BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  31 LVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQ-YDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAES 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 45552053 110 LQIKG 114
Cdd:cd18315  81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  31 LVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQ-YDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAES 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 45552053 110 LQIKG 114
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053     33 DCTLAAEGKFLKAHKVVLSACSPYFATLLQEQ--YDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 45552053    111 QIKGLSD 117
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  31 LVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQ-YDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAES 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 45552053 110 LQIKG 114
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053     33 DCTLAAEGKFLKAHKVVLSACSPYFATLLQEQ--YDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 45552053    111 QIKGLSD 117
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  14 HQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATL----LQEQYDKHpiFILKDVKYQELRAMMDYMY 89
Cdd:cd18235   4 HTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMftgdLSESRANR--VTLQDVDGKALLLLIDYVY 81

                        90       100
                ....*....|....*....|...
gi 45552053  90 RGEVNISQDQLAALLKAAESLQI 112
Cdd:cd18235  82 TAEIQVTEENVQVLLPAANLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  33 DCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHP---IFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAES 109
Cdd:cd18293  17 DVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGqkvVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAARR 96

                        90       100
                ....*....|....*....|
gi 45552053 110 LQIKGLSDNRTGGGVAPKPE 129
Cdd:cd18293  97 LQISELESLCLEGGKLVKAP 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  12 NNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYF-ATLLQEQYDKHPIFI-LKDVKYQELRAMMDYMY 89
Cdd:cd18242   2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFcAMFTSEMSEKGKSEVeLQGLTASTMEILLDFVY 81

                        90       100
                ....*....|....*....|....*...
gi 45552053  90 RGEVNISQDQLAALLKAAESLQIKGLSD 117
Cdd:cd18242  82 TETVHVTVENVQELLPAACLLQLKGVKQ 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  14 HQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQY--DKHPIFILKDVKYQELRAMMDYMYRG 91
Cdd:cd18237   4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMteSKSSEVELKDAEPDIIELLVEFAYTA 83

                        90       100
                ....*....|....*....|.
gi 45552053  92 EVNISQDQLAALLKAAESLQI 112
Cdd:cd18237  84 RISVNSNNVQSLLDAANQYQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  14 HQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLL--------QEQYDkhpifiLKDVKYQELRAMM 85
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFtgnlsekeNSEVE------FQCIDETALQAIV 74

                        90       100
                ....*....|....*....|....*...
gi 45552053  86 DYMYRGEVNISQDQLAALLKAAESLQIK 113
Cdd:cd18257  75 EYAYTGTVFISQATVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053   3 DDQQFCLrwNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATL----LQEQYDKHpiFILKDVKY 78
Cdd:cd18259   6 DDLDFCL--PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMftgdFVESISAR--VEIKDVDP 81

                        90       100       110
                ....*....|....*....|....*....|...
gi 45552053  79 QELRAMMDYMYRGEVNISQDQLAALLKAAESLQ 111
Cdd:cd18259  82 AVMESLIDFAYTGKLTINQGNVEALIRTSNRLQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  14 HQSTLIS-VFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFAT--LLQEQYDKHPIFILKDVKYQELRAMMDYMYR 90
Cdd:cd18269   9 YQQTLLQdGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAmfLSDLEESKKKEVVLEDVDPDVMGMILKYLYT 88

                        90       100
                ....*....|....*....|..
gi 45552053  91 GEVNISQDQLAALLKAAESLQI 112
Cdd:cd18269  89 SEIDLNDQNVQDIFALASRFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  31 LVDCTLAAEGKFLKAHKVVLSACSPY----FATLLQEQYDKHpiFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKA 106
Cdd:cd18246  39 LCDIVLHVGTKEIKAHKVVLASCSPYfhamFTNEMSESRQTH--VTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPA 116

                        90
                ....*....|.
gi 45552053 107 AESLQIKGLSD 117
Cdd:cd18246 117 ASLLQLNGVRD 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  14 HQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATL----LQEQydKHPIFILKDVKYQELRAMMDYMY 89
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMftggMRES--SQDEIELKGVSAKGLKHILDFAY 78

                        90       100
                ....*....|....*....|...
gi 45552053  90 RGEVNISQDQLAALLKAAESLQI 112
Cdd:cd18255  79 TSELTLDLDCIQDVLGAAVHLQM 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  31 LVDCTLAAEGKFLKAHKVVLSACSPYFATLLQE-QYDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAES 109
Cdd:cd18233  18 LCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNsSSQKNDVFHLDIKNVGGIGQILDFMYTSHLDLNQDNVQVMLDIAQC 97

                ....
gi 45552053 110 LQIK 113
Cdd:cd18233  98 LQVQ 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  14 HQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYF-----ATLLQEQYDKhpiFILKDVKYQELRAMMDYM 88
Cdd:cd18250   4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFramfaGELRESRADR---VVLHGVSAEILGLLLDFS 80

                        90       100
                ....*....|....*....|...
gi 45552053  89 YRGEVNISQDQLAALLKAAESLQ 111
Cdd:cd18250  81 YTGRVTVTQDNVEALLRAADLFQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  20 SVFDTLLENET---LVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKhpIFILKDVKYQELRAMMDYMYRGEVNIS 96
Cdd:cd18208  11 SVLETLNEQRNrghFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD--IEIPSVVSVQSVQKLIDFMYSGVLRVS 88

