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Pa1 PTIP associated 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32079, updated on 4-Jan-2025

Summary

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Official Symbol
Pa1provided by FlyBase
Official Full Name
PTIP associated 1provided by FlyBase
Primary source
FLYBASE:FBgn0287454
Locus tag
Dmel_CG11750
See related
AllianceGenome:FB:FBgn0287454
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-10B; anon-10Ba; BcDNA:RE09126; BcDNA:RH21749; CG11750; Dmel\CG11750; dPA1; PA1
Summary
Part of MLL3/4 complex. Is expressed in organism. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Orthologous to human PAGR1 (PAXIP1 associated glutamate rich protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Pa1 in Genome Data Viewer
Location:
10B5-10B5; 1-34 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11359236..11360929)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11253269..11254962)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene dishevelled Neighboring gene hopscotch Neighboring gene Tim8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. dishevelled is required during wingless signaling to establish both cell polarity and cell identity. Theisen H, et al. Development, 1994 Feb. PMID 8149913
  2. Dissecting the complexity of CNV pathogenicity: insights from Drosophila and zebrafish models. Yusuff T, et al. Curr Opin Genet Dev, 2021 Jun. PMID 33812298, Free PMC Article
  3. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Herz HM, et al. Genes Dev, 2012 Dec 1. PMID 23166019, Free PMC Article
  4. A dystroglycan-laminin-integrin axis coordinates cell shape remodeling in the developing Drosophila retina. Walther RF, et al. PLoS Biol, 2024 Sep. PMID 39226305, Free PMC Article
  5. The COMPASS family of H3K4 methylases in Drosophila. Mohan M, et al. Mol Cell Biol, 2011 Nov. PMID 21875999, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of MLL3/4 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
PTIP associated 1
Names
CG11750-PA
PTIP-associated 1
Pa1-PA
anon-10Ba

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11359236..11360929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132484.4 → NP_572712.1  PTIP associated 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572712.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYZ8
    Related
    FBpp0073312
    Conserved Domains (1) summary
    pfam15364
    Location:18 → 116
    PAXIP1_C; PAXIP1-associated-protein-1 C term PTIP binding protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VYZ8 Q9VYZ8

Gene LinkOut

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