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cry cryptochrome [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42305, updated on 9-Dec-2024

Summary

Official Symbol
cryprovided by FlyBase
Official Full Name
cryptochromeprovided by FlyBase
Primary source
FLYBASE:FBgn0025680
Locus tag
Dmel_CG3772
See related
AllianceGenome:FB:FBgn0025680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.17; anon-WO0140519.19; anon-WO0140519.20; anon-WO0172774.15; CG3772; Cry; CRY; cry1; cryb; CRYPTOCHROME; dcry; dCry; dCRY; DCry; Dm-CRY1; Dmcry; DmCry; DmCRY; DmCry1; DmCRY1; Dmel\CG3772
Summary
Enables FAD binding activity and blue light photoreceptor activity. Involved in several processes, including blue light signaling pathway; detection of light stimulus; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in several structures, including brain; inner photoreceptor cell; organism subdivision; pacemaker neurons; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See cry in Genome Data Viewer
Location:
91F11-91F11; 3-66 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19212154..19215442)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15037876..15041164)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mayday Neighboring gene long non-coding RNA:CR46039 Neighboring gene long non-coding RNA:CR46393 Neighboring gene vibrator Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables DNA photolyase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables blue light photoreceptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables flavin adenine dinucleotide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables photoreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables photoreceptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in UV-A, blue light phototransduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in blue light signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in circadian behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in detection of light stimulus involved in magnetoreception IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in entrainment of circadian clock IDA
Inferred from Direct Assay
more info
PubMed 
involved_in entrainment of circadian clock IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in entrainment of circadian clock by photoperiod IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gravitaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in magnetoreception IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to blue light IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to magnetism IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cryptochrome
Names
Blue-light receptor
CG3772-PA
cry-PA
crybaby
crypochrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19212154..19215442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169852.2NP_732407.1  cryptochrome [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732407.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77059, Q9TYA0
    Related
    FBpp0083150
    Conserved Domains (2) summary
    cl30787
    Location:4504
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam03441
    Location:310510
    FAD_binding_7; FAD binding domain of DNA photolyase