Fim Fimbrin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fimprovided by FlyBase
Official Full Name: Fimbrinprovided by FlyBase
Primary source: FLYBASE:FBgn0024238
Locus tag: Dmel_CG8649
See related: AllianceGenome:FB:FBgn0024238
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8649; Dmel\CG8649; fim; FIM
Summary: Predicted to enable actin filament binding activity. Involved in actin crosslink formation; cortical actin cytoskeleton organization; and syncytial embryo cellularization. Located in apical cortex and cytosol. Colocalizes with contractile ring. Is expressed in adult brain; adult brain cell body rind; adult gnathal ganglion; adult head; and adult optic lobe. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76; congenital diaphragmatic hernia; and nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1); PLS1 (plastin 1); and PLS3 (plastin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 15F8-16A1; 1-57 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (17285704..17301929, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17179737..17195962, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in syncytial embryo cellularization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
located_in apical cortex	HDA more info	PubMed
colocalizes_with contractile ring	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: fimbrin

Names: CG8649-PA; CG8649-PC; CG8649-PD; Fim-PA; Fim-PC; Fim-PD; plastin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

17285704..17301929 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078661.4 → NP_523385.1 fimbrin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523385.1

Status: REVIEWED

UniProtKB/TrEMBL

D0IQI3, D3DMF1, O61604

Related

FBpp0074215

Conserved Domains (4) summary

smart00033
Location:395 → 496

CH; Calponin homology domain

COG5069
Location:6 → 618

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:18 → 79

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00307
Location:126 → 236

CH; Calponin homology (CH) domain
NM_167564.2 → NP_728073.1 fimbrin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728073.1

Status: REVIEWED

UniProtKB/TrEMBL

D0IQI3, D3DMF1, Q8IQZ8

Related

FBpp0074216

Conserved Domains (4) summary

smart00033
Location:492 → 594

CH; Calponin homology domain

pfam00307
Location:102 → 212

CH; Calponin homology (CH) domain

pfam13499
Location:1 → 59

EF-hand_7; EF-hand domain pair

cl08302
Location:1 → 55

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_167565.2 → NP_728074.1 fimbrin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728074.1

Status: REVIEWED

UniProtKB/TrEMBL

D0IQI3, D3DMF1, Q8IQZ7

Related

FBpp0074217

Conserved Domains (4) summary

smart00033
Location:396 → 497

CH; Calponin homology domain

pfam00307
Location:127 → 237

CH; Calponin homology (CH) domain

pfam13499
Location:27 → 84

EF-hand_7; EF-hand domain pair

cl08302
Location:27 → 80

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...