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Lnk Lnk [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43130, updated on 4-Jan-2025

Summary

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Official Symbol
Lnkprovided by FlyBase
Official Full Name
Lnkprovided by FlyBase
Primary source
FLYBASE:FBgn0028717
Locus tag
Dmel_CG17367
See related
AllianceGenome:FB:FBgn0028717
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG 17367; CG17367; CG5908; Dmel\CG17367; dSH2B; lnk; LNK; SH2B
Summary
Enables transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of protein localization to cell cortex. Located in cell cortex. Is expressed in adult fat body; adult gut; adult head; hypodermal muscle cell of A1-7; and indirect flight muscle cell. Used to study chromosome 16p11.2 deletion syndrome, 220-kb. Human ortholog(s) of this gene implicated in colorectal cancer; essential thrombocythemia; familial erythrocytosis 1; myelofibrosis; and type 1 diabetes mellitus. Orthologous to several human genes including SH2B1 (SH2B adaptor protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Lnk in Genome Data Viewer
Location:
96F6-96F6; 3-89 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25888542..25893270)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21714264..21718992)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tetraspanin 96F Neighboring gene Signal peptide peptidase-like Neighboring gene uncharacterized protein Neighboring gene Sodesque

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A reverse genetic screen in Drosophila using a deletion-inducing mutagen. Nairz K, et al. Genome Biol, 2004. PMID 15461801, Free PMC Article
  2. SH2B1 is Involved in the Accumulation of Amyloid-β42 in Alzheimer's Disease. Shen Y, et al. J Alzheimers Dis, 2017. PMID 27802221
  3. The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction. Almudi I, et al. Cell Commun Signal, 2013 Apr 16. PMID 23590848, Free PMC Article
  4. Nutrient-Response Pathways in Healthspan and Lifespan Regulation. Dabrowska A, et al. Cells, 2022 May 6. PMID 35563873, Free PMC Article
  5. The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway. Werz C, et al. PLoS Genet, 2009 Aug. PMID 19680438, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phenotypic analysis of mutants for Lnk revealed that loss of Lnk function results in increased lifespan and improved survival under conditions of oxidative stress and starvation.
    Title: Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.
  2. Lnk acts in parallel to Chico downstream of the insulin receptor to regulate cellular growth.
    Title: The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to cell cortex IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Lnk
Names
CG17367-PA
CG17367-PB
CG17367-PC
CG17367-PD
CG17367-PE
CG17367-PF
Lnk-PA
Lnk-PB
Lnk-PC
Lnk-PD
Lnk-PE
Lnk-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25888542..25893270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170247.2 → NP_733126.1  Lnk, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733126.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K137
    Related
    FBpp0084309
    Conserved Domains (4) summary
    cd10346
    Location:433 → 529
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:197 → 308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:215 → 307
    PH; PH domain
    pfam08916
    Location:67 → 125
    Phe_ZIP; Phenylalanine zipper

  2. NM_001300608.1 → NP_001287537.1  Lnk, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287537.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHS0
    Conserved Domains (4) summary
    cd10346
    Location:438 → 534
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:202 → 313
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:220 → 312
    PH; PH domain
    pfam08916
    Location:67 → 125
    Phe_ZIP; Phenylalanine zipper

  3. NM_001300607.1 → NP_001287536.1  Lnk, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287536.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHY5
    Conserved Domains (4) summary
    cd10346
    Location:438 → 534
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:202 → 313
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:220 → 312
    PH; PH domain
    pfam08916
    Location:67 → 125
    Phe_ZIP; Phenylalanine zipper

  4. NM_170246.2 → NP_733125.1  Lnk, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733125.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K137
    Related
    FBpp0084311
    Conserved Domains (4) summary
    cd10346
    Location:433 → 529
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:197 → 308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:215 → 307
    PH; PH domain
    pfam08916
    Location:67 → 125
    Phe_ZIP; Phenylalanine zipper

  5. NM_001300609.1 → NP_001287538.1  Lnk, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287538.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LIP5
    Conserved Domains (4) summary
    cd10346
    Location:433 → 529
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:197 → 308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:215 → 307
    PH; PH domain
    pfam08916
    Location:67 → 125
    Phe_ZIP; Phenylalanine zipper

  6. NM_143181.3 → NP_651438.1  Lnk, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651438.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K137
    Related
    FBpp0084310
    Conserved Domains (4) summary
    cd10346
    Location:433 → 529
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:197 → 308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:215 → 307
    PH; PH domain
    pfam08916
    Location:67 → 125
    Phe_ZIP; Phenylalanine zipper
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHS0 A0A0B4LHS0
A0A0B4LHY5 A0A0B4LHY5
A0A0B4LIP5 A0A0B4LIP5
Q7K137 Q7K137
Q9U8B9 Q9U8B9

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