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Trophoblastic tumor

MedGen UID:
21708
•Concept ID:
C0041182
•
Neoplastic Process
Synonyms: Neoplasm, Trophoblast; Neoplasm, Trophoblastic; Neoplasms, Trophoblast; Neoplasms, Trophoblastic; Trophoblast Neoplasm; Trophoblast Neoplasms; Trophoblast Tumor; Trophoblast Tumors; Trophoblastic Neoplasm; Trophoblastic Neoplasms; Trophoblastic Tumor; Trophoblastic Tumors; Tumor, Trophoblast; Tumor, Trophoblastic; Tumors, Trophoblast; Tumors, Trophoblastic
SNOMED CT: Trophoblastic neoplasm (115234004)
 
HPO: HP:0031502
Monarch Initiative: MONDO:0002872

Definition

A gestational or non-gestational neoplasm composed of neoplastic trophoblastic cells [NCIT:C3422]. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrophoblastic tumor

Professional guidelines

PubMed

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586

Recent clinical studies

Etiology

Gestational trophoblastic disease: an update.
Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Diagnosis

Gestational trophoblastic disease: an update.
Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Placental chorioangioma: literature review.
Fan M, Skupski DW
J Perinat Med 2014 May;42(3):273-9. doi: 10.1515/jpm-2013-0170. PMID: 24334427

Therapy

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Placental site trophoblastic tumors and epithelioid trophoblastic tumors: Biology, natural history, and treatment modalities.
Horowitz NS, Goldstein DP, Berkowitz RS
Gynecol Oncol 2017 Jan;144(1):208-214. Epub 2016 Oct 24 doi: 10.1016/j.ygyno.2016.10.024. PMID: 27789086
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069
Gestational trophoblastic disease.
Berkowitz RS, Goldstein DP
Cancer 1995 Nov 15;76(10 Suppl):2079-85. doi: 10.1002/1097-0142(19951115)76:10+<2079::aid-cncr2820761329>3.0.co;2-o. PMID: 8635004

Prognosis

Gestational trophoblastic disease: an update.
Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Placental chorioangioma: literature review.
Fan M, Skupski DW
J Perinat Med 2014 May;42(3):273-9. doi: 10.1515/jpm-2013-0170. PMID: 24334427
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Clinical prediction guides

Gestational trophoblastic disease: an update.
Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Gestational trophoblastic neoplasia: Novelties and challenges.
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586

Recent systematic reviews

Clinical features and management of trophoblastic epithelioid tumors: A systematic review.
Gorun F, Tomescu L, Motoc A, Citu C, Sas I, Serban DM, Forga M, Citu IM, Gorun OM
Medicine (Baltimore) 2022 Jul 29;101(30):e29934. doi: 10.1097/MD.0000000000029934. PMID: 35905248Free PMC Article
Fertility and pregnancy outcome in gestational trophoblastic disease.
Joneborg U, Coopmans L, van Trommel N, Seckl M, Lok CAR
Int J Gynecol Cancer 2021 Mar;31(3):399-411. doi: 10.1136/ijgc-2020-001784. PMID: 33649007
Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2019 Jun;153(3):684-693. Epub 2019 Apr 30 doi: 10.1016/j.ygyno.2019.03.011. PMID: 31047719
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article
Combination chemotherapy for high-risk gestational trophoblastic tumour.
Deng L, Yan X, Zhang J, Wu T
Cochrane Database Syst Rev 2009 Apr 15;(2):CD005196. doi: 10.1002/14651858.CD005196.pub3. PMID: 19370618

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