H Hairless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hprovided by FlyBase
Official Full Name: Hairlessprovided by FlyBase
Primary source: FLYBASE:FBgn0001169
Locus tag: Dmel_CG5460
See related: AllianceGenome:FB:FBgn0001169
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5460; Dmel\CG5460
Summary: Enables transcription corepressor activity. Involved in several processes, including intestinal stem cell homeostasis; sensory organ precursor cell fate determination; and wing disc development. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including anterior-posterior subdivision of organism; germline cell; gut section; imaginal disc; and stem cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 92F3-92F3; 3-69 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20621938..20628915)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16447660..16454637)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic and Molecular Interactions between H[DeltaCT], a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster.
Title: Genetic and Molecular Interactions between H(ΔCT), a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster.
Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.
Title: Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.
Internal ribosome entry site mediated translation of H protein during mitosis.
Title: In vivo analysis of internal ribosome entry at the Hairless locus by genome engineering in Drosophila.
X-ray structure of the Su(H)-Hairless complex bound to DNA.
Title: Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster.
There are two potential MAPK phosphorylation sites within the H protein; mutation of the two sites had only minor effects on the biological activity of H, suggesting that they are not major targets of MAPK
Title: Mutation of potential MAPK phosphorylation sites in the Notch antagonist Hairless.
Genes activated by Notch signaling at the dorsal-ventral boundary of wing disc fall into classes affected differently by the loss of kinase module subunits. The distinctions do not result from different requirements for Hairless.
Title: Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin.
Data mapped the residues in Suppressor of Hairless Su(H) that contact Hairless, and mutation of these sites neither affects binding to DNA nor to Notch.
Title: Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless.
Data show that the differential recruitment of the co-repressors Gro and CtBP by H in a context-dependent manner ensures fine tuning of Notch signaling activity during eye development.
Title: Fine tuning of Notch signaling by differential co-repressor recruitment during eye development of Drosophila.
we identify a site in Hairless that is crucial for binding Su(H) protein
Title: Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster.
Hairless (H) is a Runt-interacting molecule that functions during segmentation. H is important for maintenance of engrailed (en) repression.
Title: Hairless is a cofactor for Runt-dependent transcriptional regulation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory organ boundary specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed