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Factor I Inactivation

MedGen UID:
1372006
•Concept ID:
C4329963
•
Disease or Syndrome

Definition

Presence of inactivating antibodies to fibrinogen (factor I) in the blood. [from NCI]

Professional guidelines

PubMed

An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice.
Joseph BC, Miyazawa BY, Esmon CT, Cohen MJ, von Drygalski A, Mosnier LO
Blood Adv 2022 Feb 8;6(3):959-969. doi: 10.1182/bloodadvances.2021005257. PMID: 34861695Free PMC Article
Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Genetic characterization of growth hormone deficiency and resistance: implications for treatment with recombinant growth hormone.
Baumann G
Am J Pharmacogenomics 2002;2(2):93-111. doi: 10.2165/00129785-200202020-00003. PMID: 12083945

Recent clinical studies

Etiology

Long-Term Efficacy of Teprotumumab in Thyroid Eye Disease: Follow-Up Outcomes in Three Clinical Trials.
Kahaly GJ, Subramanian PS, Conrad E, Holt RJ, Smith TJ
Thyroid 2024 Jul;34(7):880-889. Epub 2024 Jun 2 doi: 10.1089/thy.2023.0656. PMID: 38824618
Correlation between asparaginase enzyme activity levels and coagulation parameters during childhood acute lymphoblastic leukemia treatment.
Højfeldt SG, Grell K, Hvitfeldt L, Wehner PS, Bjerre J, Albertsen BK
Pediatr Blood Cancer 2023 Feb;70(2):e30085. Epub 2022 Nov 15 doi: 10.1002/pbc.30085. PMID: 36377699
Is the COVID-19 thrombotic catastrophe complement-connected?
Conway EM, Pryzdial ELG
J Thromb Haemost 2020 Nov;18(11):2812-2822. Epub 2020 Sep 18 doi: 10.1111/jth.15050. PMID: 32762081Free PMC Article
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P
Clin Chim Acta 2013 Sep 23;424:53-65. Epub 2013 May 10 doi: 10.1016/j.cca.2013.05.002. PMID: 23669186
Inactivation of viruses in fresh-frozen plasma.
Wieding JU, Hellstern P, Köhler M
Ann Hematol 1993 Dec;67(6):259-66. doi: 10.1007/BF01696345. PMID: 8280811

Diagnosis

Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway.
Zheng X, Luo Y, Xiong Y, Liu X, Zeng C, Lu X, Wang X, Cheng Y, Wang S, Lan H, Wang K, Weng Z, Bi W, Gan X, Jia X, Wang L, Wang Y
J Immunother Cancer 2023 Dec 6;11(12) doi: 10.1136/jitc-2023-007678. PMID: 38056895Free PMC Article
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P
Clin Chim Acta 2013 Sep 23;424:53-65. Epub 2013 May 10 doi: 10.1016/j.cca.2013.05.002. PMID: 23669186
Current issues on molecular diagnosis of GH signaling defects.
Feigerlova E, Hwa V, Derr MA, Rosenfeld RG
Endocr Dev 2013;24:118-27. Epub 2013 Feb 1 doi: 10.1159/000342586. PMID: 23392100
Fibrinogen has chaperone-like activity.
Tang H, Fu Y, Cui Y, He Y, Zeng X, Ploplis VA, Castellino FJ, Luo Y
Biochem Biophys Res Commun 2009 Jan 16;378(3):662-7. Epub 2008 Dec 4 doi: 10.1016/j.bbrc.2008.11.112. PMID: 19059206Free PMC Article
Congenital afibrinogenemia.
al-Mondhiry H, Ehmann WC
Am J Hematol 1994 Aug;46(4):343-7. doi: 10.1002/ajh.2830460416. PMID: 8037188

Therapy

Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway.
Zheng X, Luo Y, Xiong Y, Liu X, Zeng C, Lu X, Wang X, Cheng Y, Wang S, Lan H, Wang K, Weng Z, Bi W, Gan X, Jia X, Wang L, Wang Y
J Immunother Cancer 2023 Dec 6;11(12) doi: 10.1136/jitc-2023-007678. PMID: 38056895Free PMC Article
The AR/miR-221/IGF-1 pathway mediates the pathogenesis of androgenetic alopecia.
Li K, Sun Y, Liu S, Zhou Y, Qu Q, Wang G, Wang J, Chen R, Fan Z, Liu B, Li Y, Mao X, Hu Z, Miao Y
Int J Biol Sci 2023;19(11):3307-3323. Epub 2023 Jun 26 doi: 10.7150/ijbs.80481. PMID: 37496996Free PMC Article
Is the COVID-19 thrombotic catastrophe complement-connected?
Conway EM, Pryzdial ELG
J Thromb Haemost 2020 Nov;18(11):2812-2822. Epub 2020 Sep 18 doi: 10.1111/jth.15050. PMID: 32762081Free PMC Article
Cryoprecipitate therapy.
Nascimento B, Goodnough LT, Levy JH
Br J Anaesth 2014 Dec;113(6):922-34. Epub 2014 Jun 27 doi: 10.1093/bja/aeu158. PMID: 24972790Free PMC Article
Congenital afibrinogenemia.
al-Mondhiry H, Ehmann WC
Am J Hematol 1994 Aug;46(4):343-7. doi: 10.1002/ajh.2830460416. PMID: 8037188

