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    bs blistered [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37890, updated on 17-Dec-2024

    Summary

    Official Symbol
    bsprovided by FlyBase
    Official Full Name
    blisteredprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004101
    Locus tag
    Dmel_CG3411
    See related
    AllianceGenome:FB:FBgn0004101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ba; Bs; BS; bs/Dsrf; bs/DSRF; CG3411; D-SRF; Dmel\CG3411; DmSRF; Drf; dsrf; dSRF; DSrf; DSRF; DSrf/bs; Group IIc; l(2)03267; Mal; pruned/DSRF; px; Serf; srf; Srf; SRF
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and DNA-binding transcription factor binding activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including instar larval or pupal development; short-term memory; and terminal branching, open tracheal system. Located in nucleus. Is expressed in several structures, including gut section; larval muscle cell; organism subdivision; presumptive embryonic/larval central nervous system; and wing vein. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    60C6-60C7; 2-106 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24342861..24376473)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20230384..20263996)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44282 Neighboring gene slow border cells Neighboring gene blistered anti-sense lncRNA Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Asparagine-GTT 1-9 Neighboring gene uncharacterized protein Neighboring gene muscarinic Acetylcholine Receptor, A-type Neighboring gene long non-coding RNA:CR44813

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    mobile_element

    • Loc: 24353484-24361787 mobile_element_type = transposon:roo{}883

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces PubMed 
    involved_in branching involved in open tracheal system development PubMed 
    involved_in cell differentiation PubMed 
    involved_in imaginal disc-derived wing morphogenesis PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis PubMed 
    involved_in instar larval development PubMed 
    involved_in open tracheal system development PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in pupal development PubMed 
    involved_in short-term memory PubMed 
    involved_in sleep PubMed 
    involved_in terminal branching, open tracheal system PubMed 
    involved_in wing disc development PubMed 
    Component Evidence Code Pubs
    located_in nucleus PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    blistered
    Names
    CG3411-PA
    CG3411-PB
    CG3411-PC
    SRF
    balloon
    blistered/DSRF
    blistered/Drosophila serum response factor
    bs-PA
    bs-PB
    bs-PC
    drosophila serum response
    drosophila serum response factor
    factor
    pruned
    serum response factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24342861..24376473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299908.1 → NP_001286837.1  blistered, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286837.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24535, Q9W182
      UniProtKB/TrEMBL
      A0A0B4LGL8
      Conserved Domains (1) summary
      cd00266
      Location:166 → 247
      MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...
    2. NM_001144279.3 → NP_001137751.1  blistered, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137751.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZQ0
      Conserved Domains (1) summary
      cd00266
      Location:166 → 247
      MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...
    3. NM_166667.3 → NP_726438.1  blistered, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726438.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24535, Q9W182
      UniProtKB/TrEMBL
      A0A0B4LGL8
      Related
      FBpp0072178
      Conserved Domains (1) summary
      cd00266
      Location:166 → 247
      MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...
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