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| Status |
Public on Dec 06, 2010 |
| Title |
Skeletal muscle gene expression in response to resistance exercise: sex specific regulation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The purpose of the study was to detect the sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, resistance exericse.
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| Overall design |
We used microarrays to profile the transcriptome of the biceps brachii of young men and women who underwent an acute unilateral RE session following 12 weeks of progressive training. Bilateral muscle biopsies were obtained either at an early (4h post-exercise) or late recovery (24h post-exercise) time point. Muscle transcription profiles were compared in the resting state between men (n=6) and women (n=8), and in response to acute RE in trained exercised vs. untrained non-exercised control muscle for each sex and time point separately (4h post-exercise, n=3 males, n=4 females; 24h post-exercise, n=3 males, n=4 females). A logistic regression-based method (LRpath), following Bayesian moderated t-statistic (IMBT), was used to test gene functional groups and biological pathways enriched with differentially expressed genes.
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| Contributor(s) |
Liu D, Sartor MA, Nader GA, Gutmann L, Treutelaar MK, Pistilli EE, IglayReger HB, Burant CF, Hoffman EP, Gordon PM |
| Citation(s) |
21106073 |
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| Submission date |
Sep 20, 2010 |
| Last update date |
Mar 25, 2019 |
| Contact name |
GORDON PAUL |
| E-mail(s) |
[email protected]
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| Organization name |
University of Michigan
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| Street address |
325 E Eisenhower
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| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48108 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (28)
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| Relations |
| BioProject |
PRJNA132933 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24235_RAW.tar |
133.0 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
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