Prognosis

Long-Term Efficacy of Teprotumumab in Thyroid Eye Disease: Follow-Up Outcomes in Three Clinical Trials.
Kahaly GJ, Subramanian PS, Conrad E, Holt RJ, Smith TJ
Thyroid 2024 Jul;34(7):880-889. Epub 2024 Jun 2 doi: 10.1089/thy.2023.0656. PMID: 38824618
Cocaine-associated atypical haemolytic uraemic syndrome in a genetically susceptible individual.
Bongetti E, Kavanagh D, Martin K, Bendall A, Hill P, Steinberg A, Rajaram Y, Ierino F
Nephrology (Carlton) 2020 Jul;25(7):518-521. Epub 2020 Jan 17 doi: 10.1111/nep.13690. PMID: 31900968
The IGF-p53 connection in cancer.
Conover CA
Growth Horm IGF Res 2018 Apr;39:25-28. Epub 2017 Dec 2 doi: 10.1016/j.ghir.2017.11.007. PMID: 29273484
The Role of Growth Hormone and Insulin-Like Growth Factor-I in the Liver.
Takahashi Y
Int J Mol Sci 2017 Jul 5;18(7) doi: 10.3390/ijms18071447. PMID: 28678199Free PMC Article
Congenital afibrinogenemia.
al-Mondhiry H, Ehmann WC
Am J Hematol 1994 Aug;46(4):343-7. doi: 10.1002/ajh.2830460416. PMID: 8037188

Clinical prediction guides

Long-Term Efficacy of Teprotumumab in Thyroid Eye Disease: Follow-Up Outcomes in Three Clinical Trials.
Kahaly GJ, Subramanian PS, Conrad E, Holt RJ, Smith TJ
Thyroid 2024 Jul;34(7):880-889. Epub 2024 Jun 2 doi: 10.1089/thy.2023.0656. PMID: 38824618
Association of inactivated COVID-19 vaccination with maternal coagulation function in early pregnancy.
Zhao Y, Zhao Y, Zhu J, Lei L, Zhang B, Xu X, Jin L
J Med Virol 2023 Aug;95(8):e29051. doi: 10.1002/jmv.29051. PMID: 37621030
Mast Cell and Basophil Granule Proteases - In Vivo Targets and Function.
Hellman L, Akula S, Fu Z, Wernersson S
Front Immunol 2022;13:918305. Epub 2022 Jul 5 doi: 10.3389/fimmu.2022.918305. PMID: 35865537Free PMC Article
Magnetic bead based assays for complement component C5.
DiScipio RG, Schraufstatter IU
J Immunol Methods 2017 Nov;450:50-57. Epub 2017 Jul 27 doi: 10.1016/j.jim.2017.07.010. PMID: 28757372
Anticoagulant effects of statins and their clinical implications.
Undas A, Brummel-Ziedins KE, Mann KG
Thromb Haemost 2014 Mar 3;111(3):392-400. Epub 2013 Nov 28 doi: 10.1160/TH13-08-0720. PMID: 24285296

Recent systematic reviews

Aspirin Resistance: Cardiovascular Risk Game Changer.
Yassin AS, Abubakar H, Mishra T, Subahi A, Hartman M, Ahmed A, Ibrahim W, Singh M, Pahuja M
Am J Ther 2019 Sep/Oct;26(5):593-599. doi: 10.1097/MJT.0000000000000780. PMID: 29757761
Effects of statins on nonlipid serum markers associated with cardiovascular disease: a systematic review.
Balk EM, Lau J, Goudas LC, Jordan HS, Kupelnick B, Kim LU, Karas RH
Ann Intern Med 2003 Oct 21;139(8):670-82. doi: 10.7326/0003-4819-139-8-200310210-00011. PMID: 14568856

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