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    Atx2 Ataxin-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41883, updated on 17-Dec-2024

    Summary

    Official Symbol
    Atx2provided by FlyBase
    Official Full Name
    Ataxin-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0041188
    Locus tag
    Dmel_CG5166
    See related
    AllianceGenome:FB:FBgn0041188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe2E1; anon-WO0118547.351; anon-WO0140519.1; atx-2; Atx-2; atx2; ATX2; Atxain-2; ATXN2; BEST:GH27029; CG43368; CG5166; CG5166a; dAtx2; Datx2; DAtx2; Dmel\CG5166; dSCA2; GH27029; l(3)06490; Sca2; SCA2
    Summary
    Enables RNA binding activity. Involved in several processes, including learning or memory; post-transcriptional regulation of gene expression; and regulation of organelle organization. Located in cytoplasmic stress granule. Is expressed in several structures, including adult brain; adult head; adult pacemaker neurons; embryonic/larval fat body; and gonad. Used to study chromosome 16p11.2 deletion syndrome, 593-kb and spinocerebellar ataxia type 2. Human ortholog(s) of this gene implicated in late onset Parkinson's disease and spinocerebellar ataxia type 2. Orthologous to several human genes including ATXN2L (ataxin 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Atx2 in Genome Data Viewer
    Location:
    88F4-88F4; 3-57 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15408423..15417277)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11234145..11242999)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RIM-binding protein Neighboring gene heineken-cup Neighboring gene antisense RNA:CR46058 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45911 Neighboring gene mir-13b-1 stem loop Neighboring gene mir-13a stem loop

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables RNA binding  
    enables mRNA binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in chaeta development PubMed 
    involved_in circadian regulation of translation PubMed 
    involved_in circadian regulation of translation PubMed 
    involved_in circadian regulation of translation PubMed 
    involved_in compound eye development PubMed 
    involved_in compound eye photoreceptor development PubMed 
    involved_in habituation PubMed 
    involved_in locomotor rhythm PubMed 
    involved_in long-term memory PubMed 
    involved_in miRNA-mediated post-transcriptional gene silencing PubMed 
    involved_in oocyte differentiation PubMed 
    involved_in positive regulation of stress granule assembly PubMed 
    involved_in regulation of actin filament polymerization PubMed 
    involved_in regulation of olfactory learning PubMed 
    involved_in regulation of synapse structural plasticity PubMed 
    NOT involved_in short-term memory PubMed 
    involved_in stress granule assembly  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    is_active_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule PubMed 
    located_in ribonucleoprotein granule PubMed 

    General protein information

    Preferred Names
    Ataxin-2
    Names
    ATAXIN-2
    Ataxin2
    Atx2-PB
    Atx2-PC
    Atx2-PD
    CG5166-PB
    CG5166-PC
    CG5166-PD
    anon-fast-evolving-2E1
    ataxin 2
    dAtaxin-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15408423..15417277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169657.3 → NP_732033.1  Ataxin-2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732033.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IHA4, Q8IHF7, Q8INE0, Q8SWR8, Q8T081, Q95U80, Q9VF64
      Related
      FBpp0082555
      Conserved Domains (1) summary
      pfam14438
      Location:61 → 128
      SM-ATX; Ataxin 2 SM domain
    2. NM_169658.3 → NP_732034.2  Ataxin-2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732034.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH64
      Related
      FBpp0082556
      Conserved Domains (1) summary
      pfam14438
      Location:1 → 67
      SM-ATX; Ataxin 2 SM domain
    3. NM_001300410.1 → NP_001287339.1  Ataxin-2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH64
      Conserved Domains (1) summary
      pfam14438
      Location:1 → 67
      SM-ATX; Ataxin 2 SM domain
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