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| Status |
Public on Mar 01, 2007 |
| Title |
Gene expression signatures that predict radiation exposure (mouse) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression analysis of peripheral blood leukocytes (PB MNCs) to develop expression profiles that accurately reflect prior radiation exposure.
Keywords: Comparative, exposure dosage, C57BI6 Murine Irradiation Studies
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| Overall design |
We have made use of gene expression analysis of peripheral blood mononuclear cells (PB MNCs) to develop expression profiles that accurately reflect prior radiation exposure. Importantly, we demonstrate that expression profiles can be developed that not only predict radiation exposure in mice but also distinguish the level of radiation exposure, ranging from 50 cGy to 1000 cGy. Likewise, a molecular signature of radiation response developed solely from irradiated human patient samples can predict and distinguish irradiated human PB samples from non-irradiated samples with an accuracy of 90%, sensitivity of 85% and specificity of 94%. We further demonstrate that a radiation profile developed in the mouse can correctly distinguish PB samples from irradiated and non-irradiated human patients with an accuracy of 77%, sensitivity of 82% and specificity of 75%. Taken together, these data demonstrate that molecular profiles can be generated which are highly predictive of different levels of radiation exposure in mice and humans.
Mouse Dataset only
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| Contributor(s) |
Dressman HK, Muramoto GG, Chao NJ, Meadows S, Marshall D, Ginsburg GS, Nevins JR, Chute JP |
| Citation(s) |
17407386 |
| |
| Submission date |
Jan 25, 2007 |
| Last update date |
Jan 18, 2013 |
| Contact name |
Holly Kloos Dressman |
| E-mail(s) |
[email protected]
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| Organization name |
Duke University Medical Center
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| Department |
Institute for Genome Sciences and Policy
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| Street address |
101 Science Drive
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| City |
Durham |
| State/province |
NC |
| ZIP/Postal code |
27708 |
| Country |
USA |
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| Platforms (1) |
| GPL4783 |
Operon Mouse V3.0.1 printed oligonucleotide array |
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| Samples (28)
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| This SubSeries is part of SuperSeries: |
| GSE6874 |
Gene expression signatures that predict radiation exposure |
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| Relations |
| BioProject |
PRJNA104109 |
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