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Fer1HCH Ferritin 1 heavy chain homologue [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46415, updated on 27-Dec-2024

Summary

Official Symbol
Fer1HCHprovided by FlyBase
Official Full Name
Ferritin 1 heavy chain homologueprovided by FlyBase
Primary source
FLYBASE:FBgn0015222
Locus tag
Dmel_CG2216
See related
AllianceGenome:FB:FBgn0015222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1HCH; BEST:LD36673; CG2216; Dmel\CG2216; Fe1HCH; Fer-L; fer1; Fer1; FER1; Fer1H; Fer1HC; fer1hch; fer1HCH; FER1HCH; FerHCH; HCH; l(3)00451; l(3)j10B4; T21; T9
Summary
Enables ferrous iron binding activity. Involved in several processes, including detoxification of iron ion; iron ion import across plasma membrane; and sleep. Located in Golgi apparatus and fusome. Part of ferritin complex. Is expressed in several structures, including anterior-posterior subdivision of organism; brain; epithelial cell; nephrocyte; and somatic trunk mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Fer1HCH in Genome Data Viewer
Location:
99F2-99F2; 3-100 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30385573..30388178, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26211295..26213900, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene headcase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46114 Neighboring gene Ferritin 2 light chain homologue Neighboring gene long non-coding RNA:CR45570 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ferric iron binding  
enables ferric iron binding  
enables ferrous iron binding  
enables ferrous iron binding PubMed 
enables ferrous iron binding PubMed 
enables ferroxidase activity PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
is_active_in cytoplasm  
located_in extracellular region PubMed 
part_of ferritin complex PubMed 
located_in fusome PubMed 

General protein information

Preferred Names
ferritin 1 heavy chain homologue
Names
CG2216-PA
CG2216-PB
CG2216-PC
CG2216-PD
CG2216-PE
CG2216-PF
CG2216-PG
CG2216-PI
CG2216-PJ
Fer1HCH-PA
Fer1HCH-PB
Fer1HCH-PC
Fer1HCH-PD
Fer1HCH-PE
Fer1HCH-PF
Fer1HCH-PG
Fer1HCH-PI
Fer1HCH-PJ
Ferritin-Heavy
Ferritin-Light
Ferritin1
ferritin
ferritin 1 heavy chain
ferritin 1 heavy chain homolog
ferritin 1HCH
ferritin H
ferritin HCH
ferritin heavy chain
ferritin subunit 1
ferritin-1 heavy chain homolog
NP_001247366.1
NP_001247367.1
NP_001263104.1
NP_001287608.1
NP_524873.1
NP_733358.1
NP_733359.1
NP_733360.1
NP_733361.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30385573..30388178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080134.4NP_524873.1  ferritin 1 heavy chain homologue, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524873.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H1UUD2, Q7KMQ5, Q7KRU8, Q8I0T0
    UniProtKB/TrEMBL
    B9EQV2
    Related
    FBpp0084995
    Conserved Domains (2) summary
    cd01056
    Location:39203
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:42189
    Ferritin; Ferritin-like domain
  2. NM_170479.3NP_733358.1  ferritin 1 heavy chain homologue, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733358.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H1UUD2, Q7KMQ5, Q7KRU8, Q8I0T0
    UniProtKB/TrEMBL
    B9EQV2
    Related
    FBpp0084996
    Conserved Domains (2) summary
    cd01056
    Location:39203
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:42189
    Ferritin; Ferritin-like domain
  3. NM_170482.3NP_733361.1  ferritin 1 heavy chain homologue, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733361.1

    Status: REVIEWED

    Related
    FBpp0084999
    Conserved Domains (2) summary
    pfam00210
    Location:42102
    Ferritin; Ferritin-like domain
    cl00264
    Location:39102
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
  4. NM_001260438.2NP_001247367.1  ferritin 1 heavy chain homologue, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247367.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A405, B9EQV2
    Conserved Domains (2) summary
    cd01056
    Location:76240
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:79226
    Ferritin; Ferritin-like domain
  5. NM_170481.3NP_733360.1  ferritin 1 heavy chain homologue, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733360.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H1UUD2, Q7KMQ5, Q7KRU8, Q8I0T0
    UniProtKB/TrEMBL
    B9EQV2
    Related
    FBpp0084998
    Conserved Domains (2) summary
    cd01056
    Location:39203
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:42189
    Ferritin; Ferritin-like domain
  6. NM_170480.3NP_733359.1  ferritin 1 heavy chain homologue, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733359.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H1UUD2, Q7KMQ5, Q7KRU8, Q8I0T0
    UniProtKB/TrEMBL
    B9EQV2
    Related
    FBpp0084997
    Conserved Domains (2) summary
    cd01056
    Location:39203
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:42189
    Ferritin; Ferritin-like domain
  7. NM_001276175.2NP_001263104.1  ferritin 1 heavy chain homologue, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263104.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KI27, B9EQV2
    Conserved Domains (2) summary
    cd01056
    Location:79243
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:82229
    Ferritin; Ferritin-like domain
  8. NM_001300679.1NP_001287608.1  ferritin 1 heavy chain homologue, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287608.1

    Status: REVIEWED

    Conserved Domains (2) summary
    cd01056
    Location:3167
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:6153
    Ferritin; Ferritin-like domain
  9. NM_001260437.1NP_001247366.1  ferritin 1 heavy chain homologue, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247366.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A405, B9EQV2
    Conserved Domains (2) summary
    cd01056
    Location:76240
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:79226
    Ferritin; Ferritin-like domain
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