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br broad [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44505, updated on 9-Dec-2024

Summary

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Official Symbol
brprovided by FlyBase
Official Full Name
broadprovided by FlyBase
Primary source
FLYBASE:FBgn0283451
Locus tag
Dmel_CG11491
See related
AllianceGenome:FB:FBgn0283451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2B5; 2Bc; A18; Br; BR; br-c; br-C; Br-c; Br-C; BR-c; BR-C; BR-C Z1; Br-C Z2; Br-C-Z3; br-Z1; BR-Z1; br-Z2; BR-Z2; br-Z3; BR-Z3; br-Z4; Br-Z4; BR-Z4; BrC; BRC; BrC-Z1; BRC-Z1; BRC-Z2; BRC-Z3; BRC-Z4; Broad; BrZ3; BR_C; CG11491; CG11509; CG11511; CG11514; de12; Dmel\CG11491; ecs; EG:123F11.1; EG:17A9.1; EG:25D2.1; l(1)2Ba; l(1)2Bab; l(1)2Bad; l(1)2Bb; l(1)2Bc; l(1)2Bd; l(1)d norm-12; l(1)d.norm.1; l(1)dn1; l(1)ESHS5; l(1)G0018; l(1)G0042; l(1)G0284; l(1)G0284a; l(1)G0318; l(1)G0401; l(1)n34; l(1)npr-1; l(1)npr1; l(1)pp-1; l(1)pp-2; l(1)pp1; l(1)PP1; l(1)pp2; l(1)ts132; l(1)ts144; l(1)ts358; l(1)ts376; npr; npr-1; npr1; nprl; nrp; nrp1; o.c.c.; PP1; PP2; rbp; rdp; rds; uq; Z1; Z2; Z3; Z4
Old locus tag
Dmel_CG11509
Summary
Enables DNA-binding transcription repressor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including compound eye morphogenesis; dorsal appendage formation; and regulation of gene expression. Located in neuronal cell body; nucleus; and polytene chromosome. Is expressed in several structures, including anterior-posterior subdivision of organism; brain; follicle cell; gland; and thoracic neuromere. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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Location:
2B3-2B5; 1-0.2 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1575132..1664869)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1469165..1558902)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene insomniac Neighboring gene uncharacterized protein Neighboring gene Mucin related 2B Neighboring gene small non-coding RNA 400 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene deep orange Neighboring gene halfway

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Imaginal disc development in a non-pupariating lethal mutant inDrosophila melanogaster. Fristrom DK, et al. Wilehm Roux Arch Dev Biol, 1981 Jan. PMID 28305365
  2. Differential expression of Broad-Complex transcription factors may forecast tissue-specific developmental fates during Drosophila metamorphosis. Emery IF, et al. Development, 1994 Nov. PMID 7720567
  3. Enhancer-trap targeting at the Broad-Complex locus of Drosophila melanogaster. Gonzy-Tréboul G, et al. Genes Dev, 1995 May 1. PMID 7744254
  4. Cytogenetic analysis of the 2B3-4--2B11 region of the X chromosome of Drosophila melanogaster. III. Puffing disturbance in salivary gland chromosomes of homozygotes for mutation l(1)pp1t10. Zhimulev IF, et al. Chromosoma, 1982. PMID 6813059
  5. [Cloning the BR-C gene in Drosophila virilis]. Doronkin SG, et al. Genetika, 1998 Apr. PMID 9612700

See all (576) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development.
    Title: The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development.
  2. let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State.
    Title: let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State.
  3. Broad as an important cell-intrinsic transcription factor that promotes the neuroepithelial-cell-to-neuroblast transition.
    Title: Broad Promotes Neuroepithelial Stem Cell Differentiation in the Drosophila Optic Lobe.
  4. Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors Chinmo and Broad.
    Title: Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors.
  5. Polytene chromosome stains showed that Cg co-localizes with EcR, the major regulator of BR-C, at the BR-C locus and that EcR binding to chromatin was sensitive to changes in Cg levels
    Title: Combgap Promotes Ovarian Niche Development and Chromatin Association of EcR-Binding Regions in BR-C.
  6. The CSN suppresses Sens through repression of the ecdysone signaling target gene broad (br) that encodes the BR-Z1 transcription factor to activate sens expression
    Title: The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence.
  7. Early gene Broad complex(BR-C) could be regulating the immune pathways by activating Relish and physically interacting with it to activate antimicrobial peptides expression.
    Title: Early gene Broad complex plays a key role in regulating the immune response triggered by ecdysone in the Malpighian tubules of Drosophila melanogaster.
  8. broad (br), encoding a small group of zinc-finger transcription factors resulting from alternative splicing, is a transcriptional target of Notch nuclear effector Suppressor of Hairless (Su(H)).
    Title: Regulation of broad by the Notch pathway affects timing of follicle cell development.
  9. Understanding Broad expression is impossible without simultaneously considering two enhancers, a dynamic gradient, and a network with extracellular and intracellular components.
    Title: Dynamic model for the coordination of two enhancers of broad by EGFR signaling.
  10. Broad (Br)-mediated hormone signaling regulates AMP specification
    Title: Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to ecdysone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to ecdysone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye photoreceptor fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eclosion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gravitaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in progression of morphogenetic furrow involved in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of development, heterochronic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ecdysone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to symbiont IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in salivary gland histolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
broad
Names
Br-C
CG11491-PA
CG11491-PB
CG11491-PC
CG11491-PE
CG11491-PG
CG11491-PH
CG11491-PI
CG11491-PJ
CG11491-PL
CG11491-PM
CG11491-PN
CG11491-PO
CG11491-PP
CG11491-PQ
CG11491-PR
CG11491-PS
br-PA
br-PB
br-PC
br-PE
br-PG
br-PH
br-PI
br-PJ
br-PL
br-PM
br-PN
br-PO
br-PP
br-PQ
br-PR
br-PS
broad complex
broad-complex
ecdysone-sensitivity
lethal(1)2Bab
lethal(1)2Bc
lethal(1)2Bd
lethal(1)discs normal
lethal(1)non-pupariating-1
non-pupariating
non-pupariating-1
overlapping-complementation-complex
reduced bristles on palps
reduced palps
unequal wings

