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Pdp1 PAR-domain protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45588, updated on 9-Dec-2024

Summary

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Official Symbol
Pdp1provided by FlyBase
Official Full Name
PAR-domain protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0016694
Locus tag
Dmel_CG17888
See related
AllianceGenome:FB:FBgn0016694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.206; CG17888; DM1; DM32; Dmel\CG17888; mel_pdp1; pdp; PDP; Pdp-1; PDP-1epsilon; pdp1; PDP1; Pdp1 epsilon; PDP1 epsilon; Pdp1&e;gr; Pdp1e; pdp1epsilon; Pdp1epsilon; PDP1epsilon
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in circadian rhythm; positive regulation of DNA-templated transcription; and regulation of lipid metabolic process. Located in nucleus. Is expressed in several structures, including adult pacemaker neurons; gut section; midgut primordium; pharyngeal muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to several human genes including HLF (HLF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Pdp1 in Genome Data Viewer
Location:
66A14-66A17; 3-21 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7811458..7867369, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7804558..7860469, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Clock Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 4E5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila PAR domain protein 1 (Pdp1) gene encodes multiple differentially expressed mRNAs and proteins through the use of multiple enhancers and promoters. Reddy KL, et al. Dev Biol, 2000 Aug 15. PMID 10926776
  2. Reduction of Cellular Lipid Content by a Knockdown of Drosophila PDP1 γ and Mammalian Hepatic Leukemia Factor. Dzitoyeva S, et al. J Lipids, 2013. PMID 24062952, Free PMC Article
  3. Cryptochrome-dependent and -independent circadian entrainment circuits in Drosophila. Yoshii T, et al. J Neurosci, 2015 Apr 15. PMID 25878285, Free PMC Article
  4. Co-operation between enhancers modulates quantitative expression from the Drosophila Paramyosin/miniparamyosin gene in different muscle types. Marco-Ferreres R, et al. Mech Dev, 2005 May. PMID 15817225
  5. The Drosophila Par domain protein I gene, Pdp1, is a regulator of larval growth, mitosis and endoreplication. Reddy KL, et al. Dev Biol, 2006 Jan 1. PMID 16313897

See all (228) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Candidate proteins with strong PRBH signals associated with the cell cortex but were displaced into the cytoplasm by aPKC. These findings demonstrate a potentially general mechanism for exclusion of proteins from the Par cortical domain in polarized cell
    Title: Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.
  2. Our data uncover a pathway from the positive arm of the circadian clock through Pdp1 to detoxification effector genes, demonstrating a conserved role of the circadian system in modulating xenobiotic toxicity.
    Title: Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway.
  3. Data show that takeout levels are low in flies with reduced Pdp1epsilon and high in flies with increased amounts of Pdp1epsilon.
    Title: The circadian output gene takeout is regulated by Pdp1epsilon.
  4. Transgenic expression of PDP1 epsilon in clock neurons of Pdp1 epsilon mutants can restore rhythmic circadian behavior.
    Title: An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator.
  5. PDP1-target genes may be involved in the formation of neural connection between the pacemaker cells and their targets for maintaining the rhythmicity of adult locomotor activity under free-running condition.
    Title: Targeted inhibition of Pdp1epsilon abolishes the circadian behavior of Drosophila melanogaster.
  6. Clk, vri, and Pdp-1 have roles in controlling Drosophila circadian oscillations, as shown in a simulation
    Title: Simulation of Drosophila circadian oscillations, mutations, and light responses by a model with VRI, PDP-1, and CLK.
  7. Pdp1 has a critical role in coordinating growth and DNA replication.
    Title: The Drosophila Par domain protein I gene, Pdp1, is a regulator of larval growth, mitosis and endoreplication.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in circadian rhythm IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in circadian rhythm IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian rhythm TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
PAR-domain protein 1
Names
CG17888-PB
CG17888-PC
CG17888-PD
CG17888-PF
CG17888-PG
CG17888-PI
CG17888-PJ
CG17888-PK
CG17888-PL
CG17888-PM
CG17888-PN
CG17888-PO
CG17888-PP
PAR domain protein 1epsilon
PAR-DOMAIN-PROTEIN 1
PAR-Domain protein 1
PAR-protein domain1
Par domain protein 1
Pdp1-PB
Pdp1-PC
Pdp1-PD
Pdp1-PF
Pdp1-PG
Pdp1-PI
Pdp1-PJ
Pdp1-PK
Pdp1-PL
Pdp1-PM
Pdp1-PN
Pdp1-PO
Pdp1-PP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7811458..7867369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080093.5 → NP_524832.3  PAR-domain protein 1, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524832.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KKI2, Q86P99
    Conserved Domains (1) summary
    cd14695
    Location:203 → 262
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  2. NM_001300044.1 → NP_001286973.1  PAR-domain protein 1, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286973.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KKI2, Q86P99
    Conserved Domains (1) summary
    cd14695
    Location:203 → 262
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  3. NM_168233.3 → NP_729297.1  PAR-domain protein 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729297.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL48, Q9TVQ4
    Related
    FBpp0076490
    Conserved Domains (1) summary
    cd14695
    Location:183 → 242
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  4. NM_001274618.1 → NP_001261547.1  PAR-domain protein 1, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261547.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBV3, Q86P99
    Conserved Domains (1) summary
    cd14695
    Location:197 → 256
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  5. NM_168234.3 → NP_729298.2  PAR-domain protein 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729298.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24217, Q86P99, Q9TVF8
    Conserved Domains (1) summary
    cd14695
    Location:165 → 224
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  6. NM_168235.3 → NP_729299.1  PAR-domain protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729299.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KKI2, Q86P99
    Related
    FBpp0076491
    Conserved Domains (1) summary
    cd14695
    Location:203 → 262
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  7. NM_001274616.1 → NP_001261545.1  PAR-domain protein 1, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261545.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEP3, Q86P99
    Conserved Domains (1) summary
    cd14695
    Location:208 → 267
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  8. NM_001274617.1 → NP_001261546.1  PAR-domain protein 1, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261546.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U8V5, Q86P99
    Conserved Domains (1) summary
    cd14695
    Location:214 → 273
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  9. NM_168236.3 → NP_729300.1  PAR-domain protein 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729300.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P99, Q9TW49
    Related
    FBpp0076492
    Conserved Domains (1) summary
    cd14695
    Location:217 → 276
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  10. NM_168238.3 → NP_729302.2  PAR-domain protein 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729302.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQ99
    Conserved Domains (1) summary
    cd14695
    Location:566 → 625
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  11. NM_168237.2 → NP_729301.1  PAR-domain protein 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729301.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZT1
    Related
    FBpp0076495
    Conserved Domains (1) summary
    cd14695
    Location:580 → 639
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  12. NM_001274615.1 → NP_001261544.1  PAR-domain protein 1, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEX4
    Conserved Domains (1) summary
    cd14695
    Location:514 → 573
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  13. NM_168239.2 → NP_729303.1  PAR-domain protein 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729303.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQ98
    Related
    FBpp0076497
    Conserved Domains (1) summary
    cd14695
    Location:503 → 562
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBV3 M9PBV3
M9PEP3 M9PEP3
M9PEX4 M9PEX4
Q24217 Q24217
Q5U8V5 Q5U8V5
Q7KKI2 Q7KKI2
Q86P99 Q86P99
Q8IQ98 Q8IQ98
Q8IQ99 Q8IQ99
Q8SZT1 Q8SZT1
Q9TVQ4 Q9TVQ4
Q9TVS7 Q9TVS7
Q9TVY0 Q9TVY0
Q9TW49 Q9TW49

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