U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acquired hypoprothrombinemia

MedGen UID:
140275
•Concept ID:
C0392610
•
Disease or Syndrome
Synonyms: Acquired factor II deficiency; Acquired prothrombin deficiency
SNOMED CT: Acquired factor II deficiency (191298004); Acquired prothrombin deficiency (191298004); Acquired hypoprothrombinemia (191298004)
 
Monarch Initiative: MONDO:0016990
Orphanet: ORPHA26348

Definition

An acquired coagulation disorder characterized by the partial or complete absence of prothrombin (factor II) activity in the blood. [from NCI]

Recent clinical studies

Etiology

The Glasgow Outcome Scale-Extended Pediatric Scores of Intracranial Bleeding Patients with Acquired Prothrombin Complex Deficiency Post Craniotomy and Duraplasty.
Sinurat R
Pediatr Neurosurg 2020;55(5):254-258. Epub 2020 Nov 10 doi: 10.1159/000511020. PMID: 33171478
Lupus anticoagulant-hypoprothrombinemia syndrome: report of two cases and review of the literature.
Mulliez SM, De Keyser F, Verbist C, Vantilborgh A, Wijns W, Beukinga I, Devreese KM
Lupus 2015 Jun;24(7):736-45. Epub 2014 Nov 12 doi: 10.1177/0961203314558859. PMID: 25391540
Lupus anticoagulant-hypoprothrombinemia syndrome: report of 8 cases and review of the literature.
Mazodier K, Arnaud L, Mathian A, Costedoat-Chalumeau N, Haroche J, Frances C, Harlé JR, Pernod G, Lespessailles E, Gaudin P, Charlanne H, Hachulla E, Niaudet P, Piette JC, Amoura Z
Medicine (Baltimore) 2012 Sep;91(5):251-260. doi: 10.1097/MD.0b013e31826b971f. PMID: 22932789
Iatrogenic vitamin K deficiency and life threatening coagulopathy.
Ford SJ, Webb A, Payne R, Blesing N
BMJ Case Rep 2008;2008:bcr0620080008. Epub 2008 Nov 20 doi: 10.1136/bcr.06.2008.0008. PMID: 21687331Free PMC Article
Prothrombin complex concentrates in acquired hypoprothrombinemia.
Sandler SG, Rath CE, Ruder A
Ann Intern Med 1973 Oct;79(4):485-91. doi: 10.7326/0003-4819-79-4-485. PMID: 4748270

Diagnosis

Lupus Anticoagulant-hypoprothrombinemia Syndrome (LAC-HPS) in Children With Systemic Lupus Erythematosus: Report of 3 Cases.
Komvilaisak P, Wisanuyotin S, Jettrisuparb A, Wiangnon S
J Pediatr Hematol Oncol 2017 Nov;39(8):e521-e524. doi: 10.1097/MPH.0000000000000891. PMID: 28787393
Bruised Black and Blue: Acquired Hypoprothrombinemia.
Huang LW, Anand S, Hassan S, Onwuemene O
Am J Med 2015 Nov;128(11):e7-e11. Epub 2015 Jul 6 doi: 10.1016/j.amjmed.2015.06.011. PMID: 26159638
Lupus anticoagulant-hypoprothrombinemia syndrome: report of two cases and review of the literature.
Mulliez SM, De Keyser F, Verbist C, Vantilborgh A, Wijns W, Beukinga I, Devreese KM
Lupus 2015 Jun;24(7):736-45. Epub 2014 Nov 12 doi: 10.1177/0961203314558859. PMID: 25391540
Lupus anticoagulant-hypoprothrombinemia syndrome: report of 8 cases and review of the literature.
Mazodier K, Arnaud L, Mathian A, Costedoat-Chalumeau N, Haroche J, Frances C, Harlé JR, Pernod G, Lespessailles E, Gaudin P, Charlanne H, Hachulla E, Niaudet P, Piette JC, Amoura Z
Medicine (Baltimore) 2012 Sep;91(5):251-260. doi: 10.1097/MD.0b013e31826b971f. PMID: 22932789
Severe bleeding due to acquired hypoprothrombinemia-lupus anticoagulant syndrome. Case report and review of literature.
Vivaldi P, Rossetti G, Galli M, Finazzi G
Haematologica 1997 May-Jun;82(3):345-7. PMID: 9234588

Therapy

Lupus Anticoagulant-hypoprothrombinemia Syndrome (LAC-HPS) in Children With Systemic Lupus Erythematosus: Report of 3 Cases.
Komvilaisak P, Wisanuyotin S, Jettrisuparb A, Wiangnon S
J Pediatr Hematol Oncol 2017 Nov;39(8):e521-e524. doi: 10.1097/MPH.0000000000000891. PMID: 28787393
Iatrogenic vitamin K deficiency and life threatening coagulopathy.
Ford SJ, Webb A, Payne R, Blesing N
BMJ Case Rep 2008;2008:bcr0620080008. Epub 2008 Nov 20 doi: 10.1136/bcr.06.2008.0008. PMID: 21687331Free PMC Article
Severe bleeding due to acquired hypoprothrombinemia-lupus anticoagulant syndrome. Case report and review of literature.
Vivaldi P, Rossetti G, Galli M, Finazzi G
Haematologica 1997 May-Jun;82(3):345-7. PMID: 9234588
Acquired hypoprothrombinemia: effects of danazol treatment.
Williams S, Linardic C, Wilson O, Comp P, Gralnick HR
Am J Hematol 1996 Dec;53(4):272-6. doi: 10.1002/(SICI)1096-8652(199612)53:4<272::AID-AJH14>3.0.CO;2-E. PMID: 8948670
Prothrombin complex concentrates in acquired hypoprothrombinemia.
Sandler SG, Rath CE, Ruder A
Ann Intern Med 1973 Oct;79(4):485-91. doi: 10.7326/0003-4819-79-4-485. PMID: 4748270

Prognosis

Lupus anticoagulant acquired hypoprothrombinemia syndrome in childhood: two distinct patterns and review of the literature.
Sarker T, Roy S, Hollon W, Rajpurkar M
Haemophilia 2015 Nov;21(6):754-60. Epub 2015 Apr 30 doi: 10.1111/hae.12669. PMID: 25929557
Lupus anticoagulant-hypoprothrombinemia syndrome: report of two cases and review of the literature.
Mulliez SM, De Keyser F, Verbist C, Vantilborgh A, Wijns W, Beukinga I, Devreese KM
Lupus 2015 Jun;24(7):736-45. Epub 2014 Nov 12 doi: 10.1177/0961203314558859. PMID: 25391540

Clinical prediction guides

The Glasgow Outcome Scale-Extended Pediatric Scores of Intracranial Bleeding Patients with Acquired Prothrombin Complex Deficiency Post Craniotomy and Duraplasty.
Sinurat R
Pediatr Neurosurg 2020;55(5):254-258. Epub 2020 Nov 10 doi: 10.1159/000511020. PMID: 33171478
Lupus anticoagulant acquired hypoprothrombinemia syndrome in childhood: two distinct patterns and review of the literature.
Sarker T, Roy S, Hollon W, Rajpurkar M
Haemophilia 2015 Nov;21(6):754-60. Epub 2015 Apr 30 doi: 10.1111/hae.12669. PMID: 25929557

Supplemental Content

Table of contents

    Clinical resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...