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Factor VII Inactivation

MedGen UID:
1391171
•Concept ID:
C4329968
•
Disease or Syndrome

Definition

Presence of inactivating antibodies to factor VII in the blood. [from NCI]

Professional guidelines

PubMed

Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Actual improvements in the treatment of von Willebrand's disease: Wilate--double virus inactivation, high purity and convenience for patients.
Thromb Haemost 2005 Nov;94(5):VII-X. PMID: 16363263
Successful clinical use of a plasma-derived, dual virus inactivated factor VII concentrate incorporating solvent-detergent and dry heat treatment.
Smith MP, Rice KM, Savidge GF
Thromb Haemost 1997 Feb;77(2):406-7. PMID: 9157608

Recent clinical studies

Etiology

The role of tissue factor pathway inhibitor 2 in the coagulation and fibrinolysis system.
Kobayashi H, Matsubara S, Imanaka S
J Obstet Gynaecol Res 2023 Jul;49(7):1677-1683. Epub 2023 Apr 25 doi: 10.1111/jog.15660. PMID: 37186495
Novel Insights and New Developments Regarding Coagulation Revealed by Studies of the Anti-Factor IXa (Activated Factor IX)/Factor X Bispecific Antibody, Emicizumab.
Yada K, Nogami K
Arterioscler Thromb Vasc Biol 2020 May;40(5):1148-1154. Epub 2020 Apr 2 doi: 10.1161/ATVBAHA.120.312919. PMID: 32237902
A review of oral anticoagulants, old and new, in major bleeding and the need for urgent surgery.
Milling TJ Jr, Ziebell CM
Trends Cardiovasc Med 2020 Feb;30(2):86-90. Epub 2019 Mar 26 doi: 10.1016/j.tcm.2019.03.004. PMID: 30952383Free PMC Article
Elevated alpha1-antitrypsin is a risk factor for arterial ischemic stroke in childhood.
Burghaus B, Langer C, Thedieck S, Nowak-Göttl U
Acta Haematol 2006;115(3-4):186-91. doi: 10.1159/000090933. PMID: 16549894
Protein Z: "light and shade" of a new thrombotic factor.
Sofi F, Cesari F, Fedi S, Abbate R, Gensini GF
Clin Lab 2004;50(11-12):647-52. PMID: 15575306

Diagnosis

Novel Insights and New Developments Regarding Coagulation Revealed by Studies of the Anti-Factor IXa (Activated Factor IX)/Factor X Bispecific Antibody, Emicizumab.
Yada K, Nogami K
Arterioscler Thromb Vasc Biol 2020 May;40(5):1148-1154. Epub 2020 Apr 2 doi: 10.1161/ATVBAHA.120.312919. PMID: 32237902
A review of oral anticoagulants, old and new, in major bleeding and the need for urgent surgery.
Milling TJ Jr, Ziebell CM
Trends Cardiovasc Med 2020 Feb;30(2):86-90. Epub 2019 Mar 26 doi: 10.1016/j.tcm.2019.03.004. PMID: 30952383Free PMC Article
Elevated alpha1-antitrypsin is a risk factor for arterial ischemic stroke in childhood.
Burghaus B, Langer C, Thedieck S, Nowak-Göttl U
Acta Haematol 2006;115(3-4):186-91. doi: 10.1159/000090933. PMID: 16549894
Effects of simvastatin or hormone replacement therapy, or both, on fibrinogen, factor VII, and plasminogen activator inhibitor levels in postmenopausal women with proven coronary artery disease.
Sbarouni E, Melissari E, Kyriakides ZS, Kremastinos DT
Am J Cardiol 2000 Jul 1;86(1):80-3. doi: 10.1016/s0002-9149(00)00831-6. PMID: 10867097
Coagulation and fibrinolysis in viable mid-trimester pregnancies of normal, intrauterine growth retardation, chromosomal anomalies and hydrops fetalis and their eventual obstetric outcome.
Koh SC, Anandakumar C, Biswas A
J Perinat Med 1999;27(6):458-64. doi: 10.1515/JPM.1999.061. PMID: 10732304

