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CG10077 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38756, updated on 9-Dec-2024

Summary

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Official Symbol
CG10077provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035720
Locus tag
Dmel_CG10077
See related
AllianceGenome:FB:FBgn0035720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:HL01868; BcDNA:HL07910; cg10077; Dmel\CG10077; DmRH5; p90
Summary
Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Orthologous to several human genes including DDX17 (DEAD-box helicase 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG10077 in Genome Data Viewer
Location:
65D3-65D4; 3-18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6949491..6955904, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6942591..6949004, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45412 Neighboring gene target of wingless Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase complex assembly factor 1 Neighboring gene Surfeit 1 Neighboring gene sugarless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila. Rodriguez J, et al. Mol Cell, 2012 Jul 13. PMID 22658416, Free PMC Article
  2. Diverse cell-specific patterns of alternative polyadenylation in Drosophila. Lee S, et al. Nat Commun, 2022 Sep 13. PMID 36100597, Free PMC Article
  3. Whole-genome analysis reveals that active heat shock factor binding sites are mostly associated with non-heat shock genes in Drosophila melanogaster. Gonsalves SE, et al. PLoS One, 2011 Jan 14. PMID 21264254, Free PMC Article
  4. Transcripts immunoprecipitated with Sxl protein in primordial germ cells of Drosophila embryos. Ota R, et al. Dev Growth Differ, 2017 Dec. PMID 29124738
  5. Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila. Ayers KL, et al. Dev Biol, 2009 May 15. PMID 19285058

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10077-PA
CG10077-PC
CG10077-PD
NP_001261491.1
NP_648062.2
NP_729194.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6949491..6955904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139805.2 → NP_648062.2  uncharacterized protein Dmel_CG10077, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648062.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZI3, Q9VRZ5
    Related
    FBpp0076649
    Conserved Domains (3) summary
    cd00079
    Location:375 → 507
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:159 → 364
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:49 → 544
    PTZ00110; helicase; Provisional

  2. NM_001274562.1 → NP_001261491.1  uncharacterized protein Dmel_CG10077, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261491.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZI3, Q9VRZ5
    Conserved Domains (3) summary
    cd00079
    Location:375 → 507
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:159 → 364
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:49 → 544
    PTZ00110; helicase; Provisional

  3. NM_168182.3 → NP_729194.2  uncharacterized protein Dmel_CG10077, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729194.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KU78
    Conserved Domains (3) summary
    smart00487
    Location:172 → 379
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:375 → 468
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:159 → 364
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KU78 Q7KU78
Q8MRJ6 Q8MRJ6
Q8MZI3 Q8MZI3
Q8T0I3 Q8T0I3

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