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Nlp Nucleoplasmin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43560, updated on 4-Jan-2025

Summary

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Official Symbol
Nlpprovided by FlyBase
Official Full Name
Nucleoplasminprovided by FlyBase
Primary source
FLYBASE:FBgn0016685
Locus tag
Dmel_CG7917
See related
AllianceGenome:FB:FBgn0016685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7917; Crp1; CRP1; dCAF-4; Dmel\CG7917; dNLP; dNLP-S; nlp; NLP; p22
Summary
Enables histone binding activity. Involved in chromatin remodeling and sperm DNA decondensation. Located in cytoplasm and nucleolus. Colocalizes with polytene chromosome interband. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; and ganglia. Used to study primary ovarian insufficiency. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including NPM3 (nucleophosmin/nucleoplasmin 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Nlp in Genome Data Viewer
Location:
99D1-99D1; 3-100 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30004785..30010352)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25830507..25836074)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tace Neighboring gene Nucleophosmin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular and cellular characterization of CRP1, a Drosophila chromatin decondensation protein. Crevel G, et al. J Struct Biol, 1997 Feb. PMID 9087911
  2. The crystal structure of Drosophila NLP-core provides insight into pentamer formation and histone binding. Namboodiri VM, et al. Structure, 2003 Feb. PMID 12575937
  3. Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1. Xiao W, et al. Signal Transduct Target Ther, 2021 Apr 16. PMID 33859171, Free PMC Article
  4. Oligomerization of Drosophila Nucleoplasmin-Like Protein is required for its centromere localization. Anselm E, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30357352, Free PMC Article
  5. A simple and versatile system for the ATP-dependent assembly of chromatin. Khuong MT, et al. J Biol Chem, 2017 Nov 24. PMID 28982979, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.
    Title: Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.
  2. NLP and HMR largely co-localize in domains that are immediately adjacent to, yet distinct from centromere domains defined by the centromeric histone dCENP-A.
    Title: Oligomerization of Drosophila Nucleoplasmin-Like Protein is required for its centromere localization.
  3. NLP is essential for the positioning of centromeres during cell division in Drosophila.
    Title: The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sperm DNA decondensation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm HDA PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleoplasmin
Names
CG7917-PA
CG7917-PB
Nlp-PA
Nlp-PB
Nucleoplasmin-like
chromatin decondensation protein 1
nucleoplasmin-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30004785..30010352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079833.2 → NP_524557.1  nucleoplasmin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524557.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24565, Q27415, Q540W3, Q9VAC3
    UniProtKB/TrEMBL
    A0A0B4KI24
    Related
    FBpp0084918, FBtr0085552
    Conserved Domains (1) summary
    pfam03066
    Location:6 → 104
    Nucleoplasmin; Nucleoplasmin/nucleophosmin domain

  2. NM_001276165.1 → NP_001263094.1  nucleoplasmin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263094.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24565, Q27415, Q540W3, Q9VAC3
    UniProtKB/TrEMBL
    A0A0B4KI24
    Conserved Domains (1) summary
    pfam03066
    Location:6 → 104
    Nucleoplasmin; Nucleoplasmin/nucleophosmin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KI24 A0A0B4KI24
Q27415.1 Q27415

Gene LinkOut

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