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    lola longitudinals lacking [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44548, updated on 17-Dec-2024

    Summary

    Official Symbol
    lolaprovided by FlyBase
    Official Full Name
    longitudinals lackingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283521
    Locus tag
    Dmel_CG12052
    See related
    AllianceGenome:FB:FBgn0283521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD17006; BcDNA:RH31485; BEST:LD03274; bs06a08.y1; btb; BTB-IV; BtbIV; CG12052; CG18376; CG18378; CG18379; CG18380; CG18381; CG30012; CG30013; CG30014; Dmel\CG12052; eyeful; fus7; l(2)00642; l(2)s3697; LD03274; Lola; LOLA; NEST:bs06a08; sw59
    Summary
    Enables DNA binding activity. Involved in several processes, including larval development; neuron differentiation; and nurse cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; central nervous system; male germline cell; sensory neurons; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See lola in Genome Data Viewer
    Location:
    47A11-47A13; 2-62 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10481894..10543291, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6369399..6430796, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pre-lola-G Neighboring gene translin Neighboring gene Peflin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene antisense RNA:CR45135 Neighboring gene long non-coding RNA:acal Neighboring gene pipsqueak

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in R3/R4 cell fate commitment PubMed 
    involved_in R7 cell development PubMed 
    involved_in axon guidance PubMed 
    involved_in axon guidance PubMed 
    involved_in axon midline choice point recognition PubMed 
    involved_in axon midline choice point recognition PubMed 
    involved_in axonogenesis PubMed 
    involved_in dendrite morphogenesis PubMed 
    involved_in gonad development PubMed 
    involved_in larval lymph gland hemopoiesis PubMed 
    involved_in larval somatic muscle development PubMed 
    involved_in larval somatic muscle development PubMed 
    involved_in nurse cell apoptotic process PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria PubMed 
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway PubMed 
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of axon guidance PubMed 
    involved_in regulation of gene expression PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in nucleoplasm PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    longitudinals lacking
    Names
    BTB-protein-IV
    CG12052-PA
    CG12052-PAA
    CG12052-PB
    CG12052-PC
    CG12052-PD
    CG12052-PE
    CG12052-PF
    CG12052-PG
    CG12052-PH
    CG12052-PI
    CG12052-PJ
    CG12052-PK
    CG12052-PL
    CG12052-PM
    CG12052-PO
    CG12052-PP
    CG12052-PQ
    CG12052-PR
    CG12052-PT
    CG12052-PU
    CG12052-PV
    CG12052-PW
    CG12052-PX
    CG12052-PY
    CG12052-PZ
    SGP cluster fusion defects 7
    bumper-to-bumper
    e
    eyeful
    lola
    lola-PA
    lola-PAA
    lola-PB
    lola-PC
    lola-PD
    lola-PE
    lola-PF
    lola-PG
    lola-PH
    lola-PI
    lola-PJ
    lola-PK
    lola-PL
    lola-PM
    lola-PO
    lola-PP
    lola-PQ
    lola-PR
    lola-PT
    lola-PU
    lola-PV
    lola-PW
    lola-PX
    lola-PY
    lola-PZ
    longitudinal lacking
    longitudinals absent
    longitudinals-lacking
    misguided

