, Okano Y
Intern Med 2014;53(10):1083-5. doi: 10.2169/internalmedicine.53.1552. PMID: 24827490
Heparin-induced effects of prothrombin complex concentrates in thromboelastometry.
Scharbert G, Thaler U, Weilnböck C, Wetzel L, Kozek-Langenecker S
Wien Klin Wochenschr 2012 May;124(9-10):320-5. Epub 2012 May 11 doi: 10.1007/s00508-012-0171-8. PMID: 22576961
Variability of prothrombin time and activated partial thromboplastin time in the diagnosis of increased surgical bleeding.
Murray D, Pennell B, Olson J
Transfusion 1999 Jan;39(1):56-62. doi: 10.1046/j.1537-2995.1999.39199116895.x. PMID: 9920167

Prognosis

Clinical characteristics and prognostic factors in intracranial hemorrhage patients with hematological diseases.
Zhang JY, Li Y, Ma YS, Sun XJ, Liu YZ, Yin YK, Hu B, Su MH, Li QL, Mi YC, Li DP
Ann Hematol 2022 Dec;101(12):2617-2625. Epub 2022 Sep 30 doi: 10.1007/s00277-022-04982-w. PMID: 36178488Free PMC Article
Economic burden of major bleeding events in commercially insured patients with von Willebrand disease based on claims data from the United States.
Lu M, Oladapo A, Wu Y, Farahbakhshian S, Ewenstein B
J Manag Care Spec Pharm 2021 Feb;27(2):175-185. Epub 2020 Dec 14 doi: 10.18553/jmcp.2020.20327. PMID: 33307935Free PMC Article

Clinical prediction guides

Economic burden of major bleeding events in commercially insured patients with von Willebrand disease based on claims data from the United States.
Lu M, Oladapo A, Wu Y, Farahbakhshian S, Ewenstein B
J Manag Care Spec Pharm 2021 Feb;27(2):175-185. Epub 2020 Dec 14 doi: 10.18553/jmcp.2020.20327. PMID: 33307935Free PMC Article
Heparin-induced effects of prothrombin complex concentrates in thromboelastometry.
Scharbert G, Thaler U, Weilnböck C, Wetzel L, Kozek-Langenecker S
Wien Klin Wochenschr 2012 May;124(9-10):320-5. Epub 2012 May 11 doi: 10.1007/s00508-012-0171-8. PMID: 22576961

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