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Factor XIII Inactivation

MedGen UID:
1389097
•Concept ID:
C4329973
•
Disease or Syndrome

Definition

Presence of inactivating antibodies to factor XIII in the blood. [from NCI]

Professional guidelines

PubMed

Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Diagnosis and Management of Congenital and Acquired FXIII Deficiencies.
Muszbek L, Katona É
Semin Thromb Hemost 2016 Jun;42(4):429-39. Epub 2016 Apr 12 doi: 10.1055/s-0036-1572326. PMID: 27071048
Tri(n-butyl) phosphate/detergent treatment of licensed therapeutic and experimental blood derivatives.
Edwards CA, Piet MP, Chin S, Horowitz B
Vox Sang 1987;52(1-2):53-9. doi: 10.1111/j.1423-0410.1987.tb02989.x. PMID: 3111089

Recent clinical studies

Etiology

Analysis of thrombophilic gene mutations in coronary artery ectasia.
Yalım Z, Tutgun Onrat S, Emren SV, Dural İE, Avşar A, Onrat E
Turk Kardiyol Dern Ars 2020 Jun;48(4):368-373. doi: 10.5543/tkda.2019.99789. PMID: 32525847
Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Diagnosis and Management of Congenital and Acquired FXIII Deficiencies.
Muszbek L, Katona É
Semin Thromb Hemost 2016 Jun;42(4):429-39. Epub 2016 Apr 12 doi: 10.1055/s-0036-1572326. PMID: 27071048
Anticoagulant effects of statins and their clinical implications.
Undas A, Brummel-Ziedins KE, Mann KG
Thromb Haemost 2014 Mar 3;111(3):392-400. Epub 2013 Nov 28 doi: 10.1160/TH13-08-0720. PMID: 24285296
Plasma derivatives and viral hepatitis.
Gerety RJ, Aronson DL
Transfusion 1982 Sep-Oct;22(5):347-51. doi: 10.1046/j.1537-2995.1982.22583017454.x. PMID: 6812245

Diagnosis

Analysis of thrombophilic gene mutations in coronary artery ectasia.
Yalım Z, Tutgun Onrat S, Emren SV, Dural İE, Avşar A, Onrat E
Turk Kardiyol Dern Ars 2020 Jun;48(4):368-373. doi: 10.5543/tkda.2019.99789. PMID: 32525847
Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Diagnosis and Management of Congenital and Acquired FXIII Deficiencies.
Muszbek L, Katona É
Semin Thromb Hemost 2016 Jun;42(4):429-39. Epub 2016 Apr 12 doi: 10.1055/s-0036-1572326. PMID: 27071048
The safety of fibrin sealants.
Joch C
Cardiovasc Surg 2003 Aug;11 Suppl 1:23-8. doi: 10.1016/S0967-2109(03)00068-1. PMID: 12869985
Inhibitors to clotting factors.
Sallah S
Ann Hematol 1997 Jul-Aug;75(1-2):1-7. doi: 10.1007/s002770050305. PMID: 9322677

Therapy

Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Cryoprecipitate therapy.
Nascimento B, Goodnough LT, Levy JH
Br J Anaesth 2014 Dec;113(6):922-34. Epub 2014 Jun 27 doi: 10.1093/bja/aeu158. PMID: 24972790Free PMC Article
Anticoagulant effects of statins and their clinical implications.
Undas A, Brummel-Ziedins KE, Mann KG
Thromb Haemost 2014 Mar 3;111(3):392-400. Epub 2013 Nov 28 doi: 10.1160/TH13-08-0720. PMID: 24285296
Inhibitors to clotting factors.
Sallah S
Ann Hematol 1997 Jul-Aug;75(1-2):1-7. doi: 10.1007/s002770050305. PMID: 9322677
Plasma derivatives and viral hepatitis.
Gerety RJ, Aronson DL
Transfusion 1982 Sep-Oct;22(5):347-51. doi: 10.1046/j.1537-2995.1982.22583017454.x. PMID: 6812245

Prognosis

Thromboelastography used to assess coagulation during treatment with molecular adsorbent recirculating system.
Doria C, Mandalà L, Smith JD, Caruana G, Scott VL, Gruttadauria S, Magnone M, Marino IR
Clin Transplant 2004 Aug;18(4):365-71. doi: 10.1111/j.1399-0012.2004.00172.x. PMID: 15233811
Blood coagulation at the site of microvascular injury: effects of low-dose aspirin.
Undas A, Brummel K, Musial J, Mann KG, Szczeklik A
Blood 2001 Oct 15;98(8):2423-31. doi: 10.1182/blood.v98.8.2423. PMID: 11588039
Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor XIII and by enhancing factor Va inactivation.
Undas A, Brummel KE, Musial J, Mann KG, Szczeklik A
Circulation 2001 May 8;103(18):2248-53. doi: 10.1161/01.cir.103.18.2248. PMID: 11342472
Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.
Medof ME, Lublin DM, Holers VM, Ayers DJ, Getty RR, Leykam JF, Atkinson JP, Tykocinski ML
Proc Natl Acad Sci U S A 1987 Apr;84(7):2007-11. doi: 10.1073/pnas.84.7.2007. PMID: 2436222Free PMC Article
Diagnostic and genetic studies on fibrin-stabilizing factor with a new assay based on amine incorporation.
Lorand L, Urayama T, De Kiewiet JW, Nossel HL
J Clin Invest 1969 Jun;48(6):1054-64. doi: 10.1172/JCI106061. PMID: 4977030Free PMC Article

Clinical prediction guides

Crosstalk among WEE1 Kinase, AKT, and GSK3 in Nav1.2 Channelosome Regulation.
Singh AK, Singh J, Goode NA, Laezza F
Int J Mol Sci 2024 Jul 24;25(15) doi: 10.3390/ijms25158069. PMID: 39125637Free PMC Article
Anticoagulant effects of statins and their clinical implications.
Undas A, Brummel-Ziedins KE, Mann KG
Thromb Haemost 2014 Mar 3;111(3):392-400. Epub 2013 Nov 28 doi: 10.1160/TH13-08-0720. PMID: 24285296
Platelet accumulation on fibrin-coated polyethylene: role of platelet activation and factor XIII.
Rubens FD, Perry DW, Hatton MW, Bishop PD, Packham MA, Kinlough-Rathbone RL
Thromb Haemost 1995 May;73(5):850-6. PMID: 7482415
Activated protein C increases fibrin clot lysis by neutralization of plasminogen activator inhibitor--no evidence for a cofactor role of protein S.
de Fouw NJ, de Jong YF, Haverkate F, Bertina RM
Thromb Haemost 1988 Oct 31;60(2):328-33. PMID: 2975409
Plasma factor XIII and some other haemostasis parameters in patients with diabetic angiopathy.
Kłoczko J, Wojtukiewicz M, Bielawiec M, Zarzycka B, Kinalska I
Acta Haematol 1986;76(2-3):81-5. doi: 10.1159/000206026. PMID: 2433883

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