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B52 B52 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41670, updated on 9-Dec-2024

Summary

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Official Symbol
B52provided by FlyBase
Official Full Name
B52provided by FlyBase
Primary source
FLYBASE:FBgn0004587
Locus tag
Dmel_CG10851
See related
AllianceGenome:FB:FBgn0004587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
B52/dSRp55; B52/SRp55; CG10851; Dmel\CG10851; dSRp55; E(Dfd); E726; l(3)s2249; MabB52; Rbp8; rrm8; RRM8; RSp55; SR55; SRp55; SRSF6
Summary
Enables mRNA binding activity. Involved in several processes, including defense response to virus; mitotic G1/S transition checkpoint signaling; and regulation of RNA metabolic process. Located in euchromatin; nuclear speck; and polytene chromosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; adult heart; embryonic brain; and primary neurons. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to several human genes including SRSF4 (serine and arginine rich splicing factor 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See B52 in Genome Data Viewer
Location:
87F7-87F7; 3-54 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13661311..13666891)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9487033..9492613)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RNA-binding protein 4 Neighboring gene Heterogeneous nuclear ribonucleoprotein at 87F Neighboring gene TWIK-related acid-sensitive K[+] channel 6 Neighboring gene uncharacterized protein Neighboring gene Lkb1 kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a Drosophila protein associated with boundaries of transcriptionally active chromatin. Champlin DT, et al. Genes Dev, 1991 Sep. PMID 1885003
  2. A specific RNA hairpin loop structure binds the RNA recognition motifs of the Drosophila SR protein B52. Shi H, et al. Mol Cell Biol, 1997 May. PMID 9111335, Free PMC Article
  3. A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription. Roth MB, et al. J Cell Biol, 1991 Nov. PMID 1717489, Free PMC Article
  4. Composite RNA aptamers as functional mimics of proteins. Xu D, et al. Nucleic Acids Res, 2009 May. PMID 19380374, Free PMC Article
  5. Regulation of alternative polyadenylation by U1 snRNPs and SRp20. Lou H, et al. Mol Cell Biol, 1998 Sep. PMID 9710581, Free PMC Article

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulation of Yorkie activity by alternative splicing is required for developmental stability.
    Title: Modulation of Yorkie activity by alternative splicing is required for developmental stability.
  2. Loss of B52 increases growth of axon branches. B52 function is also required for Choline acetyltransferase (ChAT ) splicing.
    Title: Single neuron transcriptomics identify SRSF/SR protein B52 as a regulator of axon growth and Choline acetyltransferase splicing.
  3. B52 overexpression increases cell growth, upregulates myc transcription, and gives rise to flies lacking thoracic bristles.
    Title: A role for the serine/arginine-rich (SR) protein B52/SRSF6 in cell growth and myc expression in Drosophila.
  4. B52 delivers Topo I to RNA polymerase II-active chromatin loci and DNA topology and mRNA release can be coordinated to control gene expression.
    Title: The SR protein B52/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown.
  5. B52/SRp55 generates 2 isoforms of eyeless differing by an alternative exon encoding a 60-AA insert at the beginning of the paired domain. In normal eye development B52/SRp55 controls eye organogenesis & size by regulating eyeless alternative splicing.
    Title: Eye development under the control of SRp55/B52-mediated alternative splicing of eyeless.
  6. The SR proteins dASF/SF2 and B52 caused defects in ommatidia structure, and B52 impaired normal axonal projections of photoreceptors and neurogenesis in visual ganglia.
    Title: The SR family proteins B52 and dASF/SF2 modulate development of the Drosophila visual system by regulating specific RNA targets.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G1/S transition checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle HMP PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
B52
Names
B52-PA
B52-PB
B52-PC
B52-PD
B52-PF
B52-PI
B52-PK
B52-PM
B52-PN
B52-PO
CG10851-PA
CG10851-PB
CG10851-PC
CG10851-PD
CG10851-PF
CG10851-PI
CG10851-PK
CG10851-PM
CG10851-PN
CG10851-PO
Monoclonal-antibody-B52
RNA-binding protein 8
Serine/arginine rich protein 55
enhancer of deformed
serine-arginine protein 55
splicing factor B52

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13661311..13666891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176490.3 → NP_788667.2  B52, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788667.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26686
    Conserved Domains (2) summary
    cd12337
    Location:5 → 74
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:115 → 186
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

  2. NM_176494.4 → NP_788671.2  B52, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788671.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHG5
    Conserved Domains (2) summary
    cd12337
    Location:5 → 74
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:120 → 191
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

  3. NM_176491.3 → NP_788668.1  B52, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788668.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26686
    Related
    FBpp0082270
    Conserved Domains (3) summary
    COG0724
    Location:4 → 128
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12337
    Location:5 → 74
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:120 → 191
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

  4. NM_001014619.3 → NP_001014619.2  B52, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014619.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHG5
    Conserved Domains (2) summary
    cd12337
    Location:5 → 74
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:120 → 191
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

  5. NM_001170133.2 → NP_001163604.1  B52, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163604.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26686
    Conserved Domains (3) summary
    COG0724
    Location:4 → 78
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12337
    Location:5 → 74
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cl17169
    Location:115 → 129
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. NM_001170132.2 → NP_001163603.1  B52, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163603.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26686
    Conserved Domains (2) summary
    cd12337
    Location:5 → 74
    RRM1_SRSF4_like; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cl17169
    Location:106 → 131
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. NM_176492.4 → NP_788669.1  B52, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788669.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26686
    Related
    FBpp0082271
    Conserved Domains (2) summary
    cd12337
    Location:5 → 74
    RRM1_SRSF4_like; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cl17169
    Location:106 → 131
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. NM_176488.3 → NP_788665.1  B52, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788665.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26686
    Related
    FBpp0082269
    Conserved Domains (2) summary
    cd12337
    Location:5 → 74
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:115 → 186
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

  9. NM_176493.4 → NP_788670.1  B52, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788670.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26686
    Related
    FBpp0082272
    Conserved Domains (3) summary
    COG0724
    Location:4 → 78
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12337
    Location:5 → 74
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cl17169
    Location:115 → 129
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. NM_176489.3 → NP_788666.1  B52, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788666.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26686
    Related
    FBpp0082274
    Conserved Domains (2) summary
    cd12337
    Location:5 → 74
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:115 → 186
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0C4DHG5 A0A0C4DHG5
P26686.4 P26686

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