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InR Insulin-like receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42549, updated on 4-Jan-2025

Summary

Official Symbol
InRprovided by FlyBase
Official Full Name
Insulin-like receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0283499
Locus tag
Dmel_CG18402
See related
AllianceGenome:FB:FBgn0283499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
18402; CG18402; DIHR; DILR; dinr; dinR; dInr; dInR; dINR; DInr; DInR; dInsR; dINSR; dir; dIR; DIR; Dir-a; Dir-b; DIRbeta; dIRH; DIRH; Dmel\CG18402; er10; Igfr1; inr; inR; Inr; INR; Inr-alpha; Inr-beta; INS; InsR; insulin/insulin-like growth factor receptor; IR; l(3)05545; l(3)93Dj; l(3)er10; lnR; RTK; sprout
Summary
Enables insulin binding activity and insulin receptor activity. Involved in several processes, including germ cell development; negative regulation of behavior; and positive regulation of cell development. Located in plasma membrane. Part of insulin receptor complex. Is expressed in several structures, including adult fat body; corpus allatum; ganglia; gut section; and somatic precursor cell. Used to study alcohol dependence; diabetic neuropathy; glucose metabolism disease (multiple); high grade glioma; and sleep disorder. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); glucose metabolism disease (multiple); kidney cancer (multiple); liver disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including IGF1R (insulin like growth factor 1 receptor) and INSRR (insulin receptor related receptor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See InR in Genome Data Viewer
Location:
93E4-93E9; 3-72 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21570248..21619321, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17395970..17445043, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene slouch Neighboring gene uncharacterized protein Neighboring gene Insulin receptor-associated lncRNA Neighboring gene long non-coding RNA:CR44034 Neighboring gene mir-998 stem loop Neighboring gene mir-11 stem loop Neighboring gene E2F transcription factor 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

mobile_element

  • Loc: c21610044-21609899 mobile_element_type = transposon:NOF{}1401

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding  
enables insulin binding PubMed 
enables insulin binding  
enables insulin receptor activity  
enables insulin receptor activity PubMed 
enables insulin receptor activity PubMed 
enables insulin receptor substrate binding  
enables insulin receptor substrate binding  
enables phosphatidylinositol 3-kinase binding  
enables protein binding PubMed 
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase activity PubMed 
enables transmembrane receptor protein tyrosine kinase activity  
Items 1 - 25 of 65
Process Evidence Code Pubs
involved_in axon guidance PubMed 
involved_in carbohydrate homeostasis PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in cellular response to starvation PubMed 
involved_in cholesterol homeostasis PubMed 
involved_in circadian rhythm PubMed 
involved_in determination of adult lifespan PubMed 
involved_in developmental growth PubMed 
involved_in embryo development ending in birth or egg hatching PubMed 
involved_in embryonic development via the syncytial blastoderm PubMed 
involved_in female germ-line stem cell asymmetric division PubMed 
involved_in female germ-line stem cell population maintenance PubMed 
involved_in female gonad development PubMed 
involved_in female mating behavior PubMed 
involved_in follicle cell of egg chamber development PubMed 
involved_in germ-band shortening PubMed 
involved_in germ-line stem cell division PubMed 
involved_in germ-line stem-cell niche homeostasis PubMed 
involved_in glucose homeostasis  
involved_in glucose homeostasis PubMed 
involved_in imaginal disc growth PubMed 
involved_in insulin receptor signaling pathway PubMed 
involved_in insulin receptor signaling pathway PubMed 
involved_in insulin receptor signaling pathway PubMed 
involved_in intestinal stem cell homeostasis PubMed 
involved_in lipid homeostasis PubMed 
involved_in locomotory behavior PubMed 
involved_in lymph gland development PubMed 
involved_in male germ-line stem cell asymmetric division PubMed 
involved_in multicellular organism development  
involved_in multicellular organism growth PubMed 
involved_in negative regulation of circadian sleep/wake cycle, sleep PubMed 
involved_in negative regulation of entry into reproductive diapause PubMed 
involved_in negative regulation of feeding behavior PubMed 
involved_in negative regulation of macroautophagy PubMed 
involved_in negative regulation of peptide hormone secretion PubMed 
involved_in nervous system development PubMed 
involved_in open tracheal system development PubMed 
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of border follicle cell migration PubMed 
involved_in positive regulation of cell growth PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of cell size PubMed 
involved_in positive regulation of fat cell proliferation PubMed 
involved_in positive regulation of lipid storage PubMed 
involved_in positive regulation of multicellular organism growth PubMed 
involved_in positive regulation of neuroblast proliferation PubMed 
involved_in positive regulation of neuron remodeling PubMed 
involved_in positive regulation of organ growth PubMed 
involved_in positive regulation of organ growth PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of wound healing PubMed 
involved_in primary spermatocyte growth PubMed 
involved_in protein autophosphorylation  
involved_in protein phosphorylation  
involved_in protein phosphorylation PubMed 
involved_in regulation of cell population proliferation PubMed 
involved_in regulation of multicellular organism growth PubMed 
involved_in regulation of organ growth PubMed 
involved_in response to anoxia PubMed 
involved_in response to cocaine PubMed 
involved_in response to oxidative stress PubMed 
involved_in triglyceride homeostasis PubMed 
Items 1 - 25 of 65
Component Evidence Code Pubs
is_active_in axon  
part_of insulin receptor complex  
part_of insulin receptor complex PubMed 
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane PubMed 

