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Gonadal neoplasm

MedGen UID:
866873
•Concept ID:
C4021228
•
Neoplastic Process
Synonym: Gonadal neoplasia
 
HPO: HP:0010785

Definition

A tumor (abnormal growth of tissue) of a gonad. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGonadal neoplasm

Professional guidelines

PubMed

Workflow for Management of Gonadal Neoplasm in 2 Patients with Differences of Sex Development Enrolled in an Experimental Gonadal Tissue Cryopreservation Protocol.
Abdallah AS, Arva NC, Finlayson CA, Melin-Aldana H, Papadakis JL, Rowell EE, Weisman AG, Whitehead J, Yerkes EB, Yuodsnukis BT, Johnson EK, Laronda MM
Urology 2023 Aug;178:125-132. Epub 2023 May 24 doi: 10.1016/j.urology.2023.04.027. PMID: 37236371

Recent clinical studies

Etiology

Normal pelvic ultrasound or MRI does not rule out neoplasm in patients with gonadal dysgenesis and Y chromosome material.
Ebert KM, Hewitt GD, Indyk JA, McCracken KA, Nahata L, Jayanthi VR
J Pediatr Urol 2018 Apr;14(2):154.e1-154.e6. Epub 2017 Dec 23 doi: 10.1016/j.jpurol.2017.11.009. PMID: 29317190
Expression of SALL4 and SF-1 in gonadoblastoma: useful markers in the identification of the invasive germ cell component.
Bai S, Wei S, Ziober A, Yao Y, Bing Z
Int J Gynecol Pathol 2013 Jul;32(4):379-83. doi: 10.1097/PGP.0b013e31826a62ee. PMID: 23722510
Childhood gonadoblastoma and seminoma in a dysgenetic cryptorchid gonad.
Mandell J, Stevens PS, Fried FA
J Urol 1977 May;117(5):674-5. doi: 10.1016/s0022-5347(17)58583-3. PMID: 16143
Extragenital gonadal neoplasia and metastatic testicular tumor.
Wacksman J, Case G, Glenn JF
Urology 1975 Feb;5(2):221-3. doi: 10.1016/0090-4295(75)90014-x. PMID: 1114559

Diagnosis

Normal pelvic ultrasound or MRI does not rule out neoplasm in patients with gonadal dysgenesis and Y chromosome material.
Ebert KM, Hewitt GD, Indyk JA, McCracken KA, Nahata L, Jayanthi VR
J Pediatr Urol 2018 Apr;14(2):154.e1-154.e6. Epub 2017 Dec 23 doi: 10.1016/j.jpurol.2017.11.009. PMID: 29317190
Neurologic disorders associated with disease of the ovaries and testis.
Kattah JC, Kattah WC
Handb Clin Neurol 2014;120:787-98. doi: 10.1016/B978-0-7020-4087-0.00052-8. PMID: 24365352
Precocious puberty and statural growth.
Carel JC, Lahlou N, Roger M, Chaussain JL
Hum Reprod Update 2004 Mar-Apr;10(2):135-47. doi: 10.1093/humupd/dmh012. PMID: 15073143
A case of gonadal dysgenesis, breast development, Graves' disease, and low bone mass.
Tanwani LK, Chudgar D, Murphree SS, Eblen AC, Mokshagundam SP
Endocr Pract 2003 May-Jun;9(3):220-4. doi: 10.4158/EP.9.3.220. PMID: 12917064
Case of gonadoblastoma in a 9-year-old boy without physical abnormalities.
Hatano T, Yoshino Y, Kawashima Y, Shirai H, Iizuka N, Miyazawa Y, Sakata A, Onishi T
Int J Urol 1999 Mar;6(3):164-6. doi: 10.1046/j.1442-2042.1999.06331.x. PMID: 10226831

Therapy

A case of gonadal dysgenesis, breast development, Graves' disease, and low bone mass.
Tanwani LK, Chudgar D, Murphree SS, Eblen AC, Mokshagundam SP
Endocr Pract 2003 May-Jun;9(3):220-4. doi: 10.4158/EP.9.3.220. PMID: 12917064

Prognosis

Expression of SALL4 and SF-1 in gonadoblastoma: useful markers in the identification of the invasive germ cell component.
Bai S, Wei S, Ziober A, Yao Y, Bing Z
Int J Gynecol Pathol 2013 Jul;32(4):379-83. doi: 10.1097/PGP.0b013e31826a62ee. PMID: 23722510
Precocious puberty and statural growth.
Carel JC, Lahlou N, Roger M, Chaussain JL
Hum Reprod Update 2004 Mar-Apr;10(2):135-47. doi: 10.1093/humupd/dmh012. PMID: 15073143

Clinical prediction guides

Precocious puberty and statural growth.
Carel JC, Lahlou N, Roger M, Chaussain JL
Hum Reprod Update 2004 Mar-Apr;10(2):135-47. doi: 10.1093/humupd/dmh012. PMID: 15073143
A case of gonadal dysgenesis, breast development, Graves' disease, and low bone mass.
Tanwani LK, Chudgar D, Murphree SS, Eblen AC, Mokshagundam SP
Endocr Pract 2003 May-Jun;9(3):220-4. doi: 10.4158/EP.9.3.220. PMID: 12917064

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