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BuGZ Bub3 interacting GLEBS and Zinc finger domain protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35004, updated on 9-Dec-2024

Summary

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Official Symbol
BuGZprovided by FlyBase
Official Full Name
Bub3 interacting GLEBS and Zinc finger domain proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032600
Locus tag
Dmel_CG17912
See related
AllianceGenome:FB:FBgn0032600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD27810; buGZ; CG17912; Dmel\CG17912; Dm_2L:87597; lincRNA.S1359
Summary
Predicted to enable DNA binding activity. Involved in dendrite morphogenesis. Located in nucleus. Is expressed in organism. Orthologous to human ZNF207 (zinc finger protein 207). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See BuGZ in Genome Data Viewer
Location:
36A14-36A14; 2-52 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16743405..16753704)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16743405..16753704)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene NUBP iron-sulfur cluster assembly factor 1 Neighboring gene gluon Neighboring gene Chitin and LDLR binding deacetylase 3 Neighboring gene Like Sm 7 Neighboring gene yellow-b Neighboring gene pickpocket 17 Neighboring gene Myosin heavy chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing. Wan Y, et al. J Cell Biol, 2015 Apr 27. PMID 25918225, Free PMC Article
  2. Predictive regulatory models in Drosophila melanogaster by integrative inference of transcriptional networks. Marbach D, et al. Genome Res, 2012 Jul. PMID 22456606, Free PMC Article
  3. Phase separation of BuGZ regulates gut regeneration and aging through interaction with m(6)A regulators. Zhang Q, et al. Nat Commun, 2023 Oct 23. PMID 37872148, Free PMC Article
  4. Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes. Stanković D, et al. Life Sci Alliance, 2023 Feb. PMID 36446522, Free PMC Article
  5. Phase Separation in Asymmetric Cell Division. Wen W. Biochemistry, 2020 Jan 14. PMID 31617345

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phase separation of BuGZ regulates gut regeneration and aging through interaction with m[6]A regulators.
    Title: Phase separation of BuGZ regulates gut regeneration and aging through interaction with m(6)A regulators.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Bub3 interacting GLEBS and zinc finger domain protein
Names
BuGZ-PA
BuGZ-PB
BuGZ-PC
BuGZ-PD
BuGZ-PE
BuGZ-PF
BuGZ-PG
CG17912-PA
CG17912-PB
CG17912-PC
CG17912-PD
CG17912-PE
CG17912-PF
CG17912-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16743405..16753704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273584.2 → NP_001260513.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260513.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBC6
    Conserved Domains (2) summary
    TIGR01628
    Location:479 → 607
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001259118.3 → NP_001246047.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246047.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ09
    Conserved Domains (2) summary
    PRK14965
    Location:201 → 251
    PRK14965; DNA polymerase III subunits gamma and tau; Provisional
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001273583.2 → NP_001260512.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260512.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG25
    Conserved Domains (1) summary
    PRK14965
    Location:199 → 249
    PRK14965; DNA polymerase III subunits gamma and tau; Provisional

  4. NM_001259117.3 → NP_001246046.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246046.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ09
    Conserved Domains (2) summary
    PRK14965
    Location:201 → 251
    PRK14965; DNA polymerase III subunits gamma and tau; Provisional
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001103697.3 → NP_001097167.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097167.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ09
    Conserved Domains (2) summary
    PRK14965
    Location:201 → 251
    PRK14965; DNA polymerase III subunits gamma and tau; Provisional
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001299057.1 → NP_001285986.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285986.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JED0
    Conserved Domains (2) summary
    PRK14965
    Location:201 → 251
    PRK14965; DNA polymerase III subunits gamma and tau; Provisional
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_135964.3 → NP_609808.1  Bub3 interacting GLEBS and zinc finger domain protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609808.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961L0, Q9VJI6
    Related
    FBpp0080450
    Conserved Domains (2) summary
    PRK14965
    Location:201 → 251
    PRK14965; DNA polymerase III subunits gamma and tau; Provisional
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DZ09 A8DZ09
M9PBC6 M9PBC6
M9PG25 M9PG25
Q8SX73 Q8SX73
Q9VJI6 Q9VJI6
X2JED0 X2JED0

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