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Srrm1 serine and arginine repetitive matrix 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313620, updated on 4-Jan-2025

Summary

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Official Symbol
Srrm1provided by RGD
Official Full Name
serine and arginine repetitive matrix 1provided by RGD
Primary source
RGD:1311258
See related
EnsemblRapid:ENSRNOG00000018194 AllianceGenome:RGD:1311258
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in regulation of mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human SRRM1 (serine and arginine repetitive matrix 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 156.6), Thymus (RPKM 151.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Srrm1 in Genome Data Viewer
Location:
5q36
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (152843167..152875554, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (147559515..147591895, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (153675619..153708187, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel 4 Neighboring gene uncharacterized LOC134479039 Neighboring gene uncharacterized LOC120103007 Neighboring gene noncompact myelin associated protein Neighboring gene uncharacterized LOC134487010 Neighboring gene RCAN family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A preliminary investigation on placenta protein profile reveals only modest changes in well controlled gestational diabetes mellitus. Lapolla A, et al. Eur J Mass Spectrom (Chichester), 2013. PMID 24308201
  2. The ever-increasing complexities of the exon junction complex. Tange TØ, et al. Curr Opin Cell Biol, 2004 Jun. PMID 15145352
  3. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, et al. Nucleic Acids Res, 2007. PMID 17537823, Free PMC Article
  4. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
  5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/arginine repetitive matrix protein 1
Names
serine/arginine repetitive matrix 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107986.2 → NP_001101456.2  serine/arginine repetitive matrix protein 1

    See identical proteins and their annotated locations for NP_001101456.2

    Status: PROVISIONAL

    Source sequence(s)
    BC166715
    UniProtKB/TrEMBL
    A0A8I6ATQ3, B2RYB3
    Related
    ENSRNOP00000073024.3, ENSRNOT00000082037.3
    Conserved Domains (2) summary
    pfam00906
    Location:611 → 702
    Hepatitis_core; Hepatitis core antigen
    pfam01480
    Location:46 → 115
    PWI; PWI domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    152843167..152875554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110051.2 → XP_038965979.1  serine/arginine repetitive matrix protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6ATQ3
    Conserved Domains (3) summary
    PHA03307
    Location:399 → 734
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK12323
    Location:601 → 796
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  2. XM_039110050.2 → XP_038965978.1  serine/arginine repetitive matrix protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6ATQ3
    Conserved Domains (3) summary
    PHA03247
    Location:377 → 725
    PHA03247; large tegument protein UL36; Provisional
    PRK12323
    Location:602 → 797
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  3. XM_063287766.1 → XP_063143836.1  serine/arginine repetitive matrix protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ATQ3
    Related
    ENSRNOP00000082336.2, ENSRNOT00000119442.2

  4. XM_006239184.5 → XP_006239246.1  serine/arginine repetitive matrix protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ATQ3
    Conserved Domains (2) summary
    pfam00906
    Location:617 → 708
    Hepatitis_core; Hepatitis core antigen
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  5. XM_006239185.5 → XP_006239247.1  serine/arginine repetitive matrix protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ATQ3, F7FND9
    Related
    ENSRNOP00000097970.2, ENSRNOT00000096755.2
    Conserved Domains (2) summary
    pfam00906
    Location:610 → 701
    Hepatitis_core; Hepatitis core antigen
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  6. XM_006239183.5 → XP_006239245.1  serine/arginine repetitive matrix protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ATQ3
    Conserved Domains (2) summary
    pfam00906
    Location:624 → 715
    Hepatitis_core; Hepatitis core antigen
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  7. XM_006239182.5 → XP_006239244.1  serine/arginine repetitive matrix protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZV38, A0A8I6ATQ3
    Related
    ENSRNOP00000052955.4, ENSRNOT00000056105.5
    Conserved Domains (2) summary
    pfam00906
    Location:625 → 716
    Hepatitis_core; Hepatitis core antigen
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  8. XM_063287769.1 → XP_063143839.1  serine/arginine repetitive matrix protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A8I6ATQ3

  9. XM_063287768.1 → XP_063143838.1  serine/arginine repetitive matrix protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A8I6ATQ3

  10. XM_039110052.2 → XP_038965980.1  serine/arginine repetitive matrix protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I6ATQ3
    Conserved Domains (3) summary
    PHA03247
    Location:347 → 703
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:580 → 776
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  11. XM_063287767.1 → XP_063143837.1  serine/arginine repetitive matrix protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8I6ATQ3

  12. XM_017593406.3 → XP_017448895.1  serine/arginine repetitive matrix protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6ATQ3

  13. XM_063287770.1 → XP_063143840.1  serine/arginine repetitive matrix protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A8I6ATQ3

  14. XM_008764242.4 → XP_008762464.1  serine/arginine repetitive matrix protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I6ATQ3
    Conserved Domains (2) summary
    pfam00906
    Location:586 → 677
    Hepatitis_core; Hepatitis core antigen
    pfam01480
    Location:7 → 76
    PWI; PWI domain

  15. XM_063287771.1 → XP_063143841.1  serine/arginine repetitive matrix protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A8I6ATQ3

  16. XM_063287772.1 → XP_063143842.1  serine/arginine repetitive matrix protein 1 isoform X16

    UniProtKB/TrEMBL
    A0A8I6ATQ3

  17. XM_017593407.3 → XP_017448896.1  serine/arginine repetitive matrix protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A8I6ATQ3
    Conserved Domains (2) summary
    PHA03247
    Location:306 → 734
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  18. XM_063287773.1 → XP_063143843.1  serine/arginine repetitive matrix protein 1 isoform X17

Nucleotide Protein Strain
Heading Accession and Version

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