Lar Leukocyte-antigen-related-like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Larprovided by FlyBase
Official Full Name: Leukocyte-antigen-related-likeprovided by FlyBase
Primary source: FLYBASE:FBgn0000464
Locus tag: Dmel_CG10443
See related: AllianceGenome:FB:FBgn0000464
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10443; dlar; Dlar; DLar; DLAR; Dmel\CG10443; lar; LAR; Ptp38A; PTP38A
Summary: Enables SAM domain binding activity; insulin receptor binding activity; and transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including centripetally migrating follicle cell migration; hematopoietic stem cell homeostasis; and neuron development. Located in several cellular components, including basal plasma membrane; cell surface; and focal adhesion. Is expressed in several structures, including adult head; central nervous system; larval ventral nerve cord; male germline cell; and tract. Used to study azoospermia. Human ortholog(s) of this gene implicated in coronary artery disease; diabetes mellitus; hyperinsulinism; hypertension; and type 2 diabetes mellitus. Orthologous to several human genes including PTPRD (protein tyrosine phosphatase receptor type D) and PTPRF (protein tyrosine phosphatase receptor type F). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 37F2-38A2; 2-54 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19586623..19732069)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19586623..19732069)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells.
Title: Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells.
Lar physically associates with InR and serves as a negative regulator for insulin signaling in the Drosophila larval hematopoietic niche.
Title: Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche.
Sema-5c antagonizes the activity of Lar, another transmembrane guidance cue that operates along leading-trailing cell-cell interfaces in this tissue, via a mechanism that appears to be independent of Plexin A.
Title: Planar-Polarized Semaphorin-5c and Plexin A Promote the Collective Migration of Epithelial Cells in Drosophila.
The authors found that the depth of the final layer of stable photoreceptor axon termination relied primarily on the cumulative amount of LAR and Ptp69D cytoplasmic activity, while specific features of their ectodomains contribute to the choice between two synaptic layers, M3 and M6, in the medulla.
Title: Two receptor tyrosine phosphatases dictate the depth of axonal stabilizing layer in the visual system.
Fat2/Lar signaling mediates short-range communication between neighboring cells instead of transmitting long-range information across a tissue.
Title: Fat2 and Lar Define a Basally Localized Planar Signaling System Controlling Collective Cell Migration.
The results of this study suggested that loss of Lar alters sLNv axonal targeting in the dorsal protocerebrum during embryonic or early larval development, thereby impairing PDF signaling, synchronization of the circadian network, and rhythmic activity.
Title: The Drosophila Receptor Protein Tyrosine Phosphatase LAR Is Required for Development of Circadian Pacemaker Neuron Processes That Support Rhythmic Activity in Constant Darkness But Not during Light/Dark Cycles.
the Lar receptor tyrosine phosphatase appears to polarize and retain GSCs through maintenance of localized E-cadherin-based adherens junctions
Title: The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche.
the crystal structures of the first and second immunoglobulin-like domains of the Drosophila type IIa receptor Dlar and its mouse homolog LAR were reported.
Title: The immunoglobulin-like domains 1 and 2 of the protein tyrosine phosphatase LAR adopt an unusual horseshoe-like conformation.
Drosophila caskin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically with the leukocyte common antigen-related
Title: The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance.
Data demonstrate that N-cadherin, DLAR, and Liprin-alpha function in a complex to regulate adhesive interactions between pre- and post-synaptic cells and provide a novel mechanism for controlling the activity of Liprin-alpha in the developing growth cone.
Title: Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 19620154-19621069 mobile_element_type = transposon:jockey{}413
Loc: 19652628-19674003 mobile_element_type = transposon:roo{}1676
Loc: 19668468-19673190 mobile_element_type = transposon:Doc{}417
Loc: 19688080-19688131 mobile_element_type = transposon:INE-1{}3986

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SAM domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in R7 cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centripetally migrating follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of homophilic cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of plasma membrane bounded cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Leukocyte-antigen-related-like

Names: CG10443-PA; CG10443-PB; CG10443-PD; CG10443-PF; CG10443-PG; CG10443-PH; CG10443-PI; LAR receptor tyrosine phosphatase; Lar-PA; Lar-PB; Lar-PD; Lar-PF; Lar-PG; Lar-PH; Lar-PI; bypass; leukocyte- antigen-related-like; leukocyte-antigen-related-like

