ash2 absent, small, or homeotic discs 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ash2provided by FlyBase
Official Full Name: absent, small, or homeotic discs 2provided by FlyBase
Primary source: FLYBASE:FBgn0000139
Locus tag: Dmel_CG6677
See related: AllianceGenome:FB:FBgn0000139
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1124/11; 291.8; 703; ash-2; Ash2; ASH2; Ash2L; CG6677; Dmel\CG6677; l(3)112411; l(3)S112411; l(3)SG65; mad
Summary: Enables DNA binding activity; enzyme binding activity; and transcription coactivator activity. Involved in several processes, including dendrite morphogenesis; instar larval or pupal development; and regulation of gene expression. Located in nucleus and polytene chromosome puff. Part of MLL1/2 complex; MLL3/4 complex; and Set1C/COMPASS complex. Is expressed in embryonic/larval fat body; embryonic/larval salivary gland; imaginal disc; and organism. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 96A13-96A13; 3-85 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24650125..24653376)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20475847..20479098)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ash2 functions together with Trr as an ecdysone receptor coactivator.
Title: Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr.
the gene is involved in Drosophila wing development
Title: The ash2 gene is involved in Drosophila wing development.
Provides a molecular framework for a mechanism required to maintain cellular identities in wing development.
Title: Activation and repression activities of ash2 in Drosophila wing imaginal discs.
ASH2 maintains active transcription by binding a producer of nuclear phosphoinositides and downregulating histone H1 hyperphosphorylation.
Title: The direct interaction between ASH2, a Drosophila trithorax group protein, and SKTL, a nuclear phosphatidylinositol 4-phosphate 5-kinase, implies a role for phosphatidylinositol 4,5-bisphosphate in maintaining transcriptionally active chromatin.
transcriptional network controlled by the trithorax-group gene ash2
Title: Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc development	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in instar larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupal development	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ecdysone	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MLL1/2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of MLL3/4 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Set1C/COMPASS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set1C/COMPASS complex	IDA Inferred from Direct Assay more info	PubMed
part_of Set1C/COMPASS complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: absent, small, or homeotic discs 2

Names: Absent, small or homeotic disc 2; CG6677-PB; CG6677-PC; CG6677-PE; absent small or homeotic discs 2; absent, small or homeotic discs 2; ash2-PB; ash2-PC; ash2-PE; many abnormal discs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24650125..24653376

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176558.3 → NP_788735.1 absent, small, or homeotic discs 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788735.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DMU8, Q8IMW1, Q94545, Q960W8

Related

FBpp0084040

Conserved Domains (2) summary

cd15583
Location:36 → 87

PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins

cd12872
Location:320 → 510

SPRY_Ash2; SPRY domain in Ash2
NM_001260363.1 → NP_001247292.1 absent, small, or homeotic discs 2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247292.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7H6

Conserved Domains (1) summary

cd12872
Location:1 → 174

SPRY_Ash2; SPRY domain in Ash2
NM_170160.2 → NP_733024.1 absent, small, or homeotic discs 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733024.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94545

Related

FBpp0084039

Conserved Domains (1) summary

cd12872
Location:114 → 304

SPRY_Ash2; SPRY domain in Ash2