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1575132..1664869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201598.1 → NP_001188527.1  broad, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188527.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46065, O46066, Q01293, Q01295, Q01296, Q9W571, Q9W574
    UniProtKB/TrEMBL
    M9MSM6
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:635 → 662
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  2. NM_001258533.1 → NP_001245462.1  broad, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245462.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46065, O46066, Q01293, Q01295, Q01296, Q9W571, Q9W574
    UniProtKB/TrEMBL
    D8FT05
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:574 → 601
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  3. NM_001144672.3 → NP_001138144.1  broad, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138144.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46064, Q24206, Q9W575
    UniProtKB/TrEMBL
    A4V3U8, Q9W572
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:712 → 729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  4. NM_166897.2 → NP_726753.1  broad, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726753.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46064, Q24206, Q9W575
    UniProtKB/TrEMBL
    A4V3U8, Q9W572
    Related
    FBpp0070251
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:712 → 729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  5. NM_001169167.2 → NP_001162638.2  broad, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162638.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJB2
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:712 → 729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  6. NM_001201596.3 → NP_001188525.1  broad, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188525.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRX4
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:441 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  7. NM_166894.4 → NP_726750.1  broad, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726750.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6G6CYY5
    Related
    FBpp0070255
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:589 → 610
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  8. NM_166893.3 → NP_726749.2  broad, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726749.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRX4
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:441 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  9. NM_001382013.1 → NP_001368968.1  broad, isoform R [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H2EEH5
    Conserved Domains (2) summary
    sd00017
    Location:441 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:31 → 114
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

  10. NM_166896.3 → NP_726752.1  broad, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726752.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46064, Q24206, Q9W575
    UniProtKB/TrEMBL
    A4V3U8, Q9W572
    Related
    FBpp0070253
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:712 → 729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  11. NM_001272205.1 → NP_001259134.1  broad, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259134.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46064, Q24206, Q9W575
    UniProtKB/TrEMBL
    A4V3U8, Q9W572
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:712 → 729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  12. NM_080020.4 → NP_524759.2  broad, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524759.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46065, O46066, Q01293, Q01295, Q01296, Q9W571, Q9W574
    UniProtKB/TrEMBL
    M9MSM6
    Related
    FBpp0070252
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:635 → 662
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  13. NM_166898.2 → NP_726754.1  broad, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726754.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46065, O46066, Q01293, Q01295, Q01296, Q9W571, Q9W574
    UniProtKB/TrEMBL
    D8FT05
    Related
    FBpp0070256
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:574 → 601
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  14. NM_166895.2 → NP_726751.2  broad, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726751.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46064, Q24206, Q9W575
    UniProtKB/TrEMBL
    A4V3U8, Q9W572
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:712 → 729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain

  15. NM_001414056.1 → NP_001401048.1  broad, isoform S [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6G6CYY5

  16. NM_001201597.1 → NP_001188526.1  broad, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188526.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46065, O46066, Q01293, Q01295, Q01296, Q9W571, Q9W574
    UniProtKB/TrEMBL
    M9MSM6
    Conserved Domains (3) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:635 → 662
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6H2EEH5 A0A6H2EEH5
D8FT05 D8FT05
E1JJB2 E1JJB2
M9MSM6 M9MSM6
Q01295.2 Q01295
Q24206.2 Q24206
Q7K2S6 Q7K2S6
Q8IRX4 Q8IRX4
Q9W572 Q9W572

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