U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Su(var)205 Suppressor of variegation 205 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34119, updated on 9-Dec-2024

Summary

Official Symbol
Su(var)205provided by FlyBase
Official Full Name
Suppressor of variegation 205provided by FlyBase
Primary source
FLYBASE:FBgn0003607
Locus tag
Dmel_CG8409
See related
AllianceGenome:FB:FBgn0003607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CBX5; CG8409; dHP-1a; dHP1; dHP1a; Dmel\CG8409; DmHP-1; DmHP1; E(var)29; E(var)29A; FBgn0003607; HP-1; hp1; Hp1; HP1; HP1-VS; hp1a; Hp1a; HP1a; HP1A; HP1alpha; Su(var); Su(var)2-05; Su(var)2-5; Su(Var)2-5; Su(var)2-501; su(var)205; Su(Var)205; SU(VAR)205; Su(var)29A; Su(var)[205]; Su-var(2)5; Sur(var)205; Suvar(2)5; Suvar2-5; Su[var]205; Su[Var]205
Summary
Enables several functions, including Hsp70 protein binding activity; RNA polymerase II C-terminal domain binding activity; and nucleic acid binding activity. Involved in several processes, including positive regulation of FACT complex assembly; protein localization to euchromatin; and regulation of gene expression. Located in chromosome and nucleus. Colocalizes with polytene chromosome interband and polytene chromosome puff. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; ganglia; and gonad. Orthologous to human CBX1 (chromobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Su(var)205 in Genome Data Viewer
Location:
28F2-28F3; 2-30 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8209626..8211122, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8209626..8211122, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44120 Neighboring gene long non-coding RNA:CR44121 Neighboring gene uncharacterized protein Neighboring gene Single stranded-binding protein c31A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Hsp70 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II C-terminal domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone binding NAS
Non-traceable Author Statement
more info
PubMed 
enables mRNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables rDNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables satellite DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterochromatin formation HMP PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heterochromatin formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in pericentric heterochromatin formation HMP PubMed 
involved_in positive regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of FACT complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in siRNA-mediated heterochromatin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transposable element silencing by piRNA-mediated heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromocenter IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in heterochromatin NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in polytene chromosome chromocenter IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with polytene chromosome interband IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with polytene chromosome puff IDA
Inferred from Direct Assay
more info
PubMed 
located_in polytene chromosome puff TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
suppressor of variegation 205
Names
C1A9-nuclear-antigen
CG8409-PA
CG8409-PB
Su(var)2-5
Su(var)205-PA
Su(var)205-PB
heterochromatic protein
heterochromatic protein 1
heterochromatic protein 1a
heterochromatin factor 1
heterochromatin protein 1
heterochromatin protein 1A
heterochromatin protein-1
heterochromatin-binding protein
heterochromatin-protein-1
histone protein 1
suppressor of variegated 205

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8209626..8211122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057407.4NP_476755.1  suppressor of variegation 205, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476755.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0F1, B6UVR4, B6UVS1, B6UVS2, B6UVS3, B6UVT2, B6UVT6, B6UVT7, P05205, Q9VLR6
    Related
    FBpp0079251
    Conserved Domains (2) summary
    smart00300
    Location:141202
    ChSh; Chromo Shadow Domain
    cd00024
    Location:2472
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
  2. NM_164799.2NP_723361.1  suppressor of variegation 205, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723361.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0F1, B6UVR4, B6UVS1, B6UVS2, B6UVS3, B6UVT2, B6UVT6, B6UVT7, P05205, Q9VLR6
    Related
    FBpp0079252
    Conserved Domains (2) summary
    smart00300
    Location:141202
    ChSh; Chromo Shadow Domain
    cd00024
    Location:2472
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...