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4E-T eIF4E-Transporter [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43836, updated on 9-Dec-2024

Summary

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Official Symbol
4E-Tprovided by FlyBase
Official Full Name
eIF4E-Transporterprovided by FlyBase
Primary source
FLYBASE:FBgn0052016
Locus tag
Dmel_CG32016
See related
AllianceGenome:FB:FBgn0052016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11097; CG11232; CG32016; Dm4E-T; Dmel\CG32016
Summary
Enables eukaryotic initiation factor 4E binding activity. Involved in negative regulation of eukaryotic translation initiation factor 4F complex assembly. Located in P-body; cytosol; and nucleus. Is expressed in adult head. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See 4E-T in Genome Data Viewer
Location:
102F3-102F3; 4-0 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (951542..958392, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (972168..979018, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4G1 Neighboring gene metabotropic Glutamate Receptor Neighboring gene long non-coding RNA:CR45201 Neighboring gene antisense RNA:CR44030 Neighboring gene fussel

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing. Kamenska A, et al. Nucleic Acids Res, 2014 Mar. PMID 24335285, Free PMC Article
  2. Adult Movement Defects Associated with a CORL Mutation in Drosophila Display Behavioral Plasticity. Dimitriadou A, et al. G3 (Bethesda), 2020 May 4. PMID 32161085, Free PMC Article
  3. 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation. Igreja C, et al. Nat Commun, 2014 Sep 2. PMID 25179781, Free PMC Article
  4. Molecular architecture of 4E-BP translational inhibitors bound to eIF4E. Peter D, et al. Mol Cell, 2015 Mar 19. PMID 25702871
  5. CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila. Tran NL, et al. G3 (Bethesda), 2018 Aug 30. PMID 30006413, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c953198-953151 mobile_element_type = transposon:1360{}3507
  • Loc: c956342-955139 mobile_element_type = transposon:INE-1{}2903

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables eukaryotic initiation factor 4E binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of eukaryotic translation initiation factor 4F complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eIF4E-Transporter
Names
4E-T-PB
4E-T-PC
4E-T-PG
4E-T-PH
CG32016-PB
CG32016-PC
CG32016-PG
CG32016-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    951542..958392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166797.2 → NP_726619.2  eIF4E-Transporter, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726619.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    L0MLQ9, Q86BR2, Q8IH18, Q8IMA1
    UniProtKB/TrEMBL
    E8NH84
    Related
    FBpp0088293
    Conserved Domains (1) summary
    pfam10477
    Location:10 → 736
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  2. NM_166796.2 → NP_726618.3  eIF4E-Transporter, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726618.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    L0MLQ9, Q86BR2, Q8IH18, Q8IMA1
    UniProtKB/TrEMBL
    E8NH84
    Conserved Domains (1) summary
    pfam10477
    Location:10 → 736
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  3. NM_166798.2 → NP_726620.2  eIF4E-Transporter, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726620.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    L0MLQ9, Q86BR2, Q8IH18, Q8IMA1
    UniProtKB/TrEMBL
    E8NH84
    Related
    FBpp0088297
    Conserved Domains (1) summary
    pfam10477
    Location:10 → 736
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  4. NM_001272149.2 → NP_001259078.1  eIF4E-Transporter, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259078.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH84
    Conserved Domains (1) summary
    pfam10477
    Location:10 → 705
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IH18.1 Q8IH18

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