NP_001246094.1

EC 3.1.3.-

EC 3.1.3.48

NP_001260594.1

EC 3.1.3.-

EC 3.1.3.48

NP_001260595.1

EC 3.1.3.-

EC 3.1.3.48

NP_001260596.1

EC 3.1.3.-

EC 3.1.3.48

NP_001260597.1

EC 3.1.3.-

EC 3.1.3.48

NP_523604.2

EC 3.1.3.-

EC 3.1.3.48

NP_724220.2

EC 3.1.3.-

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

19586623..19732069

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273668.1 → NP_001260597.1 Leukocyte-antigen-related-like, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260597.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PG93

Conserved Domains (8) summary

cd05739
Location:263 → 331

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1672 → 1931

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:160 → 241

IG_like; Immunoglobulin like

cd00047
Location:1412 → 1640

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:429 → 520

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:50 → 143

I-set; Immunoglobulin I-set domain

pfam00041
Location:338 → 418

fn3; Fibronectin type III domain

cl11960
Location:173 → 242

Ig; Immunoglobulin domain
NM_001273667.1 → NP_001260596.1 Leukocyte-antigen-related-like, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260596.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDF7

Conserved Domains (8) summary

cd05739
Location:249 → 317

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1658 → 1917

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:146 → 227

IG_like; Immunoglobulin like

cd00047
Location:1398 → 1626

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:415 → 506

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:36 → 129

I-set; Immunoglobulin I-set domain

pfam00041
Location:324 → 404

fn3; Fibronectin type III domain

cl11960
Location:159 → 228

Ig; Immunoglobulin domain
NM_165313.4 → NP_724220.2 Leukocyte-antigen-related-like, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724220.2

Status: REVIEWED

UniProtKB/TrEMBL

A8DZ18

Conserved Domains (8) summary

cd05739
Location:231 → 299

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1742 → 2001

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:128 → 209

IG_like; Immunoglobulin like

cd00047
Location:1482 → 1710

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:400 → 491

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:18 → 111

I-set; Immunoglobulin I-set domain

pfam00041
Location:306 → 386

fn3; Fibronectin type III domain

cl11960
Location:141 → 210

Ig; Immunoglobulin domain
NM_001273666.1 → NP_001260595.1 Leukocyte-antigen-related-like, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260595.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDR3

Conserved Domains (8) summary

cd05739
Location:249 → 317

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1666 → 1925

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:146 → 227

IG_like; Immunoglobulin like

cd00047
Location:1406 → 1634

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:423 → 514

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:36 → 129

I-set; Immunoglobulin I-set domain

pfam00041
Location:324 → 404

fn3; Fibronectin type III domain

cl11960
Location:159 → 228

Ig; Immunoglobulin domain
NM_001273665.1 → NP_001260594.1 Leukocyte-antigen-related-like, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260594.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PD76

Conserved Domains (8) summary

cd05739
Location:249 → 317

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1763 → 2022

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:146 → 227

IG_like; Immunoglobulin like

cd00047
Location:1503 → 1731

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:423 → 514

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:36 → 129

I-set; Immunoglobulin I-set domain

pfam00041
Location:324 → 404

fn3; Fibronectin type III domain

cl11960
Location:159 → 228

Ig; Immunoglobulin domain
NM_001259165.1 → NP_001246094.1 Leukocyte-antigen-related-like, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246094.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NCY3

Conserved Domains (8) summary

cd05739
Location:231 → 299

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1643 → 1902

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:128 → 209

IG_like; Immunoglobulin like

cd00047
Location:1383 → 1611

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:400 → 491

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:18 → 111

I-set; Immunoglobulin I-set domain

pfam00041
Location:306 → 386

fn3; Fibronectin type III domain

cl11960
Location:141 → 210

Ig; Immunoglobulin domain
NM_078880.3 → NP_523604.2 Leukocyte-antigen-related-like, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523604.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P16621, Q960M3, Q9VIS8

Related

FBpp0080801

Conserved Domains (8) summary

cd05739
Location:249 → 317

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1760 → 2019

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:146 → 227

IG_like; Immunoglobulin like

cd00047
Location:1500 → 1728

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:418 → 509

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:36 → 129

I-set; Immunoglobulin I-set domain

pfam00041
Location:324 → 404

fn3; Fibronectin type III domain

cl11960
Location:159 → 228

Ig; Immunoglobulin domain