                        90       100
                ....*....|....*....|....
gi 45552053  97 QDQLAALLKAAESLQIKGLSDNRT 120
Cdd:cd18208  89 QSEALQILTAASILQIKTVIDECT 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  25 LLENETLVDCTLAAEGKFLKAHKVVLSACSPYF-ATLLQ--EQYDKHPIfILKDVKYQELRAMMDYMYRGEVNISQDQLA 101
Cdd:cd18340  21 LLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFrAMFLSdlEESKKREI-VLEDVDPDVMGKILHYIYTSEIEITEQNVQ 99

                        90
                ....*....|.
gi 45552053 102 ALLKAAESLQI 112
Cdd:cd18340 100 DIFAAANMFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053   9 LRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYD-KHPIFILKDVKYQELRAMMDY 87
Cdd:cd18212   1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEvGQSIYMLEGMVAETFGALLEF 80

                        90       100
                ....*....|....*....|....*...
gi 45552053  88 MYRGEVNISQDQLAALLKAAESLQIKGL 115
Cdd:cd18212  81 IYTGCLQVGEKSLEQILATAQFLKVNDL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  20 SVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATL----LQEQYDKhpIFILKDVKYQELRAMMDYMYRGEVNI 95
Cdd:cd18272  21 SIMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMftsnLKEARNR--VIELKDVSESVFQLLVDYIYHGTVKL 98

                        90       100
                ....*....|....*....|
gi 45552053  96 SQDQLAALLKAAESLQIKGL 115
Cdd:cd18272  99 RVEELQETYEVADMYQLTAL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  14 HQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYdKHPIFILKDVKYQE---LRAMMDYMYR 90
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQL-KNNVSVINLDPEIEpegFRILLDFMYT 80

                        90       100
                ....*....|....*....|....*..
gi 45552053  91 GEVNISQDQLAALLKAAESLQIKGLSD 117
Cdd:cd18215  81 SRLNLREGNIMAVMATAMYLQMEHVVD 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  33 DCTLAAEGKFLKAHKVVLSACSPYFATLLQEQydkhpIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQI 112
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRD-----ILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQM 80

                ..
gi 45552053 113 KG 114
Cdd:cd18275  81 PC 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  14 HQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQyDKHPIFIL---KDVKYQELRAMMDYMYR 90
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGR-VGEGVSVLtlpSGLEARGFQLLLDFMYT 80

                        90       100
                ....*....|....*....|....*..
gi 45552053  91 GEVNISQDQLAALLKAAESLQIKGLSD 117
Cdd:cd18332  81 SRLPLTPRTVPAVLAAATYLQMEHVVE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  13 NHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQE--QYDKHPIFILKDVKYQELRAMMDYMYR 90
Cdd:cd18326   7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSgaVVDQQNVYEIDFVSAEALTALLDFAYT 86

                        90       100
                ....*....|....*....|....*..
gi 45552053  91 GEVNISQDQLAALLKAAESLQIKGLSD 117
Cdd:cd18326  87 ATLTVSTSNVGDILSAARLLEIPAVSH 113

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  25 LLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYD-------KHPIfilkdVKYQELRAMMDYMYRGEVNISQ 97
Cdd:cd18295  13 LLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKdkreinlKHPL-----VNPDAFRALLQYLYTGRLEIHV 87

                        90
                ....*....|....*...
gi 45552053  98 DQLAALLKAAESLQIKGL 115
Cdd:cd18295  88 DDVEDCKRLAKQCRLEEL 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  14 HQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHpIFILKDVKYQELRAMMDYMYRGEV 93
Cdd:cd18260   1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQ-RVELNDISPLGLATVITYAYTGKL 79

                        90       100
                ....*....|....*....|..
gi 45552053  94 NISQDQLAALLKAAESLQIKGL 115
Cdd:cd18260  80 TLSLYTIGSTISAASYLQIHAL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  16 STLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPY--FATLLQEQydkhpIFILKDVKYQELRAMMDYMYRGEV 93
Cdd:cd18303   3 SRLLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKwsNENLASTN-----ELDLSDISYEVVLALLRWLYTDEL 77

                        90       100
                ....*....|....*....|....*
gi 45552053  94 NISQDQ--LAALLKAAESLQIKGLS 116
Cdd:cd18303  78 DLTLDDefLLELMKAAKRFQLTDLV 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  14 HQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQE--QYDKHPIFILKDVKYQE-LRAMMDYMYR 90
Cdd:cd18329   4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQnaKETGQPTVATFDVFSPDtFTIILDFVYS 83

                        90       100
                ....*....|....*....|..
gi 45552053  91 GEVNISQDQLAALLKAAESLQI 112
Cdd:cd18329  84 GKLSLTSQNVIEVMSAASYLQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  25 LLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHPIFI-LKDVKYQELRAMMDYMYRG---EVNISQDQL 100
Cdd:cd18351  18 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIeISYVKYHIFQLVMQYLYCGgteSLLIKNNEI 97

                        90
                ....*....|....*
gi 45552053 101 AALLKAAESLQIKGL 115
Cdd:cd18351  98 MELLSAAKFFQLEAL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  13 NHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATL---LQEQYDKHPIFILKDVKYQELRAMMDYMY 89
Cdd:cd18230   3 SHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLycqVQKTSDQATVTHLDIVTAQGFKAIIDFMY 82

                        90       100
                ....*....|....*....|...
gi 45552053  90 RGEVNISQDQLAALLKAAESLQI 112
Cdd:cd18230  83 SAHLALTSKNVIEVMSAASYLQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552053  10 RWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATL----LQEQYDKHpiFILKDVKYQELRAMM 85
Cdd:cd18266   4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMftigMREAHQKE--VELVGASYIGLKAVI 81