CNBP CCHC-type zinc finger nucleic acid binding protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CNBPprovided by FlyBase
Official Full Name: CCHC-type zinc finger nucleic acid binding proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0034802
Locus tag: Dmel_CG3800
See related: AllianceGenome:FB:FBgn0034802
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:fe1B4; anon-EST:fe2B6; BEST:GM06241; CG11716; CG3800; dCNBP; Dmel\CG3800
Summary: Predicted to enable mRNA binding activity; single-stranded RNA binding activity; and translation regulator activity. Involved in IRES-dependent translational initiation of linear mRNA and wing disc morphogenesis. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; adult heart; central brain primordium; embryonic/larval midgut primordium; and ganglia. Used to study myotonic dystrophy type 2. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to several human genes including ZCCHC13 (zinc finger CCHC-type containing 13). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22934569..22937077, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18822092..18824600, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

by regulating dMyc IRES-dependent translation, CNBP controls Drosophila wing development.
Title: CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRES-dependent translational initiation of linear mRNA	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

Names: CG3800-PA; CG3800-PB; CNBP-PA; CNBP-PB; anon-fast-evolving-1B4; anon-fast-evolving-2B6

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The following sections contain reference sequences that belong to a specific genome build. Explain