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Elp6 Elongator complex protein 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41641, updated on 4-Jan-2025

Summary

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Official Symbol
Elp6provided by FlyBase
Official Full Name
Elongator complex protein 6provided by FlyBase
Primary source
FLYBASE:FBgn0086371
Locus tag
Dmel_CG9829
See related
AllianceGenome:FB:FBgn0086371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0081/31; CG9829; did; did/alt1; Dmel\CG9829; l(3)05137; l(3)S008131; poly
Summary
Enables insulin receptor binding activity. Involved in melanotic encapsulation of foreign target; microtubule cytoskeleton organization; and positive regulation of insulin receptor signaling pathway. Part of elongator holoenzyme complex. Orthologous to human ELP6 (elongator acetyltransferase complex subunit 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Elp6 in Genome Data Viewer
Location:
87E7-87E8; 3-53 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13361816..13366910, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9187538..9192632, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pyrokinin 2 receptor 1 Neighboring gene methuselah-like 12 Neighboring gene Dicarboxylate carrier 1 Neighboring gene Chemosensory protein A 87a Neighboring gene Lipase 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. poly is required for nurse-cell chromosome dispersal and oocyte polarity in Drosophila. Klusza S, et al. Fly (Austin), 2010 Apr-Jun. PMID 20473032, Free PMC Article
  2. Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants. Planelles-Herrero VJ, et al. Nat Cell Biol, 2022 Nov. PMID 36302967, Free PMC Article
  3. Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Bolukbasi E, et al. Open Biol, 2012 Jan. PMID 22645656, Free PMC Article
  4. Dissection of Complex, Fitness-Related Traits in Multiple Drosophila Mapping Populations Offers Insight into the Genetic Control of Stress Resistance. Everman ER, et al. Genetics, 2019 Apr. PMID 30760490, Free PMC Article
  5. Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila. Kim M, et al. Genetics, 2021 Mar 3. PMID 33683365, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables insulin receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of mitotic spindle asymmetry IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in melanotic encapsulation of foreign target IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton polarization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of elongator holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
elongator complex protein 6
Names
CG9829-PA
CG9829-PB
Elp6-PA
Elp6-PB
lethal (3) 05137
poly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13361816..13366910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202286.1 → NP_001189215.1  elongator complex protein 6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189215.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NH01, Q9VFW4
    UniProtKB/TrEMBL
    Q6NP11
    Conserved Domains (1) summary
    pfam09807
    Location:26 → 236
    ELP6; Elongation complex protein 6

  2. NM_079619.4 → NP_524343.2  elongator complex protein 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524343.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NH01, Q9VFW4
    UniProtKB/TrEMBL
    Q6NP11
    Related
    FBpp0082240
    Conserved Domains (1) summary
    pfam09807
    Location:26 → 236
    ELP6; Elongation complex protein 6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NH01 Q9NH01
Q9VFW4 Q9VFW4

Gene LinkOut

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