U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Endometrioid adenocarcinoma

MedGen UID:
293976
•Concept ID:
C1569637
•
Neoplastic Process
Synonyms: Adenocarcinoma, Endometrioid; Adenocarcinomas, Endometrioid; Endometrioid Adenocarcinoma; Endometrioid Adenocarcinomas
SNOMED CT: Endometrioid adenocarcinoma (30289006); Endometrioid cystadenocarcinoma (30289006)
 
Monarch Initiative: MONDO:0005026

Definition

An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Endometrioid adenocarcinoma

Professional guidelines

PubMed

Challenges and controversies in the conservative management of uterine and ovarian cancer.
Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603
Therapeutic options for management of endometrial hyperplasia.
Chandra V, Kim JJ, Benbrook DM, Dwivedi A, Rai R
J Gynecol Oncol 2016 Jan;27(1):e8. Epub 2015 Dec 1 doi: 10.3802/jgo.2016.27.e8. PMID: 26463434Free PMC Article
Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer, 2024

Recent clinical studies

Etiology

Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Endometrium and steroids, a pathologic overview.
Plaza-Parrochia F, Romero C, Valladares L, Vega M
Steroids 2017 Oct;126:85-91. Epub 2017 Aug 18 doi: 10.1016/j.steroids.2017.08.007. PMID: 28827068
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Endometrial hyperplasia.
Mills AM, Longacre TA
Semin Diagn Pathol 2010 Nov;27(4):199-214. doi: 10.1053/j.semdp.2010.09.002. PMID: 21309256

Diagnosis

Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Endometrium and steroids, a pathologic overview.
Plaza-Parrochia F, Romero C, Valladares L, Vega M
Steroids 2017 Oct;126:85-91. Epub 2017 Aug 18 doi: 10.1016/j.steroids.2017.08.007. PMID: 28827068
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Endometrial hyperplasia.
Mills AM, Longacre TA
Semin Diagn Pathol 2010 Nov;27(4):199-214. doi: 10.1053/j.semdp.2010.09.002. PMID: 21309256

Therapy

Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Clear cell carcinoma of the ovary: molecular insights and future therapeutic perspectives.
Mabuchi S, Sugiyama T, Kimura T
J Gynecol Oncol 2016 May;27(3):e31. doi: 10.3802/jgo.2016.27.e31. PMID: 27029752Free PMC Article
Endometrial cancer-targeted therapies myth or reality? Review of current targeted treatments.
Lheureux S, Oza AM
Eur J Cancer 2016 May;59:99-108. Epub 2016 Mar 25 doi: 10.1016/j.ejca.2016.02.016. PMID: 27017291
ARID1A gene mutation in ovarian and endometrial cancers (Review).
Takeda T, Banno K, Okawa R, Yanokura M, Iijima M, Irie-Kunitomi H, Nakamura K, Iida M, Adachi M, Umene K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D
Oncol Rep 2016 Feb;35(2):607-13. Epub 2015 Nov 16 doi: 10.3892/or.2015.4421. PMID: 26572704Free PMC Article
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523

Prognosis

Challenges and controversies in the conservative management of uterine and ovarian cancer.
Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Management and prognosis of endometrioid borderline tumors of the ovary.
Uzan C, Berretta R, Rolla M, Gouy S, Fauvet R, Darai E, Duvillard P, Morice P
Surg Oncol 2012 Sep;21(3):178-84. Epub 2012 Mar 13 doi: 10.1016/j.suronc.2012.02.002. PMID: 22418038
Endometrial cancer, types, prognosis, female hormones and antihormones.
Ulrich LS
Climacteric 2011 Aug;14(4):418-25. Epub 2011 Mar 22 doi: 10.3109/13697137.2010.550974. PMID: 21426234

Clinical prediction guides

Clinical and multiparametric MRI features for differentiating uterine carcinosarcoma from endometrioid adenocarcinoma.
Chen X, Guo Q, Chen X, Zheng W, Kang Y, Cao D
BMC Med Imaging 2024 Feb 19;24(1):48. doi: 10.1186/s12880-024-01225-4. PMID: 38373912Free PMC Article
Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Malignant Transformation of Vaginal Endometriosis - A Review of Literature.
Cozzolino M, Nasioudis D, Sisti G, Coccia ME
Gynecol Obstet Invest 2017;82(2):105-112. Epub 2016 Sep 13 doi: 10.1159/000449198. PMID: 27618565
Molecular Analysis of Mixed Endometrioid and Serous Adenocarcinoma of the Endometrium.
Lawrenson K, Pakzamir E, Liu B, Lee JM, Delgado MK, Duncan K, Gayther SA, Liu S, Roman L, Mhawech-Fauceglia P
PLoS One 2015;10(7):e0130909. Epub 2015 Jul 1 doi: 10.1371/journal.pone.0130909. PMID: 26132201Free PMC Article

Recent systematic reviews

Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Malignant transformation of abdominal wall endometriosis: A systematic review of the epidemiology, diagnosis, treatment, and outcomes.
Liu G, Wang Y, Chen Y, Ren F
Eur J Obstet Gynecol Reprod Biol 2021 Sep;264:363-367. Epub 2021 Aug 8 doi: 10.1016/j.ejogrb.2021.08.006. PMID: 34391052
PTEN immunohistochemistry in endometrial hyperplasia: which are the optimal criteria for the diagnosis of precancer?
Travaglino A, Raffone A, Saccone G, Mascolo M, Pignatiello S, Mollo A, De Placido G, Insabato L, Zullo F
APMIS 2019 Apr;127(4):161-169. doi: 10.1111/apm.12938. PMID: 30803040
Endometriosis-associated malignant transformation in abdominal surgical scar: A PRISMA-compliant systematic review.
Mihailovici A, Rottenstreich M, Kovel S, Wassermann I, Smorgick N, Vaknin Z
Medicine (Baltimore) 2017 Dec;96(49):e9136. doi: 10.1097/MD.0000000000009136. PMID: 29245355Free PMC Article
A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review.
Shoji T, Takatori E, Murakami K, Kaido Y, Takeuchi S, Kikuchi A, Sugiyama T
J Ovarian Res 2016 Aug 11;9(1):48. doi: 10.1186/s13048-016-0255-6. PMID: 27514842Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer, 2024

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...