General protein information

Preferred Names
Insulin-like receptor
Names
CG18402-PA
CG18402-PB
CG18402-PC
CG18402-PD
Igf-1 receptor
InR-PA
InR-PB
InR-PC
InR-PD
Insulin-receptor
drosophila insulin receptor
insulin
insulin receptor
insulin receptor homolog
insulin receptor homologue
insulin-like receptor
insulin-like receptor tyrosine kinase
insulin/IGF receptor
lethal(3)93Dj
sprout
NP_001138093.1
NP_001138094.1
NP_001138095.1
NP_524436.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21570248..21619321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144621.3 → NP_001138093.1  Insulin-like receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138093.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0N6, P09208, Q24023, Q24089, Q9VD94
    UniProtKB/TrEMBL
    A0A7T4WRU1
    Conserved Domains (6) summary
    cd05032
    Location:1364 → 1652
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:1224 → 1302
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:545 → 592
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:512 → 645
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:356 → 465
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1371 → 1650
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_079712.6 → NP_524436.2  Insulin-like receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524436.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0N6, P09208, Q24023, Q24089, Q9VD94
    UniProtKB/TrEMBL
    A0A7T4WRU1
    Related
    FBpp0083519
    Conserved Domains (6) summary
    cd05032
    Location:1364 → 1652
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:1224 → 1302
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:545 → 592
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:512 → 645
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:356 → 465
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1371 → 1650
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_001144622.2 → NP_001138094.1  Insulin-like receptor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138094.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0N6, P09208, Q24023, Q24089, Q9VD94
    UniProtKB/TrEMBL
    A0A7T4WRU1
    Conserved Domains (6) summary
    cd05032
    Location:1364 → 1652
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:1224 → 1302
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:545 → 592
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:512 → 645
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:356 → 465
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1371 → 1650
    Pkinase_Tyr; Protein tyrosine kinase
  4. NM_001144623.2 → NP_001138095.1  Insulin-like receptor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138095.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0N6, P09208, Q24023, Q24089, Q9VD94
    UniProtKB/TrEMBL
    A0A7T4WRU1
    Conserved Domains (6) summary
    cd05032
    Location:1364 → 1652
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:1224 → 1302
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:545 → 592
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:512 → 645
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:356 → 465
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1371 → 1650
    Pkinase_Tyr; Protein tyrosine kinase
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