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Factor V Inactivation

MedGen UID:
1378842
•Concept ID:
C4329967
•
Disease or Syndrome

Definition

Presence of inactivating antibodies to factor V in the blood. [from NCI]

Professional guidelines

PubMed

The Magic of Proteases: From a Procoagulant and Anticoagulant Factor V to an Equitable Treatment of Its Inherited Deficiency.
De Pablo-Moreno JA, Miguel-Batuecas A, de Sancha M, Liras A
Int J Mol Sci 2023 Mar 26;24(7) doi: 10.3390/ijms24076243. PMID: 37047215Free PMC Article
Design and characterization of an APC-specific serpin for the treatment of hemophilia.
Polderdijk SG, Adams TE, Ivanciu L, Camire RM, Baglin TP, Huntington JA
Blood 2017 Jan 5;129(1):105-113. Epub 2016 Oct 27 doi: 10.1182/blood-2016-05-718635. PMID: 27789479Free PMC Article
Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article

Recent clinical studies

Etiology

Plasma contact activation and decrease of factor V activity on negatively-charged polyelectrolytes.
Boffa MC, Dreyer B, Pusineri C
Thromb Haemost 1984 Feb 28;51(1):61-4. PMID: 6719390

Clinical prediction guides

Plasma factor V activation is prevented by activated protein C in the presence of phospholipid vesicles, not platelets.
Solymoss S, Nguyen KT
Thromb Haemost 1993 Feb 1;69(2):124-9. PMID: 8456424
Plasma contact activation and decrease of factor V activity on negatively-charged polyelectrolytes.
Boffa MC, Dreyer B, Pusineri C
Thromb Haemost 1984 Feb 28;51(1):61-4. PMID: 6719390

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