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10481894..10543291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080027.6 → NP_524766.2  longitudinals lacking, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524766.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42283, Q54A11, Q9V5M2
      Conserved Domains (4) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:793 → 813
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
      pfam13909
      Location:821 → 844
      zf-H2C2_5; C2H2-type zinc-finger domain
    2. NM_176132.4 → NP_788312.2  longitudinals lacking, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788312.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42283, Q54A11, Q9V5M2
      Conserved Domains (4) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:793 → 813
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
      pfam13909
      Location:821 → 844
      zf-H2C2_5; C2H2-type zinc-finger domain
    3. NM_206083.4 → NP_995805.1  longitudinals lacking, isoform X [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995805.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V5M3
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
      pfam13909
      Location:576 → 598
      zf-H2C2_5; C2H2-type zinc-finger domain
    4. NM_206082.4 → NP_995804.1  longitudinals lacking, isoform Y [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995804.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V5M3
      Conserved Domains (4) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:466 → 484
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
      pfam13894
      Location:493 → 515
      zf-C2H2_4; C2H2-type zinc finger
    5. NM_206084.4 → NP_995806.1  longitudinals lacking, isoform W [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KQY7, Q7KQY8, Q867I9, Q867J2, Q867U5, Q867Y0, Q86BC4, Q9V5M3
      Conserved Domains (4) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:711 → 727
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
      pfam13909
      Location:738 → 761
      zf-H2C2_5; C2H2-type zinc-finger domain
    6. NM_176129.5 → NP_788309.2  longitudinals lacking, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788309.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V5M3
      Related
      FBpp0088395
      Conserved Domains (4) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:532 → 552
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
      pfam12171
      Location:532 → 560
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    7. NM_176130.5 → NP_788310.2  longitudinals lacking, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788310.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V5M6
      Related
      FBpp0088394
      Conserved Domains (4) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:705 → 725
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:732 → 754
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    8. NM_176131.5 → NP_788311.2  longitudinals lacking, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788311.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q058V9, Q4AB07, Q867J5, Q867M8, Q867P1, Q867T8, Q86BC2, Q8MKX4, Q9V5M5, Q9V5M6
      Related
      FBpp0088389
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:851 → 871
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    9. NM_170617.5 → NP_724945.1  longitudinals lacking, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42284
      Related
      FBpp0088380
      Conserved Domains (2) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    10. NM_170618.5 → NP_724946.1  longitudinals lacking, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724946.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZC4, Q0E9C9, Q7KQZ4, Q867I7, Q867S0, Q867S9, Q8MKX5, Q95TS0
      Related
      FBpp0088379
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:687 → 707
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    11. NM_170619.3 → NP_724949.2  longitudinals lacking, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724949.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZC4, Q0E9C9, Q7KQZ4, Q867I7, Q867S0, Q867S9, Q8MKX5, Q95TS0
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:687 → 707
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    12. NM_176128.5 → NP_788308.3  longitudinals lacking, isoform AA [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788308.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZC3, Q867F7, Q867K2, Q867T0, Q867Z4, Q86BC3, Q8MKX6, Q8MZH5
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:905 → 925
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    13. NM_176133.5 → NP_788313.1  longitudinals lacking, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788313.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZC3, Q867F7, Q867K2, Q867T0, Q867Z4, Q86BC3, Q8MKX6, Q8MZH5
      Related
      FBpp0088384
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:905 → 925
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    14. NM_176134.4 → NP_788314.1  longitudinals lacking, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788314.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q867Z4
      Related
      FBpp0088393
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    15. NM_176135.4 → NP_788315.1  longitudinals lacking, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q867Z4
      Related
      FBpp0088385
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    16. NM_170622.6 → NP_724952.2  longitudinals lacking, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724952.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q867Z4
      Related
      FBpp0088382
      Conserved Domains (5) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:507 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:536 → 555
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
      pfam13465
      Location:521 → 547
      zf-H2C2_2; Zinc-finger double domain
    17. NM_176136.5 → NP_788316.2  longitudinals lacking, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788316.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q867Z4
      Related
      FBpp0088387
      Conserved Domains (4) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:465 → 488
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:495 → 517
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    18. NM_206085.4 → NP_995807.1  longitudinals lacking, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42284, Q867M9, Q867R1, Q868A5
      Conserved Domains (2) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    19. NM_170620.4 → NP_724950.1  longitudinals lacking, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KQZ4
      Related
      FBpp0088383
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:481 → 501
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    20. NM_170621.4 → NP_724951.1  longitudinals lacking, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724951.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KQZ4
      Related
      FBpp0088376
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:481 → 501
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    21. NM_001032229.3 → NP_001027400.1  longitudinals lacking, isoform Z [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027400.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V5M6
      Conserved Domains (3) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
      pfam13909
      Location:634 → 658
      zf-H2C2_5; C2H2-type zinc-finger domain
    22. NM_170623.6 → NP_724953.2  longitudinals lacking, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724953.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KQZ4
      Related
      FBpp0088378
      Conserved Domains (4) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:528 → 545
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
      pfam05605
      Location:524 → 578
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    23. NM_176138.5 → NP_788318.1  longitudinals lacking, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788318.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KQZ4
      Related
      FBpp0088386
      Conserved Domains (4) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:551 → 571
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578 → 602
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
    24. NM_176139.3 → NP_788319.1  longitudinals lacking, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMG1
      Related
      FBpp0088390
      Conserved Domains (4) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:546 → 564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
      pfam13465
      Location:559 → 584
      zf-H2C2_2; Zinc-finger double domain
    25. NM_176140.4 → NP_788320.1  longitudinals lacking, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788320.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42284
      Related
      FBpp0088396
      Conserved Domains (2) summary
      smart00225
      Location:33 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:22 → 117
      BTB; BTB/POZ domain
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