U.S. flag

An official website of the United States government

Men Malic enzyme [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47173, updated on 9-Dec-2024

Summary

Official Symbol
Menprovided by FlyBase
Official Full Name
Malic enzymeprovided by FlyBase
Primary source
FLYBASE:FBgn0002719
Locus tag
Dmel_CG10120
See related
AllianceGenome:FB:FBgn0002719
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.278; CG10120; Dmel\CG10120; MDH; Mdh-NADP; Me; ME; ME1; mem; men; MEN
Summary
Enables malate dehydrogenase (decarboxylating) (NADP+) activity. Involved in several processes, including determination of adult lifespan; malate metabolic process; and nicotinamide nucleotide metabolic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; brain; embryonic/larval hemocyte; germline cell; and somatic precursor cell. Orthologous to several human genes including ME1 (malic enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Men in Genome Data Viewer
Location:
87C6-87C7; 3-52 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12713103..12722442, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8538825..8548164, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ninjurin C Neighboring gene Putative Achaete Scute Target 1 Neighboring gene uncharacterized protein Neighboring gene DNA polymerase theta Neighboring gene long non-coding RNA:CR44231 Neighboring gene UDP-glycosyltransferase family 37 member A2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
located_in cytosol PubMed 
located_in cytosol PubMed 
is_active_in mitochondrion  
located_in mitochondrion  

General protein information

Preferred Names
malic enzyme
Names
CG10120-PA
CG10120-PB
CG10120-PC
Men-PA
Men-PB
Men-PC
NADP-dependent malate dehydrogenase
NADP-malic enzyme
malic enzyme (cytosolic)
NP_001262509.1
NP_524880.2
NP_731739.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12713103..12722442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080141.4 → NP_524880.2  malic enzyme, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524880.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NIW2, Q9VG31
    Related
    FBpp0082129
    Conserved Domains (3) summary
    cd05312
    Location:473 → 750
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:213 → 757
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:282 → 463
    malic; Malic enzyme, N-terminal domain
  2. NM_169479.2 → NP_731739.1  malic enzyme, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731739.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NIW1, Q9VG32
    Related
    FBpp0082130
    Conserved Domains (3) summary
    cd05312
    Location:469 → 746
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:209 → 753
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:278 → 459
    malic; Malic enzyme, N-terminal domain
  3. NM_001275580.1 → NP_001262509.1  malic enzyme, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262509.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H7BWU6, H7BWU8, Q2QBM1, Q9NIW0
    Conserved Domains (3) summary
    cd05312
    Location:288 → 565
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:28 → 572
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:97 → 278
    malic; Malic enzyme, N-terminal domain
External link. Please review our privacy policy.