Therapy

A review of oral anticoagulants, old and new, in major bleeding and the need for urgent surgery.
Milling TJ Jr, Ziebell CM
Trends Cardiovasc Med 2020 Feb;30(2):86-90. Epub 2019 Mar 26 doi: 10.1016/j.tcm.2019.03.004. PMID: 30952383Free PMC Article
Literature review and clinical observation of acquired idiopathic hemophilia with a new missense mutation in the factor VIII gene (His2026Arg).
Ershov VI, Gadaev IY, Perina FG, Surin VL, Salomashkina VV, Pshenichnikova OS, Zozulya NI
Ter Arkh 2018 Aug 17;90(7):118-122. doi: 10.26442/terarkh2018907118-122. PMID: 30701933
Recombinant factor VIIa and other pro-haemostatic therapies in primary postpartum haemorrhage.
Searle E, Pavord S, Alfirevic Z
Best Pract Res Clin Obstet Gynaecol 2008 Dec;22(6):1075-88. Epub 2008 Oct 1 doi: 10.1016/j.bpobgyn.2008.08.010. PMID: 18838340
Effects of simvastatin or hormone replacement therapy, or both, on fibrinogen, factor VII, and plasminogen activator inhibitor levels in postmenopausal women with proven coronary artery disease.
Sbarouni E, Melissari E, Kyriakides ZS, Kremastinos DT
Am J Cardiol 2000 Jul 1;86(1):80-3. doi: 10.1016/s0002-9149(00)00831-6. PMID: 10867097
Anticoagulation: a surgical perspective.
Perry MO
Am J Surg 1988 Feb;155(2):268-76. doi: 10.1016/s0002-9610(88)80712-8. PMID: 3277474

Prognosis

Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk.
Olson NC, Raffield LM, Lange LA, Lange EM, Longstreth WT Jr, Chauhan G, Debette S, Seshadri S, Reiner AP, Tracy RP
J Thromb Haemost 2018 Jan;16(1):19-30. Epub 2017 Dec 8 doi: 10.1111/jth.13899. PMID: 29112333Free PMC Article
Quantitative PET Imaging of Tissue Factor Expression Using 18F-Labeled Active Site-Inhibited Factor VII.
Nielsen CH, Erlandsson M, Jeppesen TE, Jensen MM, Kristensen LK, Madsen J, Petersen LC, Kjaer A
J Nucl Med 2016 Jan;57(1):89-95. Epub 2015 Sep 17 doi: 10.2967/jnumed.115.154849. PMID: 26383146
Elevated alpha1-antitrypsin is a risk factor for arterial ischemic stroke in childhood.
Burghaus B, Langer C, Thedieck S, Nowak-Göttl U
Acta Haematol 2006;115(3-4):186-91. doi: 10.1159/000090933. PMID: 16549894
Anticoagulation proteins C and S.
Esmon CT, Vigano-D'Angelo S, D'Angelo A, Comp PC
Adv Exp Med Biol 1987;214:47-54. doi: 10.1007/978-1-4757-5985-3_4. PMID: 2959034
The activation and inactivation of human factor VIII by thrombin: effect of inhibitors of thrombin.
Hultin MB, Jesty J
Blood 1981 Mar;57(3):476-82. PMID: 6779877

Clinical prediction guides

Literature review and clinical observation of acquired idiopathic hemophilia with a new missense mutation in the factor VIII gene (His2026Arg).
Ershov VI, Gadaev IY, Perina FG, Surin VL, Salomashkina VV, Pshenichnikova OS, Zozulya NI
Ter Arkh 2018 Aug 17;90(7):118-122. doi: 10.26442/terarkh2018907118-122. PMID: 30701933
Tissue factor pathway inhibitor is an inhibitor of factor VII-activating protease.
Stephan F, Dienava-Verdoold I, Bulder I, Wouters D, Mast AE, Te Velthuis H, Aarden LA, Zeerleder S
J Thromb Haemost 2012 Jun;10(6):1165-71. doi: 10.1111/j.1538-7836.2012.04712.x. PMID: 22449009Free PMC Article
Elevated alpha1-antitrypsin is a risk factor for arterial ischemic stroke in childhood.
Burghaus B, Langer C, Thedieck S, Nowak-Göttl U
Acta Haematol 2006;115(3-4):186-91. doi: 10.1159/000090933. PMID: 16549894
Sources of tissue factor.
Østerud B, Bjørklid E
Semin Thromb Hemost 2006 Feb;32(1):11-23. doi: 10.1055/s-2006-933336. PMID: 16479458
Coagulation and fibrinolysis in viable mid-trimester pregnancies of normal, intrauterine growth retardation, chromosomal anomalies and hydrops fetalis and their eventual obstetric outcome.
Koh SC, Anandakumar C, Biswas A
J Perinat Med 1999;27(6):458-64. doi: 10.1515/JPM.1999.061. PMID: 10732304

Recent systematic reviews

Clinical review: Clinical management of new oral anticoagulants: a structured review with emphasis on the reversal of bleeding complications.
Lazo-Langner A, Lang ES, Douketis J
Crit Care 2013 Jun 17;17(3):230. doi: 10.1186/cc12592. PMID: 23806169Free PMC Article

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