cry cryptochrome [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cryprovided by FlyBase
Official Full Name: cryptochromeprovided by FlyBase
Primary source: FLYBASE:FBgn0025680
Locus tag: Dmel_CG3772
See related: AllianceGenome:FB:FBgn0025680
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0140519.17; anon-WO0140519.19; anon-WO0140519.20; anon-WO0172774.15; CG3772; Cry; CRY; cry1; cryb; CRYPTOCHROME; dcry; dCry; dCRY; DCry; Dm-CRY1; Dmcry; DmCry; DmCRY; DmCry1; DmCRY1; Dmel\CG3772
Summary: Enables FAD binding activity and blue light photoreceptor activity. Involved in several processes, including blue light signaling pathway; detection of light stimulus; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in several structures, including brain; inner photoreceptor cell; organism subdivision; pacemaker neurons; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 91F11-91F11; 3-66 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19212154..19215442)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (15037876..15041164)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cryptochrome-Timeless structure reveals circadian clock timing mechanisms.
Title: Cryptochrome-Timeless structure reveals circadian clock timing mechanisms.
Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome.
Title: Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome.
pH-dependence of signaling-state formation in Drosophila cryptochrome.
Title: pH-dependence of signaling-state formation in Drosophila cryptochrome.
CRY-dependent plasticity of tetrad presynaptic sites in the visual system of Drosophila at the morning peak of activity and sleep.
Title: CRY-dependent plasticity of tetrad presynaptic sites in the visual system of Drosophila at the morning peak of activity and sleep.
The W420 tryptophan residue located closest to the FAD-dCRY interaction site is critical for blue- and UV-light-evoked electrophysiological responses, while other tryptophan residues within electron transfer distance to W420 do not appear to be required for light-evoked electrophysiological responses.
Title: Distinct mechanisms of Drosophila CRYPTOCHROME-mediated light-evoked membrane depolarization and in vivo clock resetting.
photo-induced electron transfer reactions in Drosophila melanogaster cryptochrome are indeed influenced by magnetic fields of a few millitesla.
Title: Millitesla magnetic field effects on the photocycle of an animal cryptochrome.
Substitutions of four key Trp residues to redox-active tyrosine and redox-inactive phenylalanine tune the light sensitivity of dCRY photoreduction, conformational activation, cellular stability, and targeted degradation of the clock protein timeless
Title: Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction.
we identify the circadian blue-light photoreceptor CRYPTOCHROME as a molecular regulator of Prolonged Morning Wakefulness (PMW), and propose a model in which the Drosophila nervous system integrates information encoding temperature, light, and time to dynamically control when sleep is initiated. Our results provide a platform to investigate how environmental inputs co-ordinately regulate sleep plasticity.
Title: Regulation of sleep plasticity by a thermo-sensitive circuit in Drosophila.
The findings of this article for the first time define CRY expression in Drosophila peripheral tissues and reveal that CRY acts together with K(+) channels to maintain passive membrane properties in a non-clock-containing peripheral tissue independent of light.
Title: Drosophila CRY Entrains Clocks in Body Tissues to Light and Maintains Passive Membrane Properties in a Non-clock Body Tissue Independent of Light.
Changes in active site histidine hydrogen bonding trigger cryptochrome activation.
Title: Changes in active site histidine hydrogen bonding trigger cryptochrome activation.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables DNA photolyase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables FAD binding	IDA Inferred from Direct Assay more info	PubMed
enables blue light photoreceptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables flavin adenine dinucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables photoreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables photoreceptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in UV-A, blue light phototransduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in blue light signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in circadian behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IPI Inferred from Physical Interaction more info	PubMed
involved_in detection of light stimulus involved in magnetoreception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock	IDA Inferred from Direct Assay more info	PubMed
involved_in entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock by photoperiod	IGI Inferred from Genetic Interaction more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gravitaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in magnetoreception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to blue light	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to magnetism	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cryptochrome

Names: Blue-light receptor; CG3772-PA; cry-PA; crybaby; crypochrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

19212154..19215442

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169852.2 → NP_732407.1 cryptochrome [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732407.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77059, Q9TYA0

Related

FBpp0083150

Conserved Domains (2) summary

cl30787
Location:4 → 504

PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]

pfam03441
Location:310 → 510

FAD_binding_7; FAD binding domain of DNA photolyase