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Hr78 Hormone-receptor-like in 78 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40378, updated on 9-Dec-2024

Summary

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Official Symbol
Hr78provided by FlyBase
Official Full Name
Hormone-receptor-like in 78provided by FlyBase
Primary source
FLYBASE:FBgn0015239
Locus tag
Dmel_CG7199
See related
AllianceGenome:FB:FBgn0015239
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7199; Dhr78; DHR78; Dmel\CG7199; HR78; Hr78D; NR2D1; XR78E/F
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in liquid clearance, open tracheal system and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including clypeo-labral primordium; embryonic epipharynx; embryonic hypopharynx; embryonic/larval midgut primordium; and gut section. Orthologous to several human genes including NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Hr78 in Genome Data Viewer
Location:
78D4-78D4; 3-47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21494019..21497494, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21487119..21490594, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43933 Neighboring gene Golgi complex-localized glycoprotein 1 Neighboring gene Esterase Q Neighboring gene M6 Neighboring gene Sak kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adult functions for the Drosophila DHR78 nuclear receptor. Marxreiter S, et al. Dev Dyn, 2018 Feb. PMID 29171103, Free PMC Article
  2. Essential roles for the Dhr78 orphan nuclear receptor during molting of the Drosophila tracheal system. Astle J, et al. Insect Biochem Mol Biol, 2003 Dec. PMID 14599492
  3. Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. Zelhof AC, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479823, Free PMC Article
  4. Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids. Baker KD, et al. Insect Biochem Mol Biol, 2000 Nov. PMID 10989290
  5. Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. Baker KD, et al. Genes Dev, 2007 Feb 15. PMID 17322404, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-negative bacterium HMP PubMed 
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of innate immune response HMP PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Hormone-receptor-like in 78
Names
CG7199-PA
CG7199-PB
CG7199-PC
CG7199-PD
CG7199-PE
CG7199-PF
Hr78-PA
Hr78-PB
Hr78-PC
Hr78-PD
Hr78-PE
Hr78-PF
X receptor at 78E/F

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21494019..21497494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079479.5 → NP_524203.2  Hormone-receptor-like in 78, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524203.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9ZJM0
    Related
    FBpp0078046
    Conserved Domains (2) summary
    cd06952
    Location:370 → 593
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cl02596
    Location:47 → 131
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  2. NM_206415.3 → NP_996137.1  Hormone-receptor-like in 78, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996137.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V288, Q24108, Q24142, Q8IPT4, Q9VP28
    UniProtKB/TrEMBL
    H9ZJM0, M9MS41
    Conserved Domains (2) summary
    cd06952
    Location:372 → 595
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:47 → 133
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  3. NM_001202222.1 → NP_001189151.1  Hormone-receptor-like in 78, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V288, Q24108, Q24142, Q8IPT4, Q9VP28
    UniProtKB/TrEMBL
    H9ZJM0, M9MS41
    Conserved Domains (2) summary
    cd06952
    Location:372 → 595
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:47 → 133
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  4. NM_001202223.1 → NP_001189152.1  Hormone-receptor-like in 78, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189152.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V288, Q24108, Q24142, Q8IPT4, Q9VP28
    UniProtKB/TrEMBL
    H9ZJM0, M9MS41
    Conserved Domains (2) summary
    cd06952
    Location:372 → 595
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:47 → 133
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  5. NM_168907.3 → NP_730636.1  Hormone-receptor-like in 78, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730636.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V288, Q24108, Q24142, Q8IPT4, Q9VP28
    UniProtKB/TrEMBL
    H9ZJM0, M9MS41
    Related
    FBpp0078044
    Conserved Domains (2) summary
    cd06952
    Location:372 → 595
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:47 → 133
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  6. NM_168908.3 → NP_730637.1  Hormone-receptor-like in 78, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730637.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V288, Q24108, Q24142, Q8IPT4, Q9VP28
    UniProtKB/TrEMBL
    H9ZJM0, M9MS41
    Related
    FBpp0078045
    Conserved Domains (2) summary
    cd06952
    Location:372 → 595
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:47 → 133
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MS41 M9MS41
Q24142.2 Q24142

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