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Ctps CTP synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39645, updated on 4-Jan-2025

Summary

Official Symbol
Ctpsprovided by FlyBase
Official Full Name
CTP synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0266452
Locus tag
Dmel_CG45070
See related
AllianceGenome:FB:FBgn0266452
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG45070; CG6854; CTP syn; ctps; CTPS; CTPsyn; CTPSyn; dCTPS; Dmel\CG45070
Old locus tag
Dmel_CG6854
Summary
Enables CTP synthase activity. Involved in CTP biosynthetic process and larval lymph gland hemopoiesis. Acts upstream of with a positive effect on phospholipid metabolic process. Located in cytoophidium and cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult brain cell body rind; brain; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1) and CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Ctps in Genome Data Viewer
Location:
71B4-71B5; 3-42 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15097914..15113003)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15091014..15106103)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Pericentrin-like protein Neighboring gene long non-coding RNA:CR43973 Neighboring gene stepping stone Neighboring gene Glycyl-tRNA synthetase Neighboring gene pseudo Neighboring gene antisense RNA:CR43971 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Centrosomal protein 135kDa Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables CTP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables CTP synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables CTP synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables CTP synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in CTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in CTP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in CTP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in CTP biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in larval lymph gland hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_positive_effect phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoophidium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoophidium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol HDA PubMed 

General protein information

Preferred Names
CTP synthase
Names
CG45070-PA
CG45070-PB
CG45070-PC
CTP synthetase
CTP-synthase
Ctps-PA
Ctps-PB
Ctps-PC
ctp synthase
cytidine synthase
NP_001287067.1
NP_648747.1
NP_730023.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15097914..15113003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300138.1NP_001287067.1  CTP synthase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287067.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUL0, Q9VUL1
    UniProtKB/TrEMBL
    X2JCY2
    Conserved Domains (1) summary
    PLN02327
    Location:1556
    PLN02327; CTP synthase
  2. NM_168606.2NP_730023.1  CTP synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730023.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUL0, Q9VUL1
    UniProtKB/TrEMBL
    X2JCY2
    Related
    FBpp0310803
    Conserved Domains (1) summary
    PLN02327
    Location:1556
    PLN02327; CTP synthase
  3. NM_140490.4NP_648747.1  CTP synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648747.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUL1
    Related
    FBpp0310804
    Conserved Domains (4) summary
    cd01746
    Location:295540
    GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
    pfam00117
    Location:308542
    GATase; Glutamine amidotransferase class-I
    pfam06418
    Location:53267
    CTP_synth_N; CTP synthase N-terminus
    cl23759
    Location:1453
    GT1; GT1, myb-like, SANT family