Snr1 Snf5-related 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Snr1provided by FlyBase
Official Full Name: Snf5-related 1provided by FlyBase
Primary source: FLYBASE:FBgn0011715
Locus tag: Dmel_CG1064
See related: AllianceGenome:FB:FBgn0011715
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BAP45; CG1064; Dmel\CG1064; l(3)01319; snr; Snr; snr-1; Snr-1; snr1; SNR1; Snr1/BAP45
Summary: Enables SET domain binding activity and Tat protein binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; negative regulation of neuroblast proliferation; and regulation of DNA-templated transcription. Located in nucleus. Part of brahma complex. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; imaginal disc; and mesoderm. Used to study Coffin-Siris syndrome 3; atypical teratoid rhabdoid tumor; and rhabdoid cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; central nervous system cancer (multiple); rhabdoid cancer; and schwannomatosis (multiple). Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 83A4-83A4; 3-47.5 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5470926..5472754)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1296648..1298476)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A chromatin remodelling SWI/SNF subunit, Snr1, regulates neural stem cell determination and differentiation.
Title: A chromatin remodelling SWI/SNF subunit, Snr1, regulates neural stem cell determination and differentiation.
Knockdown of Snr1, the fly orthologue of SMARCB1, resulted in a lethal phenotype and epigenetic alterations in the fly model of SMARCB1 deficiency.
Title: Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors.
the cytoplasmic Snr1 may play a tumor suppressive role in Drosophila imaginal tissues.
Title: The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in Drosophila Imaginal Tissues.
our results support the view that SNR1, and specifically the repeat 2 region, has a critical role in mediating cell growth control functions of the metazoan SWI/SNF complexes.
Title: The Drosophila SNR1 (SNF5/INI1) subunit directs essential developmental functions of the Brahma chromatin remodeling complex.
Mutations in genes encoding other Brm complex components, including snr1 (BAP45), osa and deficiencies that remove BAP60 and BAP111 can also suppress the DmcycE(JP) eye phenotype.
Title: Drosophila cyclin E interacts with components of the Brahma complex.
This is the first instance of phosphorylation of SNR1 or any of its homologues and implicates the DYRK family of kinases with a role in chromatin remodelling.
Title: dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX.
SNR1 helps mediate associations between the Brm complex and DmcycE/CDK2 both in vitro and in vivo.
Title: SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.
SNR1 is essential for some, but not all Brm functions, and it likely serves as an optional subunit, directing Brm complex activity to specific gene loci or cellular processes.
Title: SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SET domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables Tat protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell dedifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in dendrite guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of brahma complex	IBA Inferred from Biological aspect of Ancestor more info
part_of brahma complex	IDA Inferred from Direct Assay more info	PubMed
part_of nBAF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of npBAF complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Snf5-related 1

Names: CG1064-PA; Snr1-PA; snf-related1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

5470926..5472754

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169055.3 → NP_730935.1 Snf5-related 1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730935.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24090

Related

FBpp0078331

Conserved Domains (2) summary

pfam04855
Location:165 → 348

SNF5; SNF5 / SMARCB1 / INI1

cd21086
Location:5 → 92

WH_NTD_SMARCB1; N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) and similar proteins