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ERp60 Endoplasmic reticulum p60 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36270, updated on 4-Jan-2025

Summary

Official Symbol
ERp60provided by FlyBase
Official Full Name
Endoplasmic reticulum p60provided by FlyBase
Primary source
FLYBASE:FBgn0033663
Locus tag
Dmel_CG8983
See related
AllianceGenome:FB:FBgn0033663
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe3D9; CG8983; D-ERp60; dERp60; Dmel\CG8983; Erp60; Ov6
Summary
Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; amnioserosa primordium; epithelium; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See ERp60 in Genome Data Viewer
Location:
48C5-48C5; 2-65 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11887568..11890979, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7775073..7778484, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene cutoff Neighboring gene eukaryotic translation elongation factor 1 alpha 1 Neighboring gene Microcephalin Neighboring gene Zinc/iron regulated transporter-related protein 48C

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in protein folding  
involved_in response to endoplasmic reticulum stress  
Component Evidence Code Pubs
located_in endomembrane system PubMed 
is_active_in endoplasmic reticulum  

General protein information

Preferred Names
endoplasmic reticulum p60
Names
CG8983-PA
ERp60-PA
anon-fast-evolving-3D9
protein disulfide isomerase homolog
NP_725084.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11887568..11890979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165849.3 → NP_725084.2  endoplasmic reticulum p60 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725084.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3YMU0, Q9TWZ1
    Related
    FBpp0087164
    Conserved Domains (5) summary
    cd02995
    Location:365 → 467
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cd02997
    Location:23 → 126
    PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
    cd03069
    Location:133 → 235
    PDI_b_ERp57; PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b; ERp57 (or ERp60) exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting ...
    cd03073
    Location:239 → 345
    PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
    TIGR01130
    Location:23 → 479
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
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