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Lpt Lost PHDs of trr [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37795, updated on 4-Jan-2025

Summary

Official Symbol
Lptprovided by FlyBase
Official Full Name
Lost PHDs of trrprovided by FlyBase
Primary source
FLYBASE:FBgn0263667
Locus tag
Dmel_CG5591
See related
AllianceGenome:FB:FBgn0263667
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cara Mitad; cg5591; CG5591; cmi; Cmi; Dmel\CG5591; lpt; LPT
Summary
Enables several functions, including histone H3K4 methyltransferase activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Involved in imaginal disc-derived wing vein morphogenesis; positive regulation of ecdysone receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on ecdysis, chitin-based cuticle. Located in chromatin and polytene chromosome. Part of MLL3/4 complex. Is active in nucleus. Is expressed in several structures, including embryonic/larval midgut; ganglia; imaginal disc; spermatozoon; and wing cell. Used to study congenital heart disease. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Lpt in Genome Data Viewer
Location:
60A9-60A9; 2-105 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23898561..23903661)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19786084..19791184)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene DNA ligase 1 Neighboring gene Upf3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45926 Neighboring gene Nucleosome assembly protein 1

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of MLL3/4 complex  
part_of MLL3/4 complex PubMed 
located_in chromatin PubMed 
is_active_in nucleus PubMed 
located_in polytene chromosome PubMed 

General protein information

Preferred Names
lost PHDs of trr
Names
CG5591-PA
CG5591-PB
Lpt-PA
Lpt-PB
cara mitad
lost PHD finger of Trr
lost PHDs of Trr
NP_001286792.1
NP_611847.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23898561..23903661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138003.3 → NP_611847.2  lost PHDs of trr, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611847.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1H0
    Related
    FBpp0072043
    Conserved Domains (9) summary
    smart00398
    Location:1173 → 1231
    HMG; high mobility group
    COG5648
    Location:1101 → 1237
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd15509
    Location:205 → 250
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15510
    Location:252 → 298
    PHD2_KMT2C_like; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15512
    Location:530 → 578
    PHD4_KMT2C_like; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD domain 3 found in KMT2D
    cd15513
    Location:580 → 625
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15514
    Location:657 → 707
    PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
    cd15665
    Location:109 → 191
    ePHD1_KMT2C_like; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cl22851
    Location:337 → 392
    PHD_SF; PHD finger superfamily
  2. NM_001299863.1 → NP_001286792.1  lost PHDs of trr, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGG6
    Conserved Domains (8) summary
    smart00398
    Location:1169 → 1227
    HMG; high mobility group
    COG5648
    Location:1097 → 1233
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd15509
    Location:205 → 250
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15510
    Location:252 → 298
    PHD2_KMT2C_like; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15512
    Location:530 → 578
    PHD4_KMT2C_like; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD domain 3 found in KMT2D
    cd15513
    Location:580 → 625
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15514
    Location:657 → 707
    PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
    cl22851
    Location:109 → 191
    PHD_SF; PHD finger superfamily
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