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Sertoli-Leydig cell tumor

MedGen UID:
61669
Concept ID:
C0206723
Neoplastic Process
Synonyms: Androblastoma; Androblastomas; Arrhenoblastoma; Arrhenoblastomas; Cell Tumor, Sertoli-Leydig; Cell Tumors, Sertoli-Leydig; Sertoli Leydig Cell Tumor; Sertoli Leydig Cell Tumors; Sertoli-Leydig Cell Tumor; Sertoli-Leydig Cell Tumors; Tumor, Sertoli-Leydig Cell; Tumors, Sertoli-Leydig Cell
 
Monarch Initiative: MONDO:0002479

Definition

A sex cord-gonadal stromal tumor consists of leydig cells; sertoli cells; and fibroblasts in varying proportions and degree of differentiation. Most such tumors produce androgens in the Leydig cells, formerly known as androblastoma or arrhenoblastoma. Androblastomas occur in the testis or the ovary causing precocious masculinization in the males, and defeminization, or virilization (virilism) in the females. In some cases, the Sertoli cells produce estrogens. [from MONDO]

Professional guidelines

PubMed

Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Nasioudis D, Orfanelli T, Frey MK, Chapman-Davis E, Caputo TA, Witkin SS, Holcomb K
J Gynecol Oncol 2019 Mar;30(2):e19. Epub 2018 Nov 12 doi: 10.3802/jgo.2019.30.e19. PMID: 30740951Free PMC Article

Recent clinical studies

Etiology

Muscat C, Calleja-Agius J
Discov Med 2024 Feb;36(181):234-247. doi: 10.24976/Discov.Med.202436181.22. PMID: 38409829
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Koo J, Garrington TP, Kerr K, Treece AL, Cost CR
Pediatr Blood Cancer 2020 Oct;67(10):e28621. Epub 2020 Jul 30 doi: 10.1002/pbc.28621. PMID: 32729194
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Lantzsch T, Stoerer S, Lawrenz K, Buchmann J, Strauss HG, Koelbl H
Arch Gynecol Obstet 2001 Jan;264(4):206-8. doi: 10.1007/s004040000114. PMID: 11205710

Diagnosis

Villegas Cruz C, Berlanga Narro S, Saltijeral SN, Roman Montalvo MA
Int J Gynecol Cancer 2024 Sep 2;34(9):1476-1478. doi: 10.1136/ijgc-2023-004321. PMID: 38088150
Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Pommert L, Bradley W
Curr Oncol Rep 2017 Jul;19(7):44. doi: 10.1007/s11912-017-0604-7. PMID: 28501984

Therapy

Wang G, Zhang R, Li C, Chen A
J Ovarian Res 2021 Nov 4;14(1):150. doi: 10.1186/s13048-021-00909-7. PMID: 34736487Free PMC Article
Gressel GM, Buza N, Pal L
Eur J Gynaecol Oncol 2017;38(2):214-220. PMID: 29953783
Rosenberg P, Carinelli S, Peiretti M, Zanagnolo V, Maggioni A
Arch Gynecol Obstet 2012 Mar;285(3):845-8. Epub 2011 Aug 17 doi: 10.1007/s00404-011-2017-4. PMID: 21847587
Chao HT, Wang PH, Lin HD
Int J Gynaecol Obstet 1999 Aug;66(2):189-90. doi: 10.1016/s0020-7292(99)00071-5. PMID: 10468350
Tomlinson MW, Treadwell MC, Deppe G
Eur J Gynaecol Oncol 1997;18(1):44-6. PMID: 9061323

Prognosis

Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Koo J, Garrington TP, Kerr K, Treece AL, Cost CR
Pediatr Blood Cancer 2020 Oct;67(10):e28621. Epub 2020 Jul 30 doi: 10.1002/pbc.28621. PMID: 32729194

Clinical prediction guides

Muscat C, Calleja-Agius J
Discov Med 2024 Feb;36(181):234-247. doi: 10.24976/Discov.Med.202436181.22. PMID: 38409829
Wang G, Zhang R, Li C, Chen A
J Ovarian Res 2021 Nov 4;14(1):150. doi: 10.1186/s13048-021-00909-7. PMID: 34736487Free PMC Article
Chen J, Liu Y, Zhang Y, Wang Y, Chen X, Wang Z
Sci Prog 2021 Apr-Jun;104(2):368504211009668. doi: 10.1177/00368504211009668. PMID: 33848213Free PMC Article
Guillerman RP, Foulkes WD, Priest JR
Pediatr Radiol 2019 Oct;49(11):1488-1505. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04429-x. PMID: 31620849
Schultz KA, Harris AK, Schneider DT, Young RH, Brown J, Gershenson DM, Dehner LP, Hill DA, Messinger YH, Frazier AL
J Oncol Pract 2016 Oct;12(10):940-946. doi: 10.1200/JOP.2016.016261. PMID: 27858560Free PMC Article

Recent systematic reviews

Nef J, Huber DE
Eur J Obstet Gynecol Reprod Biol 2021 Aug;263:261-274. Epub 2021 Jun 28 doi: 10.1016/j.ejogrb.2021.06.036. PMID: 34245994
Cai S, Zhao W, Nie X, Abbas A, Fu L, Bihi S, Feng G, Liu T, Lv Y, Ma X, Peng X
J Pediatr Hematol Oncol 2017 Jul;39(5):355-361. doi: 10.1097/MPH.0000000000000715. PMID: 27906793
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718

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